Clement Vinauger

@thevinaugerlab.bsky.social

Associate Professor, Biochemistry Dpt & School of Neuroscience at Virginia Tech. Disease vector insects, medical entomology, neuroethology, mosquitoes.

Check out this new preprint from the lab: www.biorxiv.org/content/10.6... Lan Lou, @juliendevilliers.bsky.social, @karthikeyanc.bsky.social, @lahonderelab.bsky.social, the Tu Lab, and @joshuabenoit.bsky.social show that mosquito olfactory rhythms are synced with daily rhythms in how we smell.

Temporal synchrony between human odor rhythms and mosquito olfactory preference shapes host attraction

For anthropophilic mosquitoes such as Aedes aegypti, aligning host-seeking with human availability enhances foraging efficiency and reproductive success. Although time of day modulates mosquito activity and olfactory sensitivity, it remains unknown whether human hosts display rhythmic changes in odor cues and whether mosquitoes adjust their sensory responses accordingly. Here, we combine chemical, behavioral, genetic, and transcriptomic approaches to reveal that both mosquitoes and their human hosts in this interaction are temporally synchronized. Gas chromatography-mass spectrometry showed systematic daily shifts in human body odor composition between morning and evening. Correspondingly, mosquitoes prefer host odors that match their own active phase, a time-specific preference abolished in timeless mutants and under constant darkness. Silencing the timeless gene further induced an aversion for the host scent under light-dark conditions. Transcriptomic analysis of mosquito heads and antennae uncovered rhythmic expression of sensory and neuromodulatory genes, driven by both circadian and light-dark cycles and which peaks during mosquitoes' active periods, with rhythmic co-expression networks collapsing in timeless knockouts. Together, these results show that mosquito attraction to humans is temporally tuned by the interplay of host odor rhythms and mosquito sensory rhythms, revealing a previously unrecognized form of interspecific temporal synchronization in vector-host interactions. ### Competing Interest Statement The authors have declared no competing interest. National Institutes of Health, R01AI155785, R21AI166633, R01AI148551 National Institute of Food and Agriculture, VA-160212

biorxiv.org

If you are attending #EntSoc25 in Portland, Check out the work of Sydney Luff and @mdessart.bsky.social who are representing the lab at the meeting!

Martin Dessart@mdessart.bsky.social · 9mo ago

As part of the @thevinaugerlab.bsky.social Lab, I'll present my work on mosquitoes facing threats on Wed at 10:30am in MUVE symposium! Sydney Luff from our lab will also present her work on mosquito activity in wild populations. Go check out her poster on Mon at 1:30pm! #EntSoc25

The Agrawal lab is moving! This January we will be setting up shop at #UBC in Vancouver, in the department of #Zoology! We are actively recruiting at all levels, especially masters and PhD students. These position are #funded! Please send anyone interested my way!

Agrawal lab logo. A fly in the UBC colors, with dots framing its body.

🚨New preprint from the lab! Work led by our talented former postdoc @karthikeyanc.bsky.social where we show that incomplete larval control can make things worse by producing bigger and meaner adult mosquitoes that are more efficient vectors of Zika. See thread below www.biorxiv.org/content/10.1...

biorxiv.org

Karthikeyan Chandrasegaran@karthikeyanc.bsky.social · last yr.

@bluethread.bsky.social 1/15 Larval competition... profoundly alters adult body size, survival, reproductive output, host-seeking behavior, olfactory neurophysiology, and vector competence." In our new study, we trace how early-life environment reshapes adult disease risk in Aedes aegypti. #Preprint

Giving Day is almost there! Initiatives around Global Climate Change need more support than ever! Please consider donating to the @globalchangevt.bsky.social tomorrow!

Global Change Center at Virginia Tech@globalchangevt.bsky.social · last yr.

#VTGivingDay starts THIS Wednesday at noon! Join us Feb 19-20 to support the GCC and drive real-world solutions through innovative environmental research, impactful education, and community outreach. 🌍💡 Share and stay tuned for how you can help!

attn #SICB2025! a tech from my lab, Wayne Kuo, will be presenting a poster on fly landing! Find out how flies use mechanosensory info to decide when and how to land. Now soliciting names for our assay...we're currently calling it the Hokie Pokie P4-67 on Tues Jan 7, part of "Flying and vision"

The lab is super excited to welcome @mdessart.bsky.social as a new postdoc fellow! Stay tuned for the work to come on mosquito sensory ecology and chronobiology. Welcome, Martin!

Martin Dessart@mdessart.bsky.social · 2y ago

I'm thrilled to announce that I've recently started a postdoc position at Virginia Tech, joining the @thevinaugerlab.bsky.social lab to continue diving into the fascinating world of mosquito behaviour! I'm enthusiastic to collaborate with a talented team and do exciting research on 🦟 🦟 🦟

Great to see our former postdoc —now Assist. Prof. @ UC Riverside — Karthikeyan Chandrasegaran at the ESA meeting in Phoenix, AZ! His lab is recruiting at the graduate level. Reach out if you’re interested!

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Check out our newest paper on mosquito sugar feeding! This study led by PhD student Forde Upshur shows that mosquitoes, including invasive species such as Aedes aegypti and Ae. albopictus, feed on a very wide range of wild & ornamental plants, and can obtain carbs throughout the season rdcu.be/dtwJO

Mosquito feeding on a wild flower (Virginia, USA).