Baptiste Lacoste
@blacoste.bsky.social
Senior Scientist, Professor & Program Director @ OHRI & uOttawa 🇨🇦. Fascinated by vascular & metabolic causes of neurodevelopmental disorders, SciArt and the night sky 🔬 🎨 🔭 Follow for 🧪 news and more! Look for #cerebrovascular
#cerebrovascular #atlas #human
Spatial atlas of the human brain vasculature reveals specialized cell ensembles
An integrative cell and spatial atlas defines the organizing logic of the adult human cerebrovasculature, providing a framework for studying how vascular cell states support brain function and shape n...
cell.com
I am delighted to welcome Dr. Aida Oryza Lopez-Ortiz in our lab ! Aida now joins our efforts to understand how astrocytes regulate cerebrovascular remodeling and repair. And to do so, she just received a prestigious Canada Impact+ Post-doctoral Training Award, what a great way to start !
🚨We have a new star in Ottawa! Consider joining Erika Wang’s lab if you are passionate about bioengineering, therapeutics and nanomedicine! 👇👇 #newrecruit #ECR
🚨 Now available on Nature Careers ! #Recruitment #Ottawa
Tier 2 Canada Research Chair in Vascular Links to Neurodevelopment - Ottawa, Ontario (CA) job with University of Ottawa, Ontario CANADA | 12861923
uOttawa, in partnership with the OHRI, invites applications for a Tier 2 CRC in Vascular Links to Neurodevelopment and their impact on brain health.
nature.com
Excited to share that one of the very first research projects initiated in our ABCD lab, "Astrocytic Ankyrin-2 Enables Memory Persistence in the Mouse Hippocampus," has now been published in Nature Communications (DOI: 10.1038/s41467-026-75009-5). www.drkohlab.com/post/our-art...
Astrocytic Ankyrin-2 Enables Memory Persistence in the Mouse Hippocampus
Why do some memories last for weeks, months, or even years, while others quickly fade away? Astrocytes may hold the key.
drkohlab.com
New paper by @craigedbrown.bsky.social ! #stroke #cerebrovascular
Knockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow and blood-brain barrier disruption - Cell Death & Disease
Cell Death & Disease - Knockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow and blood-brain barrier disruption
nature.com
🚨 We are recruiting at the Ottawa Hospital Research Institute, in the Regenerative Medicine Program ! If your are passionate about basic science, and dream to develop your own research program, please apply! #Ottawa #Canada #Recruitment #Scientist #Research Full description at the link below:
Tier 2 Canada Research Chair in Vascular Links to Neurodevelopment
Follow us on LinkedIn Posting Reason: New Position Job Type: Contingent Worker Anticipated Duration in Months (for contracts and temporary assignments): Job Family: Academic Leadership and Faculty # o...
uottawa.wd3.myworkdayjobs.com
A really elegant study by @alexdubrac.bsky.social & team, published at @natureportfolio.nature.com ! #cerebrovascular
Mapping neuro-vascular unit communications reveals distinct angiogenic programs across developing mouse brain regions - Nature Communications
Brain blood vessels interact with neural cells to shape brain development, yet how these communications differ across regions remains unclear. Here, the authors show that region-specific neurovascular...
nature.com
Very happy to share our latest work out in PNAS this week, led by Amy Xiang. We show that capillary thin-strand pericytes express TMEM16A calcium-activated chloride channels, which set the operating point for capillary control of cerebral blood flow in vivo. www.pnas.org/doi/10.1073/...
New paper by @caglaeroglu.bsky.social ! #astrocytes #development
Neuroligin-2 is ubiquitinated by Nedd4l to control developmental astrocyte morphogenesis
Sakers et al. report that astrocytic NLs are functionally diverse proteins with unique intracellular protein–protein interactions. They show that Nedd4l bi
doi.org
Amazing paper by Andrew Yang's lab using a new, a non-invasive genetic system to trace neuron-derived protein clearance from the brain to cerebrospinal fluid and border tissues 🤩 #cerebrovascular www.sciencedirect.com/science/arti...
Our cerebrovascular symposium @canacn.bsky.social in Montreal was a blast with full room! Thanks Aurélie, Grant, Ravi and Alex for your fantastic talks! May the vessels be with you 💪 #symposium #CanadianNeuroscience #cerebrovascular
The absolute dream paper for any #cerebrovascular developmental biologist !! Congrats to @nicolasrenier.bsky.social, @alexdubrac.bsky.social and their teams !
The spatiotemporal dynamics of postnatal vascularization in the mouse brain
Whole-brain tissue clearing and spatial transcriptomics were applied to map postnatal vascular development in the mouse brain, identifying three coordinated phases that link vascular growth to neurona...
cell.com
New study clarifies the role of Angiopoietin 2 in the brain vasculature #Cerebrovascular 👇
JCI insight@insight.jci.org · 4mo agoAngiopoietin 2 promotes vascular permeability in peripheral organs, but its role in brain is unclear. doi.org/10.1172/jci.... Li et al. show ANGPT2 loss in mice leads to region-specific brain malformations and blood-brain barrier leakage.
Look at this beautiful preprint ! by Neil Dani & team #ChoroidPlexus #BrainBarrier www.biorxiv.org/content/10.6...
biorxiv.org
New insights into brain imaging by @annadevor.bsky.social just dropped 🧠✨ This study shows that neuromodulators, especially norepinephrine, actively reshape how neural activity translates into blood flow signals across the cortex. A powerful step toward more accurate brain mapping! #cerebrovascular
The neurovascular impulse response function differentially reflects intrinsic neuromodulation across cortical regions - Nature Neuroscience
A new optical imaging study demonstrates that norepinephrine and the state of arousal influence hemodynamic correlations across cerebral cortex, calling for a conceptual shift in interpreting function...
nature.com
New results show that, in addition to neural changes, sleep involves nonneural processes such as vasomotor-driven hydrodynamic waves 🤩 #Cerebrovascular #sleep
Sleep alters neurovascular and hydrodynamic coupling in the human brain | PNAS
Sleep is essential for maintaining brain tissue homeostasis, which is facilitated by enhanced cerebrospinal fluid (CSF) solute transport. Infraslow...
pnas.org
🚨Our new paper in Circ Research on the cover + 📖 editorial by Dr. Jackson🔗https://tinyurl.com/2d6hxa83 👏 Danielle Jeffrey tinyurl.com/bdduwe43 collaboration with @osamaharraz.bsky.social Lab ♀️ Female mice show lower hippocampal tone 🌸 Estrogen-dependent⚡️ SK channels dominate 💡 Ludeman Family Center
Wrapping up my visit to UVA, had a great time and learned about a lot of exciting stuff! Thanks @eyolab.bsky.social for hosting me!
Professional advice: when celebrating your 10th year lab anniversary🍻, bring your trainees to an axe throwing club, so they can release all the anger accumulated. Let them imaging your face is on the wall 😂
Cool neurovascular paper in #zebrafish #cerebrovascular #development
NMDA receptors coordinate brain vascular development via neuron-to-endothelial tip cell crosstalk in zebrafish - Nature Communications
Neurovascular interaction is critical for normal brain vascular development. Here, the authors show that neuronal NMDARs regulate brain vascular development via VEGF-induced global Ca2+ activities of ...
nature.com
New findings suggesting that PROX1 compromises BBB integrity by negatively regulating BBB-associated Wnt signaling. #BBB #BloodBrainBarrier #cerebrovascular
JCI Insight - Endothelial PROX1 induces blood-brain barrier disruption in the central nervous system
insight.jci.org
🎉 New Publication in @pnas.org Excited to share our lab’s latest research article: PIP₂ Corrects an Endothelial Piezo1 Channelopathy pnas.org/doi/abs/10.1... (Open Access)
New preprint from the lab! For those who love astrocytes 🤩. We welcome feedback! #preprint #openaccess #astrocytes #autism
Metabolic, epigenetic and transcriptomic alterations in postnatal 16p11.2 deficient murine astrocytes
Autism Spectrum Disorders (ASD) are associated with metabolic dysregulation. While astrocytes are integral to cerebral metabolism, their molecular and functional changes in ASD are poorly known. Using...
biorxiv.org
A beautiful paper from my friend @naguibmechawar.bsky.social's team ! www.nature.com/articles/s41... #cerebrovascular
Pervasive neurovascular dysfunction in the ventromedial prefrontal cortex of female depressed suicides with a history of childhood abuse - Molecular Psychiatry
Molecular Psychiatry - Pervasive neurovascular dysfunction in the ventromedial prefrontal cortex of female depressed suicides with a history of childhood abuse
nature.com
PDGFRα is required for postnatal cerebral perivascular fibroblast development. Congrats @siegenthalerlab.bsky.social ! #cerebrovascular #fibroblasts #development
PDGFRα is required for postnatal cerebral perivascular fibroblast development
Perivascular fibroblasts (PVFs) are a cell type associated with large diameter blood vessels in the brain and spinal cord parenchyma and leptomeninges…
sciencedirect.com
Excited to share the latest from our lab (final version, open access): Brain Capillary Ion Channels: Physiology and Channelopathies Physiology | @apspublications.bsky.social journals.physiology.org/doi/full/10.... @uvmlarnermed.bsky.social
