We’re delighted to report the publication of our new @nature.com paper, ‘A microexon regulatory code reveals autism-linked genetic variation’, a major collaboration with @quaidmorris.bsky.social & additional colleagues, led by co-first authors @geparada.bsky.social & @ha.nnes.io.

A microexon regulatory code reveals autism-linked genetic variation - Nature

A regulatory sequence code for neuronal microexons reveals genetic variants predicted to alter their splicing in individuals with autism.

can01.safelinks.protection.outlook.com

Although hundreds of viral transcriptional regulators (vTRs) have been identified, we know little about the host pathways they rewire to promote replication and persistence or their mechanisms of action. In our new paper, we addressed this gap across human viruses. 🧵 www.nature.com/articles/s41...

There is still time to apply for the EMBL International PhD Programme! 📢 Don’t miss this opportunity to receive dedicated mentoring while doing interdisciplinary research. Research groups across EMBL are recruiting now! bit.ly/4x9Edss

We’re hiring! Experimental #Postdoc and computational and/or experimental #PhD positions in evolutionary genomics are available in our lab in Heidelberg: home.kaessmannlab.org/openPositions Please repost and spread the word!

WE'RE HIRING! Thanks to some recent successes with NIH funding, we're seeking two new postdoctoral scholars to join our team. See below for details. Please share widely and feel free to reach out with any questions!

New work from the lab! We report that DDIAS is a downstream effector of CIP2A-TOPBP1 in mitosis that suppresses ssDNA to preserve genome integrity. From the great @yiboxue.bsky.social and many collaborators! Free link: authors.elsevier.com/a/1nfiF3vVUP... Pay link: www.cell.com/molecular-ce...

Together with @miketilapia.bsky.social and @jsvanleeuwen.bsky.social we are co-organizing the CSHL 2027 Network Biology meeting (March 9 - 13, 2027) . As in previous years, a large fraction of the talks will be selected from the abstracts. meetings.cshl.edu/meetings.asp...

Network Biology

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

meetings.cshl.edu

Excited to share the results of the Codebook Project, an international effort to identify accurate DNA-binding motifs and genomic binding loci for >300 uncharacterized human transcription factors (TFs) www.nature.com/articles/s41...

An expanded codebook of human transcription factor DNA-binding specificity - Nature

Results from a panel of assays that analyse different aspects of DNA sequence specificity reveal more than 100 new motifs to aid the characterization of putative human transcription factors.

nature.com

Our evil ORFeome paper is out! In collaboration with @alex-stark.bsky.social, we screened ~4,000 viral proteins and secreted effectors from bacteria and parasites, covering hundreds of diverse pathogens, for phenotypes in human cells.

Pathogens have spent millions of years learning how to hijack human cells. Now, researchers from the Stark lab at the IMP and the Taipale lab at the Donnelly Centre, University of Toronto, have built a platform to systematically discover how they do it:

We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...

POSTDOCTORAL FELLOW - Toronto (City), Ontario (CA) job with Taipale Lab, Donnelly Centre, University of Toronto | 12849004

The Taipale lab in the Donnelly CCBR and University of Toronto is looking for a highly motivated Postdoctoral Fellow

nature.com

Our new preprint is online! Viruses, bacteria and parasites use effector proteins to evade immunity and rewire host cell pathways. Together with @AlexanderStark8, we wondered if we could systematically map what these effectors, regardless of their origin, do in human cells. 1/8

Major new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

We are still taking abstract submissions for the network biology CSHL meeting. Plenty of opportunities to present and discuss your research. It's an exciting time to think about what this community can achieve in the next few years.

CSHL Meetings@cshlmeetings.bsky.social · 2y ago

FYI 🔔The abstract deadline for #cshlnetworks is coming up - Jan. 27th! Register to submit your abstract here: bit.ly/40cIfSl @fritzroth.bsky.social @jsvanleeuwen.bsky.social @pedrobeltrao.bsky.social

Postdoc positions in epigenetics! We have several opportunities to investigate big picture questions on (epi)genome function & mechanisms Based @embl.org near Rome (Italy), we offer full scientific support/facilities, training & funding. Also...☀️🏛️🍕🏖️ See👇or contact me for other options. Pls RS