Genes & Development
@genesdev.bsky.social
G&D publishes high-quality research in molecular biology, cancer biology, development, neuroscience and related fields. In addition, G&D also publishes comprehensive Review Articles, Perspectives and Outlooks written by leading scientists.
RESEARCH COMMUNICATION: The Bcl11–Cxxc1 axis regulates stage-specific chromatin accessibility during lymphocyte development By Okuyama et al., and Ichiro Taniuchi ➡️ https://genesdev.cshlp.org/content/40/15-16/1214.abstract RIKEN #transcriptionfactor #lymphocyte #Tcell #Bcell #chromatin
RESEARCH PAPER: LKB1 functions as a checkpoint for neuronal–glial balance during enteric nervous system development By Lucas, Appaix et al., and Chantal Thibert ➡️ https://genesdev.cshlp.org/content/40/15-16/1227.abstract Université Grenoble Alpes Inserm #neurodevelopment #metabolism #glia #neuron
Dr. H. Zoghbi, H. Lee et al explain why the #cerebellum and the #brainStem are more vulnerable than other organs to the harmful effects of defective #ATXN1 protein. #SCA1 #ataxia @bcmhouston.bsky.social @bcmgenetics.bsky.social @genesdev.bsky.social blogs.bcm.edu/2026/07/30/a...
A closer look at brain tissue vulnerability in neurological disease
New evidence explains differences in brain tissue vulnerability using animal models of human spinocerebellar ataxia type 1.
blogs.bcm.edu
🚨 NEW ISSUE ALERT!!! 🚨 New Research articles online now at Genes & Development! Also in this issue, an Outlook on isoform-paralogs in neurodisease, and a Cancer Metabolism Review, and an In Memoriam for Greg Hannon. Click here to learn more: ➡️ https://genesdev.cshlp.org/content/40/15-16.toc
🆕 ADVANCE ONLINE 🆕 REVIEW: Metabolic adaptations of the tumor macroenvironment and their role in cancer progression and survivorship By Devesh Raizada and Ana Gomes ➡️ https://ow.ly/usN750ZunaS Gomes Lab Moffitt Cancer Center #cancer #metabolism
🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Dual regulation of the unfolded protein response by IGF2BP3 during ER stress By Anisimova et al., and Elif Karagöz ➡️ https://ow.ly/66ly50ZuomP Elif Karagöz Max Perutz Labs Vienna Universität Wien / University of Vienna MedUni Wien Vienna BioCenter #ERstress #UPR
🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Functional divergence of Capicua isoforms explains differential tissue vulnerability in neurological disease By Lee et al., and Huda Zoghbi ➡️ https://ow.ly/u0Vu50ZulF2 Baylor College of Medicine HHMI BCM Department of Molecular and Human Genetics
Our manuscript on the dependency of ALT-positive tumors on the DNA translocase SMARCAL1 is finally out in @genesdev.bsky.social. Big thanks again to the Min, Lazzerini Denchi and @cejkalab.bsky.social labs! @angelotaglialatela.bsky.social genesdev.cshlp.org/content/earl...
SMARCAL1 is a candidate therapeutic target for ALT-positive tumors
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
Alberto Ciccia@albertociccia.bsky.social · 6mo agoHappy to share our new pre-print on the dependency of ALT-positive tumors on the DNA translocase SMARCAL1. Outstanding work of @angelotaglialatela.bsky.social in collaboration with the Min, Lazzerini Denchi and @cejkalab.bsky.social laboratories! www.biorxiv.org/content/10.6...
Dr. H Zoghbi, H. Lee et al: certain areas of the #Brain are more vulnerable to disease if a specific protein partnership is disrupted #capicua #ataxia #SCA1 @genesdev.bsky.social @bcmhouston.bsky.social #TexasChildrens @bcmgenetics.bsky.social @bcmneurosci.bsky.social www.bcm.edu/news/researc...
Researchers explain differences in brain tissue vulnerability in neurological disease
Many neurological diseases damage specific parts of the brain, even though the harmful protein involved is present throughout the brain. Researchers at...
bcm.edu
🚨 The @gekaragoz.bsky.social lab uncovers in @genesdev.bsky.social how the RNA-binding protein IGF2BP3 helps cells cope with stress by fine-tuning unfolded protein response, revealing a layer of regulation that determines if cells adapt or fail➡️ tinyurl.com/3fxhxznz @univie.ac.at @meduniwien.ac.at
#ResultatScientifique🔎| La protéine LKB1 joue un rôle essentiel dans la formation du système nerveux entérique 🧠 ✍️ Sakina Torch & Chantal Thibert 📕 @genesdev.bsky.social 👋 @cnrsalpes.bsky.social @inserm.fr @ugrenoblealpes.bsky.social buff.ly/mq7v5oV
Quand la quantité de nutriments détermine la taille et l’architecture des génomes
Le phyto
buff.ly
🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: The basic helix–loop–helix transcription factor TCF4 recruits the Mediator complex to activate gonadal genes and drive ovarian development By O'Neil et al., and Blanche Capel ➡️ https://ow.ly/iU2S50ZukTa Duke University @dukecellbiology.bsky.social
📽️ G&D Tapes 📽️ G&D Author, Lindsey Soles, tells us about how mRNA splicing and 3' end processing coordinate and compete to shape transcriptional output. In this issue of #genesdev: ➡️ https://genesdev.cshlp.org/content/40/13-14/1099.full UC Irvine UC Irvine School of Medicine #mRNA #transcription
🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: PWWP mutants of the transcriptional cofactor JASPer divert promoter and enhancer activities and suppress position effect variegation in Drosophila By Atkinson et al., and Thomas Jenuwein ➡️ https://ow.ly/71Yc50ZtCJb Derek Atkinson @mpi-ie.bsky.social
IN MEMORIAM: Greg Hannon: the scientist who changed biology, and the people who practiced it By Camila dos Santos ➡️ https://genesdev.cshlp.org/content/early/2026/07/21/gad.354062.126.full.pdf+html Camila dos Santos CSHLaboratory
🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: SMARCAL1 is a candidate therapeutic target for ALT-positive tumors By Taglialatela et al., and Alberto Ciccia ➡️ https://ow.ly/BUA150ZoCcg Alberto Ciccia Angelo Taglialatela Columbia University #cancer #telomere #cancertherapy
🆕 ADVANCE ONLINE 🆕 RESEARCH COMMUNICATION: TET1 noncatalytic activity shapes the chromatin landscape associated with de novo methylation establishment in the male germline By Prasasya et al., and Marisa Bartolomei ➡️ https://ow.ly/iHQJ50ZoBLB University of Pennsylvania Penn Medicine #epigenetics
🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Coordination of nuclear RNA processing by speckle-localized kinase TAOK2 By Begg, Tracey et al., and Kristen Lynch ➡️ https://ow.ly/nbBO50ZoBpX University of Pennsylvania Penn Medicine #kinase #nuclearspeckle #RNA #RNAsplicing
🆕 ADVANCE ONLINE 🆕 RESEARCH COMMUNICATION: The Bcl11–Cxxc1 axis regulates stage-specific chromatin accessibility during lymphocyte development By Okuyama et al., and Ichiro Taniuchi ➡️ https://ow.ly/cpsK50ZoxzX RIKEN #transcriptionfactor #lymphocyte #Tcell #Bcell #chromatin
ON THE COVER: MLL4 on the treadmill of chromatin, supporting the stamina of TGF-β signaling. Artwork by Maria De-Castro. Learn more in this study by Chan et al. and Marc Timmers: ➡️ https://genesdev.cshlp.org/content/40/13-14/1012.abstract Timothy En Haw Chan Universität Freiburg @dkfz.bsky.social
🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: LKB1 functions as a checkpoint for neuronal–glial balance during enteric nervous system development By Lucas et al., and Chantal Thibert ➡️ https://ow.ly/3aOa50Zox1A Université Grenoble Alpes Inserm #neurodevelopment #metabolism #glia #neuron #kinase
OUTLOOK: A new perspective on ATR's role in translesion synthesis By Laura Lindsey-Boltz and Aziz Sancar ➡️ https://genesdev.cshlp.org/content/40/13-14/979.full Also read: ➡️ https://genesdev.cshlp.org/content/40/13-14/1059.abstract UNC Biochemistry and Biophysics department #DNAreplication
RESEARCH PAPER: MYC serine 62 phosphorylation promotes its association with DNA double-strand breaks to facilitate repair and cell survival under genotoxic stress By Cohn et al. and Rosalie Sears ➡️ https://genesdev.cshlp.org/content/40/13-14/1152.full Oregon Health & Science University #DNArepair
RESEARCH PAPER: CDK1 and CEP97 cooperatively control centriole length to orchestrate ciliogenesis and developmental patterning By Liu et al. and Jeremy Reiter ➡️ https://genesdev.cshlp.org/content/40/13-14/1133.full UCSF Helen Diller Family Comprehensive Cancer Center Chan Zuckerberg Biohub Network
RESEARCH PAPER: Evolutionarily conserved spliceosome–exosome pathway in nuclear mRNA surveillance By Abbas et al. and Elena Conti ➡️ https://genesdev.cshlp.org/content/40/13-14/1119.full Max Planck Institute of Biochemistry #RNAdecay #splicing #mRNA #RNAsurveillance
RESEARCH PAPER: The competition between splicing and 3′ processing shapes the human transcriptome By Soles et al. and Yongsheng Shi ➡️ https://genesdev.cshlp.org/content/40/13-14/1099.full UC Irvine UC Irvine School of Medicine #RNAprocessing #splicing #mRNA #transcription
📽️ G&D Tapes 📽️ G&D Author, Jeongmin An, tells us about how kinase STK38L serves as a negative regulator of Hippo signaling, and its implications for development and cancer. In this issue of #genesdev: ➡️ https://genesdev.cshlp.org/content/40/13-14/1080.abstract UC Irvine #Hippo #YAP #cancer
RESEARCH PAPER: STK38/L promote tissue growth and cancer by inhibiting the Hippo pathway By An et al. and Wenqi Wang ➡️ https://genesdev.cshlp.org/content/40/13-14/1080.abstract UC Irvine #Hippo #YAP #Drosophila #cancer
RESEARCH PAPER: Coupling of translesion synthesis with the replisome stabilized at stalled replication forks by ATR By Yoon et al. and Satya Prakash ➡️ https://genesdev.cshlp.org/content/40/13-14/1059.abstract UTMB Health #DNAreplication #DNArepair #genomestability #translesionsynthesis
RESEARCH PAPER: Cleavage of the RNA polymerase II general transcription factor TFIIB tunes transcription during stress By Gulyas et al. and Britt A. Glaunsinger ➡️ https://genesdev.cshlp.org/content/40/13-14/1045.abstract UC Berkeley HHMI #transcription #stress #cancer #virus #immunity
