The ARLA1A-NAC089 module coordinates ER phagy with the unfolded protein response to maintain cellular homeostasis in plants

Yang et al. reveal that the ARLA1A-NAC089 module couples ER phagy with the UPR in plants. This dual regulatory axis fine-tunes cell survival versus death under stress, providing a mechanistic framewor...

cell.com

Atg1 phosphorylates Atg2 to gate phospholipid flow through a continuous conduit for autophagosome biogenesis

Autophagosome biogenesis requires delivery of millions of phospholipids. In budding yeast, Atg2 and Atg18 couple the ER to the isolation membrane for lipid transport, yet the mechanism is poorly under...

biorxiv.org

Diversity and evolution of chromatin regulatory states across eukaryotes - Nature Genetics

This study introduces iChIP2, a low-input chromatin immunoprecipitation followed by sequencing method that profiles histone post-translational modifications (hPTMs) simultaneously across diverse eukar...

nature.com

Spatiotemporal control of Atg2 association with the ER during autophagosome formation | PNAS

Autophagy degrades various intracellular components by sequestering them within membrane vesicles called autophagosomes and delivering them to lyso...

pnas.org

Scientific Director (f/m/x)

OeAW - Discovering the futureThe Gregor Mendel Institute of Molecular Plant Biology (GMI), part of the Austrian Academy of Sciences (OeAW), is seeking to appoint a visionary Scientific Director to lea

oeawnr.onlyfy.jobs

Functional diversification of UBP6 in plant immunity through N‑degron pathway regulation

Deubiquitylases are key proteolytic regulators of ubiquitin-dependent cellular processes, catalyzing the removal or remodelling of ubiquitin modifications on substrate proteins, including those target...

biorxiv.org

A role for tubulin in cellular quality control and proteostasis

Microtubules, stiff rods built up from tubulin dimers, form a cytoskeletal network whose structure, behaviour, and function have been extensively investigated, mainly from a mechanical perspective. He...

biorxiv.org

The mechanical properties of Arabidopsis thaliana roots adapt dynamically during development and to stress

Brillouin microscopy reveals in vivo dynamics of mechanical properties during plant development and response to stress.

science.org

Going viral – Plant selective autophagy swiping left and right on viral infections

Selective autophagy has emerged as a central interface in plant–virus interactions, acting at once as an antiviral defense, a proviral vulnerability, …

sciencedirect.com

Atg23 prevents aberrant fusion of Atg9 vesicles during delivery to autophagosome formation sites - The EMBO Journal

Autophagosome biogenesis depends on the accurate delivery of membrane lipids to the pre-autophagosomal structure. Golgi/endosome-derived Atg9 vesicles provide the membrane seed for this process, but h...

link.springer.com

Mitochondrial-derived vesicles drive budding-type fission of damaged lysosomes - Nature Cell Biology

Luo et al. describe a budding type of lysosome fission linked to delivery of MFF from mitochondrial-derived vesicles to lysosomes. MFF recruits DRP1 for membrane scission. This axis restores lysosome ...

nature.com

The ERAD ubiquitin ligase Doa10 negatively regulates Atg32-mediated mitophagy

Degradation of defective or superfluous mitochondria via mitophagy, a specialized form of selective autophagy, is important for maintaining mitochondrial quality and quantity. In yeast, the pro-mitoph...

biorxiv.org

Bacteria use P-body condensates to attenuate host translation during infection

Bacterial pathogens hijack P-body condensates to suppress host translation and dampen plant immunity.

science.org

CASM regulates p62/KEAP1/NRF2 antioxidant responses to lysosome damage

Effective lysosome function is essential for health, and declines with ageing and disease. Upon lysosome damage, cells mount a complex stress response to restore homeostasis. Membrane ATG8ylation play...

biorxiv.org

Autophagy as a regulatory node integrating the carbon/nitrogen ratio with the auxin-driven chloronema-to-caulonema transition in Physcomitrium patens

Plants, as sessile living systems, have the capacity to respond to both internal and external signals by modulating their growth and developmental programs. Autophagy is a recycling process which is k...

biorxiv.org

TRIM21 induces selective autophagy of viruses and bacteria

Rhinesmith et al. describe an intracellular antimicrobial mechanism called “antibody-directed xenophagy” (ADX). In ADX, the E3 ubiquitin ligase TRIM21 prevents infection by intercepting antibody-coated viruses/bacteria in the cytosol and orchestrating their destruction via selective autophagy. The authors hypothesize that ADX may be co-opted for targeted protein degradation.

dlvr.it

FERONIA orchestrates plasma membrane nanoclusters for plant thermotolerance

Climate warming poses increasing thermal challenges to plants, yet how plasma membrane biophysics contributes to heat adaptation remains poorly understood. In this work, we showed that the malectin-li...

science.org

Pesticide-free agriculture: Is a third way possible besides organic and conventional agriculture? | Plant Disease

Pesticides are widely used in agriculture to protect crops from animal pests, diseases, and weeds, helping to maintain yields under diverse production conditions. However, their widespread and repeate...

apsjournals.apsnet.org

French physicist and media star loses doctorate after plagiarism investigation

University punishes Étienne Klein after investigation shows he plagiarized part of his Ph.D. thesis

scim.ag