I finally got around to making a lab poster! 🌱 It highlights what @theustunlab.bsky.social is all about: uncovering how #microbes hijack plant #proteostasis & how we can reprogram proteostasis to mitigate stress-induced proteotoxicity. Excited to see where this research takes us! ♻️🔬 #theustunlab

Congratulations to the team at @theustunlab.bsky.social on your two new publications! 🎉 We're proud that 25 Agrisera antibodies were used in these studies. Thank you for choosing Agrisera! Read the articles here: 🔗 www.science.org/doi/10.1126/... 🔗 www.cell.com/molecular-ce...

Bacteria use P-body condensates to attenuate host translation during infection

Bacterial pathogens hijack P-body condensates to suppress host translation and dampen plant immunity.

science.org

Indeed - CDC48 & ERAD are important to maintain cellular homeostasis - see our contribution to this field: www.cell.com/molecular-ce... Beyond degradation, those components are also essential for nuclear delivery of proteasome transcriptional activators - to control the trade-off growth/stress

Proteotoxic stress response is governed by ER-associated sorting of proteasome transcriptional activators

Langin et al. find that ER-associated sorting (ERAS) directs NAC53/78 turnover and activation to couple proteasome induction with repression of photosynthesis genes, linking proteostasis to energy met...

cell.com

Ryo Yokoyama@yokoyama-ryo.bsky.social · last mo.

Comparative analysis of Cdc48-dependent proteolysis at the ER, mitochondria and chloroplasts www.nature.com/articles/s41... @natcomms.nature.com

After 2 months of hard work by @shanshuo.bsky.social with huge support by @manuelgonzalezfuen.bsky.social,help by @nico-slz.bsky.social & a bit myself (😅) we did "finalise" our paper & are finally "𝘶𝘯𝘥𝘦𝘳 𝘳𝘦𝘷𝘪𝘦𝘸" 🤞 Here is the last version of our paper: www.biorxiv.org/content/10.6... #openscience

Autophagy acts as a spatial organizer of cell-type-specific plant immunity

Effective plant immunity requires precise spatial coordination of immune responses across cell-types to restrict pathogens while preventing tissue damage, yet the intracellular pathways that organize ...

biorxiv.org

Şuayb Üstün@suaybuestuen.bsky.social · 2mo ago

2) 🔬We show that EDS1 is degraded by autophagy during Pst infection - most likely in the mesophyll 🌱🦠 Our model: autophagy recycles EDS1 during infection. Without this turnover, EDS1 accumulates (explaining elevated SA in atg5?!) but EDS1-dependent HR fails. 🔄💥 Ready to submit 🤞

I do not want our preprints being „ranked“ in the future by AI. We preprint to foster #openscience sharing it with our community and to make the research of early careers more visibile to help them for future positions etc. We do not need more competition bias and pressure.

QED Science@qedscience.bsky.social · last mo.

🎉 Meet The 1%. Out of 57,455 bioRxiv life science preprints, QED Science selected 574 exceptional manuscripts through blind evaluation. The 1%: the-one-percent.qedscience.com Good science deserves to be seen. @biorxivpreprint.bsky.social @openrxiv.bsky.social @richardsever.bsky.social

How Plants Rebalance Their Energy under Stress When under stress, plants cut back on energy production to focus on breaking down damaged proteins. buff.ly/gOmDH6e via @ruhr-uni-bochum.de #PlantScience

🌱 Enjoyed teaching plant immunity (PTI,effectors,NLRs) today & bringing this topic closer to our students. The best part were the students'❓: 🔬 What is the stoichiometry of effector–NLR complexes? ⏳ What is their half-life? ⚡ How do NLR Ca²⁺ channels "execute" death? #PlantScience #PlantImmunity

Interested to join us to study plant proteostasis? We study host translation controlled by condensates 🧬, cell-type specific proteostasis ♻️, proteotoxic stress in the context of biotic and abiotic stress 🦠🔥🧂 👉 Build your own project in @theustunlab.bsky.social ⏳ Sept 9 #MSCA #Postdoc

European Commission@ec.europa.eu · 4mo ago

Big opportunities for researchers 🌍 We are investing nearly €400 million to help researchers share their work and collaborate with the best scientific teams across the EU. The 2026 Marie Skłodowska-Curie Actions Postdoctoral Fellowships are now open. More: link.europa.eu/PNxpxw

Don't forget to register for one of the biggest #PlantScience conferences 🌱 of the year! Our lab has submitted 9 abstracts (incl. our MSc students)- the entire @theustunlab.bsky.social will be there. Come meet us & learn how we study #proteostasis ♻️ & plant–microbe interactions. See you there! 🌿

German Society for Plant Sciences (DBG)@plantsciencedbg.bsky.social · 2mo ago

⏳ Only 2 days left for poster abstract submissions considered for a poster talk at #BT2026, the International Conference of our @plantsciencedbg.bsky.social (DBG) 🚨 Deadline is 11 June 2026, 23:59 (CEST)

🌱Update on our preprint "𝘈𝘶𝘵𝘰𝘱𝘩𝘢𝘨𝘺 𝘢𝘴 𝘢 𝘴𝘱𝘢𝘵𝘪𝘢𝘭 𝘰𝘳𝘨𝘢𝘯𝘪𝘻𝘦𝘳 𝘰𝘧 𝘱𝘭𝘢𝘯𝘵 𝘪𝘮𝘮𝘶𝘯𝘪𝘵𝘺" www.biorxiv.org/content/10.6... 1) 🧬 mesophyll autophagy rescues ETI; guard cell autophagy does not ⚡ PTI competence likely requires autophagy across tissues—not just in mesophyll or guard cells.

Şuayb Üstün@suaybuestuen.bsky.social · 4mo ago

Preprint alert 🚨 (1/10) 🧵 𝘈𝘶𝘵𝘰𝘱𝘩𝘢𝘨𝘺 𝘪𝘴 𝘢 𝘱𝘢𝘳𝘢𝘥𝘰𝘹 𝘪𝘯 𝘱𝘭𝘢𝘯𝘵 𝘪𝘮𝘮𝘶𝘯𝘪𝘵𝘺: It can promote resistance, susceptibility, or restrict cell death 🤯 So what is its actual role? We show it acts as a spatial organizer of immunity across cell types 🌱🦠 #proteostasis www.biorxiv.org/content/10.6...

This was so much fun - talking about our recent data on spatial organization of plant immunity! Thank you Carmen and Javi for the invitation - @ihsmumacsic.bsky.social is a really amazing place to do science in beautiful Málaga 🤩

Victoria Sánchez-Vera@gritocosmico.bsky.social · 3mo ago

Great talk today @ihsmumacsic.bsky.social from @theustunlab.bsky.social about proteostasis and autophagy during Pseudomonas infection. Single cell autophagy response is definitely something crucial to deepen our understanding of this recycling process.

Great talk today @ihsmumacsic.bsky.social from @theustunlab.bsky.social about proteostasis and autophagy during Pseudomonas infection. Single cell autophagy response is definitely something crucial to deepen our understanding of this recycling process.

See my new post on our homepage ✍️ The journey to our newest publication on how plants cope with proteotoxic stress ♻️ www.cell.com/molecular-ce... From Doubt to Discovery: A 15-Year Journey into Proteostasis, Pathogens, and Persistence

From Doubt to Discovery: A 15-Year Journey into Proteostasis, Pathogens, and Persistence

More than 15 years ago, during my PhD, we stumbled upon something unexpected. In a yeast two-hybrid screen, bacterial effector proteins from Xanthomonas and Pseudomonas interacted with a subunit of…

theustunlab.com

📋 Join us on Friday 8th for a fascinating talk by Suayib Ustun from the Ruhr University Bochum (Germany) as part of the #IHSMLaMayoraSeminars series Don't miss it! 🕑 9:30 AM 📍 IHSM La Mayora Auditorium

Next stop Spain/Málaga 😍 Excited to talk about cell-type specificity,spatial immunity, heterogeneity & then in one of my favorite countries 🤩 I will mainly present our work on how „Autophagy acts as spatial organizer of cell-type specific 🌱 immunity“ www.biorxiv.org/content/10.6...

IHSM La Mayora UMA-CSIC@ihsmumacsic.bsky.social · 3mo ago

📋 Join us on Friday 8th for a fascinating talk by Suayib Ustun from the Ruhr University Bochum (Germany) as part of the #IHSMLaMayoraSeminars series Don't miss it! 🕑 9:30 AM 📍 IHSM La Mayora Auditorium

Preprint alert 🚨 (1/10) 🧵 𝘈𝘶𝘵𝘰𝘱𝘩𝘢𝘨𝘺 𝘪𝘴 𝘢 𝘱𝘢𝘳𝘢𝘥𝘰𝘹 𝘪𝘯 𝘱𝘭𝘢𝘯𝘵 𝘪𝘮𝘮𝘶𝘯𝘪𝘵𝘺: It can promote resistance, susceptibility, or restrict cell death 🤯 So what is its actual role? We show it acts as a spatial organizer of immunity across cell types 🌱🦠 #proteostasis www.biorxiv.org/content/10.6...

Here you can find the press release by @ruhr-uni-bochum.de of on latest paper: „Proteotoxic stress response is governed by ER-associated sorting of proteasome transcriptional activators“ published in @cp-molcell.bsky.social www.cell.com/molecular-ce... #proteostasis

How Plants Rebalance Their Energy under Stress

When under stress, plants cut back on energy production to focus on breaking down damaged proteins.

news.rub.de

Pflanzen können unter Stress ihre Energiegewinnung drosseln und sich dafür auf die Reparatur beschädigter Proteine konzentrieren. Mit diesem Wissen könnte man sie robuster gegen Umwelteinflüsse machen.

Wie Pflanzen ihre Energie unter Stress neu ausbalancieren

Unter Stressbedingungen fahren Pflanzen die Energiegewinnung zurück, um die Priorität zunächst auf den Abbau beschädigter Proteine zu setzen.

news.rub.de

Happy to be here in beautiful Strasbourg and to present tomorrow our research @ibmp-cnrs.bsky.social on how pathogens target proteostasis, in particular host translation - see also our newest publication on it here: www.science.org/doi/10.1126/... #proteostasis #plantscience

Thrilled to introduce our next act 🎭 in @cp-molcell.bsky.social sciencedirect.com/science/arti... led by @glangin.bsky.social We uncover how proteotoxic stress is integrated across compartments, controlling proteasome activation ⚖️ vs photosynthesis repression 🌱 🧵(1/6) #proteostasis

Congratulations @glangin.bsky.social & @suaybuestuen.bsky.social lab!!! You guys are on 🔥 🔥 🔥

Şuayb Üstün@suaybuestuen.bsky.social · 3mo ago

Thrilled to introduce our next act 🎭 in @cp-molcell.bsky.social sciencedirect.com/science/arti... led by @glangin.bsky.social We uncover how proteotoxic stress is integrated across compartments, controlling proteasome activation ⚖️ vs photosynthesis repression 🌱 🧵(1/6) #proteostasis

Online Now: Proteotoxic stress response is governed by ER-associated sorting of proteasome transcriptional activators Online now:

Proteotoxic stress response is governed by ER-associated sorting of proteasome transcriptional activators

Langin et al. find that ER-associated sorting (ERAS) directs NAC53/78 turnover and activation to couple proteasome induction with repression of photosynthesis genes, linking proteostasis to energy metabolism during stress.

dlvr.it

Thrilled to see my main PhD project finally online @MolCell !! 🥳🌱🧬 If you want to know how the plant proteasome activators are sorted in a proteasome-dependent manner and how they coordinate transcriptional response during proteotoxic stress, please have a read ! 🤓 www.cell.com/molecular-ce...

Proteotoxic stress response is governed by ER-associated sorting of proteasome transcriptional activators

Langin et al. find that ER-associated sorting (ERAS) directs NAC53/78 turnover and activation to couple proteasome induction with repression of photosynthesis genes, linking proteostasis to energy met...

cell.com

Looking forward to hearing more about this nice story next week at @ibmp-cnrs.bsky.social!

Şuayb Üstün@suaybuestuen.bsky.social · 4mo ago

🚨 Paper out now in #ScienceAdvances @science.org 🌱🦠 Pathogens don’t just target protein degradation—they also hijack host translation. "Bacteria use P-body condensates to attenuate host translation during infection" ⚖️♻️ led by @manuelgonzalezfuen.bsky.social www.science.org/doi/10.1126/...

New post on our homepage ✍️🌱 The story behind our P-body paper in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴 🦠 www.science.org/doi/10.1126/... A ~9-year journey—from “just try it” to uncovering how pathogens hijack translation • hidden gems 💎: 𝘗-𝘣𝘰𝘥𝘺 𝘢𝘶𝘵𝘰𝘱𝘩𝘢𝘨𝘺 𝘳𝘦𝘤𝘦𝘱𝘵𝘰𝘳, 𝘛𝘖𝘙 𝘪𝘯𝘢𝘤𝘵𝘪𝘷𝘢𝘵𝘪𝘰𝘯 𝘣𝘺 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 & 𝘌𝘙 𝘴𝘵𝘳𝘦𝘴𝘴 ✨

Our journey to publish our P-body paper

Everything started maybe 9 years ago, during my postdoc in Sweden. My colleague and friend Anders Hafrén, now also a group leader working on P-bodies and stress granules during viral infection, had…

theustunlab.com

Here’s the press release by @ruhr-uni-bochum.de for our newest publication 🧬✨ “Bacteria use P-body condensates to attenuate host translation during infection” How pathogens rewire host translation via condensates 🔄🌱 #plantscience #proteostasis www.science.org/doi/10.1126/...

How Bacteria Circumvent Plants’ Immune System

Bacteria deactivate the protein synthesis of host cells to hamper immune reactions. This insight could aid in the development of more resistant plants.

news.rub.de

Bakterien tricksen das Immunsystem von Pflanzen aus, um sie zu infizieren. Dieses Wissen könnte helfen, resistentere Pflanzen zu entwickeln.

Wie Bakterien das Immunsystem von Pflanzen überlisten

Bakterien schalten die Proteinsynthese von Wirtszellen aus, um Immunreaktionen abzuschwächen. Diese Erkenntnis könnte helfen, resistentere Pflanzen zu entwickeln.

news.rub.de

🚨 Paper out now in #ScienceAdvances @science.org 🌱🦠 Pathogens don’t just target protein degradation—they also hijack host translation. "Bacteria use P-body condensates to attenuate host translation during infection" ⚖️♻️ led by @manuelgonzalezfuen.bsky.social www.science.org/doi/10.1126/...

Come to Bochum 🌱 — we’d love to host all #plantscience peeps! From biotic interactions 🦠 to #proteostasis ♻️ and development 🌿, there’s something for everyone. Looking forward to inspiring science & great conversations ✨ More info here: botanik-tagung.de

Plantae.org@plantaeofficial.bsky.social · 4mo ago

📅New #PlantSciEvents Event Added: International Conference of the German Society for Plant Sciences 👉 buff.ly/iNTF27m #PlantScience

Autophagy acts as a spatial organizer of cell-type-specific plant immunity theustunlab.com/2026/04/12/a... www.biorxiv.org/content/10.6... #proteostasis #plantscience #plantimmunity #theustunlab

Autophagy acts as a spatial organizer of cell-type-specific plant immunity

To prevent frequent outbreak of diseases, plants have acquired a complex and multi-layered immune system. Cell surface immune receptors recognize conserved pathogen-associated molecular patterns (P…

theustunlab.com