Lukas Käll

@lukaskall.bsky.social

Computational Proteomics and Machine Learning fanatic.

So, OpenAI, whose entire business model relies on some overhyped dudebros using vast amounts of stolen data and stolen labour, is releasing a specialised GPT for the life sciences. And naming it, apparently without any sense of irony or self-awareness. Rosalind.

We're hiring! Two fully funded PhD positions are open in my group at KTH/SciLifeLab, both in the intersection between machine learning, mass spectrometry, and proteomics. One EU MSCA-funded, one DDLS. Details below 👇

Open-Source and FAIR in relation to Proteomics to speed up research and innovation, from KTH (@lukaskall.bsky.social) and others pubs.acs.org/doi/10.1021/...

Open-Source and FAIR Research Software for Proteomics

Scientific discovery relies on innovative software as much as experimental methods, especially in proteomics, where computational tools are essential for mass spectrometer setup, data analysis, and interpretation. Since the introduction of SEQUEST, proteomics software has grown into a complex ecosystem of algorithms, predictive models, and workflows, but the field faces challenges, including the increasing complexity of mass spectrometry data, limited reproducibility due to proprietary software, and difficulties integrating with other omics disciplines. Closed-source, platform-specific tools exacerbate these issues by restricting innovation, creating inefficiencies, and imposing hidden costs on the community. Open-source software (OSS), aligned with the FAIR Principles (Findable, Accessible, Interoperable, Reusable), offers a solution by promoting transparency, reproducibility, and community-driven development, which fosters collaboration and continuous improvement. In this manuscript, we explore the role of OSS in computational proteomics, its alignment with FAIR principles, and its potential to address challenges related to licensing, distribution, and standardization. Drawing on lessons from other omics fields, we present a vision for a future where OSS and FAIR principles underpin a transparent, accessible, and innovative proteomics community.

pubs.acs.org

Last week we had our yearly organizational meeting, this time in Vienna, Austria. We had 3 great days discussing the activities of the past year and planning the upcoming ones. Thanks to everyone who joined and contributed to a great meeting!

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I heard this morning that my informatics colleague Dr. Atul Butte passed after a battle with cancer. He was a giant in the field & inspired many of us over his distinguished career. He was a passionate champion of the power of big data & his impact on our field is immeasurable. RIP Atul & thanks.

Wondering about the next step in your proteomics career? Curious to know how proteomics experts ended up at their current positions? Looking for tips to help you discover what you really like? Join our Meet-the-Expert session! Wednesday, June 18th | 12:30 - 13:30 Vauban 2 #EuPA2025 #EuPAFPS2025

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