Our evil ORFeome paper is out! In collaboration with @alex-stark.bsky.social, we screened ~4,000 viral proteins and secreted effectors from bacteria and parasites, covering hundreds of diverse pathogens, for phenotypes in human cells.
Tomas Pachano
@tomaspachano.bsky.social
PostDoc in the Stark lab at the IMP, Vienna. Studying how pathogens rewire human cells
I am thrilled to share our paper out in @cp-cell.bsky.social : "Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways." (1/4) www.cell.com/cell/fulltex...
Systematic discovery of pathogen effector functions across human pathogens and pathways
The eORFeome, a large-scale collection of open reading frames encoding viral proteins and secreted bacterial and parasite effectors, enables functional genomics across diverse pathways and pathogens. ...
cell.com
Pathogens have spent millions of years learning how to hijack human cells. Now, researchers from the Stark lab at the IMP and the Taipale lab at the Donnelly Centre, University of Toronto, have built a platform to systematically discover how they do it:
