Sasha A.S.

@toleafgirl.bsky.social

Assistant Professor of Medicine MSc, PhD, FAHA https://cics.bwh.harvard.edu Mass spectrometry Proteomics Opinions are my own, they should be yours too.

What's up, chat! Group chats are rolling out today in the new v1.124 update. This is our first feature built for communities, and there's more to come.

A group chat staffed entirely by the Bluesky team's pets, who are very excited to tell each other that group chats now exist.

This Special Issue was created in honor of Professor Jenny Brodbelt, recipient of the 2024 ASMS John B. Fenn Award for a Distinguished Contribution in Mass Spectrometry. Read the Special Issue and editorial written by JASMS Associate Editor Lingjun Li: go.acs.org/e4o

Promotional graphic with text: SPECIAL ISSUE | Journal of the American Society for Mass Spectrometry logo | 2024 Fenn: Photoactivation and Ion Activation | Read More | ACS Publications logo

I love this photo of astronaut Christina Koch looking back at Earth from Artemis II. She's the first woman to see the full sphere of our beautiful planet. Welcome home to the crew, and thank you for reminding us of all we can discover together.

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There are also seven previous editions of this series available here, along with graphics on contemporary women in chemistry: www.compoundchem.com/category/wom... #InternationalWomensDay

Compound Interest | Chemistry infographics@compoundchem.com · 6mo ago

On #InternationalWomensDay, here's another edition of Women in Chemistry History. This edition features women whose achievements in chemistry include the creation of synthetic emeralds, the impact of diet on intelligence and health, and more: www.compoundchem.com/2026/03/08/i... #ChemSky 🧪

Infographic highlighting the contributions of twelve women in chemistry history. Full alt-text available at the link in the post.

Abstract submission for San Diego was a SUCCESS! 🎉 Like Baltimore 2025, we’ve exceeded 3,400 abstracts. Thank you to everyone who submitted! Abstracts are now under review and notifications will be sent by end of the week. Start planning to join us in San Diego! #TeamMassSpec

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📢 2027 US HUPO Association Awards — Nominations Now Open! 🏆 Celebrate excellence in proteomics — nominate a colleague or deserving leader today! 🙌 💡 Who can nominate: Current US HUPO members 📅 Deadline: October 2, 2026 🔗 Learn more & submit your nomination: us-hupo.org/awards #USHUPO #Proteomics

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(BioRxiv All) Pioneer and Altimeter: Fast Analysis of DIA Proteomics Data Optimized for Narrow Isolation Windows: Advances in mass spectrometry have enabled increasingly fast data-independent acquisition (DIA) experiments, producing datasets whose scale and complexity… #BioRxiv #MassSpecRSS

Pioneer and Altimeter: Fast Analysis of DIA Proteomics Data Optimized for Narrow Isolation Windows

Advances in mass spectrometry have enabled increasingly fast data-independent acquisition (DIA) experiments, producing datasets whose scale and complexity challenge existing analysis tools. Those same advances have also led to the use of narrow isolation windows, which alter MS2 spectra via fragment isotope effects and give rise to systematic deviations from spectral libraries. Here we introduce Pioneer and Altimeter, open-source tools for fast DIA analysis with explicit modeling of isolation-window effects. Altimeter predicts deisotoped fragment intensity as a continuous function of collision energy, allowing a single spectral library to be reused across datasets. Pioneer re-isotopes predicted spectra per scan and combines an intensity-aware fragment index, spectral deconvolution, and dual-window quantification for fast, spectrum-centric DIA analysis. Across instruments, experimental designs, and sample inputs, Pioneer enables high-confidence identification and precise quantification at scale, completing analyses 2-6x faster and maintaining conservative false-discovery rate control.

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Can you explain your PhD research like a story — clear, engaging & jargon-free? Then don’t miss the Three-Minute Thesis Competition at #HUPO2026 🎤 3 minutes Global audience Big impact Submit a lay abstract (≤300 words, no jargon) via the HUPO 2026 portal: 🔗 2026.hupo.org Sponsored by Mass Dynamics

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