SMAD4 MH2 Mutations Disrupt CREBBP/EP300 Recruitment and TGF-β-Induced Transcription in Colorectal Cancer https://www.biorxiv.org/content/10.64898/2026.06.30.735541v1
Timothy En Haw Chan
@timothykoala.bsky.social
👨🔬 PhD IMPRS-IEM @UniFreiburg @mpi_ie focus on #epigenetics #cancer #TXPN #synbio. social network = online archive for interesting discoveries. dreamome.com
You never forget your first love. www.nature.com/articles/s41...
A tunable CTD grammar governs the spatial programming of the transcription cycle - Nature Communications
The C-terminal domain (CTD) of RNA polymerase II acts as a regulatory platform during the transcription cycle. Here, the authors use a simple tail CTD and reveal how repeating sequence patterns and ch...
nature.com
Run Chromatin, Run!
Genes & Development@genesdev.bsky.social · 2w agoON THE COVER: MLL4 on the treadmill of chromatin, supporting the stamina of TGF-β signaling. Artwork by Maria De-Castro. Learn more in this study by Chan et al. and Marc Timmers: ➡️ https://genesdev.cshlp.org/content/40/13-14/1012.abstract Timothy En Haw Chan Universität Freiburg @dkfz.bsky.social
RESEARCH PAPER: MLL4/KMT2D histone methyltransferase and JUNB cooperate in a feed-forward loop to support AP-1-dependent TGF-β signaling By Chan et al. and Marc Timmers ➡️ https://genesdev.cshlp.org/content/40/13-14/1012.abstract Timothy En Haw Chan Universität Freiburg #epigenetics #transcription
Thanks Genes & Development for using our work of TGF-β induced MLL4 recruitment as cover page 📓🧬. We reveal a novel role for the histone methyltransferase MLL4 (KMT2D) in transcriptional responses to TGF-β. We show that MLL4 is recruited to TGF-β target genes including JUNB while TGF-β treatment.
Genes & Development@genesdev.bsky.social · last mo.🚨 NEW ISSUE ALERT!!! 🚨 New Research articles online now at Genes & Development! Also in this issue, an Outlook on ATR in translesion synthesis, and a Review about the mechanisms controlling stem cell state exit. Click here to learn more: ➡️ https://genesdev.cshlp.org/content/40/13-14.toc
Correction of the molecular phenotype of X-linked Dystonia-Parkinsonism reveals a non-canonical function of BRD4. www.nature.com/articles/s41...
Correction of the molecular phenotype of X-linked Dystonia-Parkinsonism reveals a non-canonical function of BRD4 - Nature Communications
X‑linked dystonia‑parkinsonism involves disrupted transcription and mRNA processing. Here, the authors show that altering 3′ mRNA processing rescues the disease molecular signature, linking XDP pathol...
nature.com
Sharing a free online symposium which dives into 20+ top life sciences PhD programs across 7 European countries. All full funded positions. www.doctoralinsights.at @docinsightssymp.bsky.social
Doctoralinsights
Thinking about a PhD in life sciences? Learn what to expect, get advice from experts, and find the right program in Austria or across Europe.
doctoralinsights.at
A paper in Nature presents molecular clocks that can provide accurate estimates of both molecular age and lifespan across multiple mammalian species and tissue types. This framework may aid the development of targeted interventions to improve longevity. go.nature.com/4tYXdYM 🧬🧪
🚥🧬How do cells sense external signals and turn them into lasting responses? We discovered that TGF-β induces the recruitment of MLL4 (KMT2D), which works together with the transcription factor JUNB to form a positive feed-forward loop.
Genes & Development@genesdev.bsky.social · 2mo ago🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: MLL4/KMT2D histone methyltransferase and JUNB cooperate in a feed-forward loop to support AP-1-dependent TGF-β signaling By Chan et al. and and Marc Timmers ➡️ https://ow.ly/K48V50Z4Uhe #epigenetics #transcription #histone #TGFβ
How does a cell learn? In our new perspective in @nature.com we propose a model where the properties of the AP-1 family of transcription factors – stress-induced feedback, regulatory combinatorics and cellular memory – encode a mechanism for cellular learning. www.nature.com/articles/s41...
New research from MSK, led by Dr. Scott Lowe, Dr. Dana Pe'er, & colleagues, shows how pancreatic cells can shift from a benign state to cancer — revealing a key “switch” in this process. The study, published in @cellpress.bsky.social, identifies a critical window for early detection and prevention.
From Benign Growth to Pancreatic Cancer: New Study Shows How the Switch Gets Flipped | Memorial Sloan Kettering Cancer Center
An MSK study reveals new details about how pancreatic cells carrying oncogenic mutations transition from benign to malignant — shining new light on the ecosystems that supports emerging tumors.
mskcc.org
Epigenome encoded inflammation memory and primes stem cells for cancer via AP-1 activity. www.nature.com/articles/s41...
Epigenetic memory of colitis promotes tumour growth - Nature
Colonic stem cells retain a memory of inflammation following disease resolution and there is a mechanistic link between chronic inflammation and malignancy, suggesting potential strategies to mitigate...
nature.com
AP-1 mediates cellular adaptation and memory formation. www.nature.com/articles/s41...
AP-1 mediates cellular adaptation and memory formation - Nature Communications
Cellular responses to stimuli can involve learned behaviors through memory formation. Here, the authors show that cancer cells encode gene expression into cellular memories during therapy resistance v...
nature.com
How to make a heterochromatin by major satellite repeats transcripts? www.nature.com/articles/s41...
Transcriptional competence defines the heterochromatin nucleating potential of isolated MSR units - Nature Communications
Multiple copies of intact MSR nucleate de novo heterochromatin and reveal that the establishment of mouse pericentric heterochromatin is associated with bidirectional repeat RNA, Integrator complex en...
nature.com
A disease model resource reveals core principles of tissue-specific cancer evolution. www.nature.com/articles/s41...
A disease model resource reveals core principles of tissue-specific cancer evolution - Nature
The Mouse Cancer Cell line Atlas (MCCA) provides major advances towards a mechanistic understanding of cancer genomes.
nature.com
Organism-wide cellular dynamics and epigenomic remodeling in mammalian aging www.science.org/doi/10.1126/...
Organism-wide cellular dynamics and epigenomic remodeling in mammalian aging
To investigate organism-wide cellular alterations and epigenomic dynamics during aging, we constructed a single-cell chromatin accessibility atlas spanning 21 mouse tissues across three age groups and...
science.org
A nice piece to read: The epigenetic circle: feedback loops in the maintenance of cellular memory. link.springer.com/article/10.1...
The epigenetic circle: feedback loops in the maintenance of cellular memory - Epigenetics & Chromatin
The memory of gene expression states, active or repressive, is a fundamental biological concept as it controls cell fate in development, immunity and abiotic stress responses. Such memory is maintaine...
link.springer.com
A discovery in mice reveals why fasting enhances a type of breast cancer treatment go.nature.com/4oUCGCk
How fasting boosts breast cancer therapy
A discovery in mice reveals why fasting enhances a type of breast cancer treatment — a hormone-signalling pathway and gene-expression changes have key roles.
go.nature.com
Molecular determinants for recognition of serotonylated chromatin academic.oup.com/nar/article/...
Molecular determinants for recognition of serotonylated chromatin
Abstract. Post-translational modifications of histone tails constitute a key epigenetic mechanism controlling chromatin environment and gene transcription.
academic.oup.com
Contrasting roles of MLL3 and MLL4 histone methyltransferases in breast cancer www.nature.com/articles/s41...
Contrasting roles of KMT2C and KMT2D in breast cancer - Scientific Reports
Scientific Reports - Contrasting roles of KMT2C and KMT2D in breast cancer
nature.com
Requirements for establishment and epigenetic stability of mammalian heterochromatin. www.cell.com/molecular-ce...
Requirements for establishment and epigenetic stability of mammalian heterochromatin
Tatarakis et al. study how H3K9me3 heterochromatin is formed and inherited in mammalian cells. Using a synthetic heterochromatin assembly system and genetic screens, they uncover requirements for init...
cell.com
Online Now: Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription
Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription
Taghbalout et al. apply collections of advanced multi-omics analyses to substantiate ecDNA’s mobile enhancer model in diverse types of cancer models, reveal the MED1-ecDNA condensates and establish their causal links to the modulation of oncogenic expression and cell proliferation. This study offers a chromatin-based mechanism of ecDNA function in cancer.
dlvr.it
Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength
Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength
Wang et al. uncover that aged muscle stem cells have blunted PGE2-EP4 signaling that is critical for their regenerative function. Treatment with exogenous PGE2 reverses age-related defects in muscle stem cells and imparts an epigenetic response that enhances their capacity for repair after injury and transplantation.
dlvr.it
With the help of a technique called Massively Parallel Ribosome Profiling, researchers in Science have identified more than 4000 open reading frames—stretches of genetic material that can encode proteins—across 679 human-associated viral genomes. scim.ag/43RoAdF
Pan-viral ORFs discovery using massively parallel ribosome profiling
Defining viral proteomes is crucial to understanding viral life cycles and immune recognition but the landscape of translated regions remains unknown for most viruses. We have developed massively para...
scim.ag
Research about host-microbiome co-evolution on fungal infection in indigenous Malaysians, done by University of Malaya and NIH, on Cell. www.cell.com/cell/fulltex...
Trichophyton concentricum fungal infections and skin microbiomes of Indigenous Peninsular Malaysians
Indigenous Orang Asli of Peninsular Malaysia raised concerns about the etiology, treatment, and transmission routes of the skin disorder tinea imbricata. Analyses of the associated Trichophyton concen...
cell.com
Now online! Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis
Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis
Serotonin transporter (SERT) inhibits CD8 T cell antitumor immunity by depleting intratumoral serotonin. SERT-blocking selective serotonin reuptake inhibitor (SSRI) antidepressants enhance CD8 T cell antitumor immunity and synergize with anti-PD-1, highlighting SSRIs as potential cancer immunotherapeutics.
dlvr.it
👀Preview for Lane et al: Cellular reprogramming by protein degradation: The next frontier in cancer immunotherapy by Anjana Rao @AnjanaRaoLab, Erik Ehinger @erik_ehinger at
The new issue is out! 👉 cell.com/cell/current In this issue of Cell, Yu et al. capture evolution of KoRV-A transcriptional silencing as the virus transitions from a pathogen to a stable endogenous retrovirus. The cover features an adult koala with a joey. 📷 Credit: Currumbin Wildlife Sanctuary
Now online! Integrator loss leads to dsRNA formation that triggers the integrated stress response
Integrator loss leads to dsRNA formation that triggers the integrated stress response
Integrator (INT) prevents the escape of immature RNAPII to ensure full-length mRNA production. INT deficiency causes defects in RNAPII maturation that lead to premature termination, accumulation of immunogenic dsRNA, and activation of the integrated stress response (ISR) observed in patient cells.
dlvr.it
Interested in the latest advancements of #epigenetics of #mammalian early embryogenesis? Then join our upcoming mini-symposium in Freiburg! 📅 April 24, 2025, 14:00-19:00 PM 📌 Max Planck Institute, Freiburg (only on-site!) 🛠️ Organized by: @iovino-lab.bsky.social Register & join free of charge.
Symposium: Epigenetics of early mouse development
We are delighted to invite you to to the second symposium, “Epigenetics of Early Mouse Development”, taking place on April 24, 2025, at the Max Planck Institute of Immunobiology and Epigenetics in Fre...
ie-freiburg.mpg.de