Tim Sheahan
@timothysheahan.bsky.social
PI in #virology working on #coronavirus and #hepacivirus pathogenesis and #antivirals at UNC Chapel Hill. Featured in GQ mag (what the hell?) for #COVID19. Almost over the hill but still love Minor Threat.
Question: how do people track to do lists for lab when it includes grants, papers, meetings, action items to follow up on, reading, class lecture prep etc. I’m having a hard time finding the best mechanism for managing this. #lablife #organization #productivity #todolists #virology #lovevirology
CoV single molecule RdRp paper from the @dulinlab.bsky.social is out at Science Advances. Our contribution led be the amazing Dr. Meghan Diefenbacher www.science.org/doi/10.1126/...
Copy-back RNA synthesis by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir
Helicase-driven copy-back RNA synthesis in coronaviruses reveals how antivirals trap replication intermediates.
science.org
UNC-Chapel Hill Coronavirus Researcher Ralph Baric to Retire Baric’s life’s work paved the way for vaccines against COVID-19. But it brought scrutiny to him, his lab, and UNC-CH in the process.
UNC-Chapel Hill Coronavirus Researcher Ralph Baric to Retire
Baric’s life’s work paved the way for vaccines against COVID-19. But it brought scrutiny to him, his lab, and UNC in the process.
theassemblync.com
SARS-CoV-2 without proofreading are sad and weak viruses. out now in #mBio #lovevirology journals.asm.org/doi/10.1128/...
Loss of nsp14-exonuclease activity impairs the replication, proofreading, fitness, and pathogenesis of SARS-CoV-2 | mBio
Coronaviruses (CoV) are important human pathogens causing hundreds of millions of infections and millions of deaths over the past 20 years. The study of how these viruses multiply and cause disease id...
journals.asm.org
Interesting #flavivirus meeting alert hcv-flavi2026.org @leendelang.bsky.social @msdiamondlab.bsky.social #hcv #virology #viruses
Home - HCV-FLAVI 2026
Days Hours Minutes Seconds Program Registration Abstracts Organizing Committee Social Events Welcome to HCV-Flavi 2026 We warmly invite you to join the 32nd International Symposium on Hepatitis C Viru...
hcv-flavi2026.org
A new paper shows that women, particularly those early in their careers, have been disproportionately affected by NIH grant terminations. www.statnews.com/2026/03/23/n...
NIH grant terminations affected women scientists more than men, study finds
A new paper shows that women, particularly those early in their careers, have been disproportionately affected by NIH grant terminations.
statnews.com
Modeling liver cancer caused by chronic hepacivirus infection. Great collab with Rice Lab @rockefeller.edu heavy lift by Mariana Batista #HCV #HCC #livercancer #cancer #chronicinfection doi.org/10.1016/j.jh...
Better half worked on the approval of J&J #icotrokinra. Happy birthday to Icotyde! My 11 year old made this card! #psoriasis #medicine #drugs #chemistry #IL23
Hiked up to the “Big C” at @ucberkeleyofficial.bsky.social via Cyclotron road. My particles were accelerated once I got to the top #physics #crystalography #biology
Our new preprint on #SARSCoV2 nsp14 #exonuclease function in replication fidelity and fitness. ExoN- viruses are attenuated in vitro and in vivo but w/o #interferon signaling replication is largely restored! Suggests nsp14 plays a role in innate antagonism in vivo www.biorxiv.org/content/10.6...
Loss of nsp14-exonuclease activity impairs the replication, proofreading, fitness and pathogenesis of SARS-CoV-2
Coronaviruses (CoVs) replicate their RNA genomes with increased fidelity than other RNA viruses, a mechanism mediated by the proofreading and recombination activities of the exoribonuclease domain of ...
biorxiv.org
Human coronavirus 229E antibodies and Spike structure function paper is finally out for real. Led by @wrapplab.bsky.social (wrappers delight) and @mlicc1701.bsky.social (MFL) #lovevirology #229E #antibodies www.nature.com/articles/s42...
Client Challenge
nature.com
New #coronavirus #postacute lung pathogenesis paper from my friend Dr. John Powers is up at @asm.org JVI. journals.asm.org/doi/10.1128/... Confusing as to why this link shows a rotund blue bird. #PASC #SARSCoV2 #Omicron #LoveVirology #JVI #ASM #virology
Mouse-adapted SARS-CoV-2 Omicron BA.5 infection induces post-acute lung fibrosis in BALB/c mice | Journal of Virology
To best combat the evolving landscape of SARS-CoV-2 variants of interest and variants of concern, the development of effective small animal models is of critical importance. Herein, we describe the de...
journals.asm.org
Grant writing w ballet rehearsal on the side. #coronavirus #exonuclease is cool shit. Guides replication fidelity and we think masterminds control of the host response. Oh my. If only my 12 pages were done? #grantwriting #acadreamia #nih #coronavirus
New paper about ACE2 using Merbecovirus. Hot stuff. So hot but you can't Letko. @fviromics.bsky.social and Nick Catanzaro. www.nature.com/articles/s41... #ACE2 #emergingviruses #bats #batman #MERS #HKU5
ACE2 from Pipistrellus abramus bats is a receptor for HKU5 coronaviruses - Nature Communications
This work shows that receptor use in merbecovirus is clade-specific by clustering them into clades based on the receptor-binding domain (RBD) of their spike proteins. While MERS-CoV and its close rela...
nature.com
@mattfrieman.bsky.social taped this to my lab notebook almost 20 years ago. It’s not untrue 🤣Vestiges of simpler times. #lovevirology #virology #lablife #sars #laboratory #science #biology #academia
So nice to be teamed up with @wrapplab.bsky.social on this mAb project! It's been a delight. Some may say a Wrapper's Delight? #antibodies #virology #lovevirology #229E #coronavirus #therapeutics #vaccination #emergingviruses
Daniel Wrapp@wrapplab.bsky.social · last yr.Very excited to share our latest preprint describing the isolation and characterization of neutralizing HCoV-229E-directed antibodies from a human donor! Great collaboration between DHVI and the Baric and Sheahan (@timothysheahan.bsky.social) labs at UNC. www.biorxiv.org/content/10.1...
Having a hard time processing this. HHMI is pausing all competitions. Very demoralizing for early career scientists like me @hhmi.org
How much federal research funding has been axed so far in the new administration? An early estimate is $1.8B, but that's likely an underestimate, @aniloza.bsky.social reports. www.statnews.com/2025/05/08/t...
NIH grant terminations under Trump have totaled at least $1.8 billion, analysis finds
Researchers calculated that $1.8 billion in National Institutes of Health grants were terminated in just over one month
statnews.com
How does one determine EC50 w a curve like this? #antivirals #coronavirus #cell www.sciencedirect.com/science/arti...
Thank you @holdenthorp.bsky.social for being a voice which eventually we can hopefully build into a chorus. It's hard to not fall into a daily bleakness black hole (DBBH).
Holden Thorp@holdenthorp.bsky.social · last yr.I've been on the road (and much to come) visiting campuses and giving talks about all the pain. I've been to places where the presidents have been forthcoming with the campus and not. Here's my shot at how to talk to campuses based on what I've learned. open.substack.com/pub/holdenth...
NIH has rescinded its scientific integrity policy. Hard to see this as anything other than clearing the way for shoddy research on things like vaccines. Regardless of the rationale, it's bad news for public health. grants.nih.gov/grants/guide...
NOT-OD-25-080: Rescission of the Final Scientific Integrity Policy of the National Institutes of Health
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Rescission of the Final Scientific Integrity Policy of the National Institutes of Health NOT-OD-25-080. OD
grants.nih.gov
"Angry, disappointed, frustrated"--Scientists were making progress on vaccines and antivirals for the next pandemic--until this week, when the Trump administration abruptly told them to stop. Here's my story with @apoorvanyt.bsky.social Gift link: nyti.ms/43Xz77q
H.H.S. Scraps Studies of Vaccines and Treatments for Future Pandemics (Gift Article)
Federal officials cited the end of the Covid-19 pandemic in halting the research. But much of the work was focused on preventing outbreaks of other pathogens.
nyti.ms
The damage being done to the biomedical community will probably not be appreciated for years
Jon Cohen@cohenjon.bsky.social · last yr....a “pointless, ill-advised move that will hurt U.S. science and pandemic readiness,” says Charles Rice, a Nobel Prize–winning virologist at Rockefeller University www.science.org/content/arti...
I just covered this for @thetransmitter.bsky.social — will keep following! www.thetransmitter.org/funding/fede...
Federal Register hold makes ‘end run’ around court pause on NIH funding freeze
NIH-related updates to the Federal Register, which are required for the scheduling of study sections and advisory councils, are on hold indefinitely, according to an email reviewed by <i>The Transmitt...
thetransmitter.org
Saved from death in the paper grave yard! Started in 2016. MERS-CoV infects epithelial cells, they die, pathology is wicked bad. Adaptive immune cells both control replication and drive pathogenesis. #coronavirus #MERSCoV #pathogenesis #LoveVirology #viruses #virus journals.asm.org/eprint/ZZEIT...
Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity | mSphere
Emerging coronaviruses like SARS-CoV, SARS-CoV-2, and MERS-CoV cause a range of disease outcomes in humans from an asymptomatic, moderate, and severe respiratory disease that can progress to death but...
journals.asm.org
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring www.science.org/content/arti...
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing
science.org
Just when you though Apple’s #Siri was the most annoying and egregiously offensive Siri…https://www.nytimes.com/2024/12/13/health/aaron-siri-rfk-jr-vaccines.html?smid=nytcore-ios-share&referringSource=articleShare&sgrp=c-cb
RFK Jr.’s Lawyer Has Asked the FDA to Revoke Polio Vaccine Approval
Aaron Siri, who specializes in vaccine lawsuits, has been at Robert F. Kennedy Jr.’s side reviewing candidates for top jobs at the Department of Health and Human Services.
nytimes.com
