David Dulin

@dulinlab.bsky.social

Associate prof at VU Amsterdam; single-molecule biophysics; gene machines; #RNAvirus; #transcription; #replication; innate immunity https://daviddulinlab.com/

Come be our colleague. I have been in this Division for 27 years (4 as a postdoc and 23 as a PI). It is an amazing place to work, collaborate, and be inspired. If you are applying to be an Assistant or Associate Professor this Fall, don't miss this deadline.

Fred Hutch Basic Sciences Division@basicsci.fredhutch.org · last mo.

Join @FredHutch.org's Basic Sciences Division as an Assistant or Associate Professor and help shape the future of fundamental biology. We welcome applicants whose work will complement, extend, or bring new directions to the division.

‼️🚨Out now in Molecular Cell - Our latest study 𝐫𝐞𝐯𝐞𝐚𝐥𝐢𝐧𝐠 𝐧𝐞𝐰 𝐢𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐢𝐧𝐭𝐨 𝐅𝐀𝐂𝐓 𝐟𝐮𝐧𝐜𝐭𝐢𝐨𝐧 𝐚𝐧𝐝 𝐭𝐡𝐞 𝐢𝐦𝐩𝐨𝐫𝐭𝐚𝐧𝐜𝐞 𝐨𝐟 𝐧𝐮𝐜𝐥𝐞𝐨𝐬𝐨𝐦𝐞 𝐨𝐫𝐠𝐚𝐧𝐢𝐬𝐚𝐭𝐢𝐨𝐧 𝐟𝐨𝐫 𝟑𝐝 𝐠𝐞𝐧𝐨𝐦𝐞 𝐦𝐚𝐢𝐧𝐭𝐞𝐧𝐚𝐧𝐜𝐞: tinyurl.com/2xctvx38. It was a pleasure to lead this collaborative effort alongside @nilskrietenstein.bsky.social More in🧵below 🪡

Maintenance of nucleosome organization through replication and transcription counteracts aberrant coalescence of active chromatin

Nucleosomes with their associated modifications organize and regulate the genome. It is unclear how this is integrated with the requirement of replica…

tinyurl.com

Finally out! I am super proud of this work that took 6 years to come to fruition, with many amazing people involved, in particular Sadegh, Ibrahim, Jelmer. #SadeghFeiz: all kudos for you to push this project through! Great Collab with Anssi Malinen from @utu.fi @vuamsterdam.bsky.social

bioRxiv Biophysics@biorxiv-biophys.bsky.social · last mo.

A multimodal, correlative magnetic tweezers-TIRF platform for high-throughput single-molecule interrogations https://www.biorxiv.org/content/10.64898/2026.08.11.744120v1

1/11 New preprint from the Sternberg lab in collaboration with the Fernández lab! We are excited to share our structure-function study of DRT10, a bacterial defense-associated reverse transcriptase that synthesizes long tandem-repeat DNA.🧵 Read the full story here: www.biorxiv.org/content/10.6...

Mechanism of tandem-repeat DNA synthesis by an antiviral reverse transcriptase

Defense-associated reverse transcriptases (DRTs) employ DNA synthesis to protect bacteria against phage infection[1][1],[2][2]. We previously showed that DRT10, a tripartite system comprising an RT, a...

biorxiv.org

We are looking for someone to lead the new Facility for Protein Biochemistry & Biophysics at the MPI of Immunobiology and Epigenetics in Freiburg — please spread the word and apply if you are interested!

Max Planck Institute of Immunobiology and Epigenetics@mpi-ie.bsky.social · 3mo ago

🚀 Job alert: We’re starting a new Facility – and you can lead it! The MPI-IE & @mariekeoudelaar.bsky.social are hiring a Head of Protein Biochemistry & Biophysics to launch and lead a brand-new Core Facility in Freiburg 🇩🇪. Once-in-lifetime-chance. Details ⬇️ jobs.ie-freiburg.mpg.de/jobposting/b...

Registration is opened for the FASEB conference DNA Topoisomerases in Biology and Medicine ! July 20th-23rd 2026, Nashville, TN Abstract Submission Deadline: Monday, May 25, 2026 Early Registration Deadline: Monday, June 8, 2026 #DNATopSRC John Nitiss, Valerie Lamour & Keir Neuman

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📢 We are now recruiting a PhD student in Structural and Molecular Virology in Sweden 🇸🇪 Work on RNA viruses using cryo-EM and in situ cryo-ET, with access to world-class microscopy infrastructure Perfect for candidates with backgrounds in biochem, structural bio, and virology More info ⬇️

New preprint from the lab where we derived a simple and robust in situ force calibration method for high throughput #magnetictweezers that works even for short tethers and apply it to understand the mechanism of directional #mitochondrial #transcription termination by MTERF1.

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 5mo ago

Accurate single-bead force calibration in high-throughput magnetic tweezers reveals the mechanism of directional transcription termination by MTERF1 https://www.biorxiv.org/content/10.64898/2026.04.17.719150v1