New work with Ben Medoff's lab, online now! ADAMTS14 regulates YAP-driven fibroblast activation in IPF. We define an ADAMTS14–collagen V–focal adhesion pathway that contributes to $fibrosis, highlighting ADAMTS14 as a potential therapeutic target. doi.org/10.1093/ajrc...

ADAMTS14 is a Novel Modulator of Fibroblast Mechanoactivation in Pulmonary Fibrosis

AbstractRationale. Yes-associated protein (YAP)-mediated fibroblast mechanoactivation is an important driver of fibrosis in idiopathic pulmonary fibrosis (

doi.org

Check out this @NatureMedicine Comment about the importance of studying heritage diets and the World Diet Initiative’s efforts to translate dietary diversity into health benefits for the global community: www.nature.com/articles/s41...

Studying vanishing dietary diversity before it is lost: the World Diet Initiative - Nature Medicine

Heritage diets are disappearing as food systems homogenize; their effects on immunity, metabolism and host–microbiome biology remain poorly understood. The World Diet Initiative offers a framework to ...

nature.com

Join us and @genelayinstitute.bsky.social on July 31st for the Annual Symposium! This year's speakers include Marco Colonna, Shimon Sakaguchi, Stefani Spranger, and Gabriel Victora. Register using the QR code in the flyer! #inflammation #immunity #disease #genelayinstitute

It's that time of year again--we are saying goodbye to more of our youngest and brightest lab members as they transition to the next steps of their careers, either in grad school or in other institutions. This week, we are saying goodbye to Anna, Regan, and Tanvi.

New website launch for the World Diet Initiative—an international effort to map global dietary patterns and their impacts on human health. The site is now accepting heritage diet submissions to build the open-access World Diet Atlas. www.worlddietinitiative.org

Congratulations to postdoc Sacha Lebon on publishing his graduate work! Using single-cell profiling, his study reveals how intestinal epithelial stem cells sense and respond to bacterial invasion. www.nature.com/articles/s41...

Early-life interventions & airway microbiome Nasal microbial gene atlas in infants w/cystic fibrosis. Hypertonic saline inhalation reshapes microbiome, selects salt-tolerant H. influenzae & ⬆️transporters linked to antibiotic tolerance @thexavierlab.bsky.social www.cell.com/cell-host-mi...

An infant nasal microbial gene atlas uncovers intervention-driven microbiome shifts and salt-resistant pathogen expansion

Steinberg et al. generated an infant nasal microbial gene atlas using samples from infants with and without cystic fibrosis. Frequent hypertonic saline inhalation reshapes airway microbiome function, ...

cell.com

What the nose knows of cystic fibrosis microbes and hypertonic saline Bouzek Previews work by @thexavierlab.bsky.social presenting microbial gene atlas of nasopharyngeal swabs in infants w/cystic fibrosis & healthy controls & IDing impacts of clinical interventions www.cell.com/cell-host-mi...

What the nose knows of cystic fibrosis microbes and hypertonic saline

In this issue of Cell Host & Microbe, Steinberg et al. present a microbial gene atlas of nasopharyngeal swabs in infants with cystic fibrosis and healthy controls using shotgun metagenomic sequencing....

cell.com

Excited to share this new preprint from a large collaborative effort using #exome + #genome sequencing, moving beyond GWAS to implicate 68 genes in #IBD through rare protein-coding variation. bit.ly/43h72GA @broadinstitute.org @mgbresearch.bsky.social

Exome sequencing directly implicates 68 genes in inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder of the gastrointestinal tract whose genetic basis is only partly resolved because most risk variants identified by genome-wide as...

bit.ly

Excited to share our new @cp-immunity.bsky.social review, discussing how advances in functional genomics and chemical biology are enabling the translation of IBD genetics into mechanistic understanding and new therapeutic hypotheses. www.cell.com/immunity/ful... #IBD #inflammatoryboweldisease

Mechanisms of inflammatory bowel diseases: Insights from human genetics and chemical biology

Advancements in human genetics have catalyzed rapid discovery in immunology. Graham and Xavier review how functional genomics and chemical biology have joined forces to uncover mechanisms of mucosal i...

cell.com

Out now in @cp-cellhostmicrobe.bsky.social! In collaboration with Swiss clinicians, we built the largest nasal microbial gene atlas in infants w/ and w/o cystic fibrosis to date (cont.)

Our latest work, with Mika Kivimaki's lab, now online @alzdemjournals.bsky.social: we used single-cell and GWAS data to uncover genes in peripheral blood immune cells associated with Alzheimer’s disease. doi.org/10.1002/alz.... @broadinstitute @MGHMolBio @MGBResearchNews #Alzheimers

Population and single‐cell analyses reveal immune cell‐specific expression profiles associated with Alzheimer's disease risk

INTRODUCTION Dysregulation of the peripheral immune system may increase Alzheimer's disease (AD) risk, but the underlying cell type-specific mechanisms remain unclear. METHODS We conducted Mendeli...

doi.org

New work with @CarolineUhler, now online in @natcomms.nature.com! We developed TRIM, a multimodal framework integrating T cell RNA and TCR profiling to predict T cell responses to cancer treatment. www.nature.com/articles/s41... @broadinstitute @MGHMolBio @MGBResearchNews

New study, in collaboration with Kenya Honda, out now in @nature.com. We show how a low protein diet drives a microbiota-dependent induction of thermogenic brown adipocytes via FXR & FGF21 pathways. www.nature.com/articles/s41...

Microbiota-mediated induction of beige adipocytes in response to dietary cues - Nature

In mice, a low-protein diet leads to a gut-microbiota-driven remodelling of adipose tissue towards brown fat, showing that gut microorganisms have a role in detecting and responding to a lack of prote...

nature.com

Check out this great write-up of a recent study between the @broadinstitute.org , University of Helsinki, and other institutions which has found more than 400 genetic markers that are linked to autoimmune hypothyroidism (AIHT). (1/4) www.broadinstitute.org/news/study-r...

Study reveals genetic balancing act between autoimmunity and cancer risk

Researchers pinpoint genetic factors linked to both higher risk of a common autoimmune disorder and lower cancer risk

broadinstitute.org

Excited to share our new study defining the multicellular ecosystem of atopic dermatitis. Integrating >700k single cells from healthy and inflamed skin, we uncover disease-specific immune circuits linked to disrupted keratinocyte differentiation. www.nature.com/articles/s41...

7/ Thanks to Elena Wu and senior authors Damian Plichta, @carriesokol.bsky.social, @thexavierlab.bsky.social, Sergio Bacallado. A cross-disciplinary effort across @broadinstitute.org, @massgeneralbrigham.bsky.social, @cam.ac.uk, @cuanschutz.bsky.social, @gatescambridge.bsky.social

(1/2) New paper out now in Cell Systems @cellpress.bsky.social describing development of a deep learning framework to predict allergenic microbial proteases! www.sciencedirect.com/science/arti... @broadinstitute.org @mgbresearch.bsky.social

Identifying microbial protease allergens through protein language model-guided homology

Emerging research links the gut, skin, and oral microbiomes to allergies, with serine proteases (SPs) identified as potential allergens. This study le…

sciencedirect.com

We’re looking forward to the upcoming 2nd International Conference on Individualized Infection Medicine in Hannover, 19–21 March 2026. Registration is still open! www.ciim-hannover.de/aktuelles/sy...

Nice to see our recent CARD9 work covered in @natrevdrugdiscov.nature.com, with a focus on our two-step screening approach for identifying binders of challenging targets. www.nature.com/articles/d41...

Two-step screen for CARD9 inhibitors

Discover the world’s best science and medicine | Nature.com

nature.com

Excited to share our latest study in Cell Genomics, combining single-nucleus RNA-seq, spatial transcriptomics, and histology to dissect the molecular determinants of lung fibrosis! www.cell.com/cell-genomic... #fibrosis #lung #ILD

Spatial transcriptomics reveals altered communities and drivers of aberrant epithelia and pro-fibrotic fibroblasts in interstitial lung diseases

Using single-nucleus RNA sequencing and spatial transcriptomics, Jaiswal et al. identify disease-associated cell communities that include aberrant transitional alveolar epithelium and pro-fibrotic fib...

cell.com

(🧵1/7) New work, now online in @CellCellPress! Using a phased, binder-first strategy, we identified a ligandable pocket on CARD9 and discovered a small-molecule inhibitor of CARD9 inflammatory signaling. www.sciencedirect.com/science/arti...

Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity

Human genetic association studies highlight key genes involved in disease pathology, yet targets identified by these analyses often fall outside the t…

sciencedirect.com

Fun collaboration with @thexavierlab.bsky.social and Ribbeck groups to figure out how this human lectin plays multiple roles in controlling the #microbiome: stabilizing the mucus barrier and reducing bacteria that breach it. news.mit.edu/2026/protein... #glycotime

A protein found in the GI tract can neutralize many bacteria

MIT researchers found that a protein called intelectin-2 has broad spectrum antimicrobial activity against bacteria found in the GI tract. Additionally, intelectin-2 can crosslink molecules that make ...

news.mit.edu

Amazing work–with potential therapeutic implications–by the @laurakiessling.bsky.social group reveals dual actions of interlectin-2 in stabilizing mucosal barriers and targeting bacteria that escape a compromised barrier www.nature.com/articles/s41...

Amazing work–with potential therapeutic implications–by the @laurakiessling.bsky.social group reveals dual actions of interlectin-2 in stabilizing mucosal barriers and targeting bacteria that escape a compromised barrier www.nature.com/articles/s41...

Intelectin-2 is a broad-spectrum antimicrobial lectin - Nature Communications

Intelectin-2 defends mucosal interfaces by crosslinking mucus and blocking microbial growth. This study reveals that mouse and human intelectin-2 recognizes galactose-rich glycans to bind and target d...

nature.com

Very excited to share our latest work in @Nature integrating single-cell & spatial transcriptomics with bidirectional CRISPR screens to unravel an immune–stromal cell circuit dependent on the transcription factor GLIS3 that regulates intestinal fibrosis during chronic inflammation. Congrats, Vlad!

Broad Institute@broadinstitute.org · 7mo ago

Newly uncovered pathway behind tissue scarring, or fibrosis, in inflammatory bowel disease suggests new treatment strategies for the dangerous condition.

New in @NatureComms — collaborative work with the Knip & Orešič labs uncovers microbially conjugated bile acids in early life linked to immune development and type 1 diabetes risk. pubmed.ncbi.nlm.nih.gov/41339624/ @broadinstitute.org @mgbresearch.bsky.social

Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity - PubMed

Emerging studies reveal that gut microbes can conjugate diverse amino acids to bile acids, known as microbially conjugated bile acids. However, their regulation and health effects remain unclear. Here, we analyzed early-life microbially conjugated bile acid patterns and their link to islet autoimmun …

pubmed.ncbi.nlm.nih.gov

Register now for the International Human Microbiome Consortium (#IHMC) 2026, June 3–5 in Seoul, Korea! Join this global gathering of researchers for an exciting program highlighting the latest discoveries in human #microbiome science: www.ihmc2026seoul.com/html/

IHMC 2026 SEOUL

IHMC 2026 SEOUL 사이트입니다.

ihmc2026seoul.com

Excited to share our new FinnGen single-nucleus multiome preprint! 🧬 We profiled ~10M PBMCs (snRNA-seq + snATAC-seq) from 1,108 Finnish donors to map how genetic variants drive complex disease through chromatin and gene regulation 🧵👇 🔗 Link: www.medrxiv.org/content/10.1...

Registration now open for the International Congress of Mucosal Immunology (ICMI) 2026, Jul 13–17 in Montreal, Canada. www.socmucimm.org/meetings-eve... Looking forward to being part of this lineup of talks highlighting research at the interface of the immune system and mucosal surfaces!

ICMI 2026

ICMI provides an ideal opportunity to showcase your organization’s products and services and have direct interface with mucosal immunologists from around the globe.

socmucimm.org

Kumar Thurimella & co-authors addressed the challenge of functionally annotating uncharacterized microbial enzymes with CAZyLingua, a deep learning model for classifying CAZymes from metagenomics. (1/2)