⏳There is less than ONE WEEK to go until our #UbiquitinFunction registration deadline (Tuesday 07 April) 🙋‍♀️Don’t miss your opportunity to register & connect with industry experts, discover fresh insights, & network with like-minded professionals. 🎟️ Register now before it’s too late! bit.ly/3OQhXTY

Good morning!! This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: Systems-level organization of extracellular proteostasis www.science.org/doi/10.1126/...

Registration now open! 2026 #EMBO #Ubiquitin Workshop set in stunning Monopoli, Puglia 🇮🇹 Cutting edge science, great speakers, short talk opportunities, travel awards Limited spaces. Dont miss out - register early! Registration & more info: meetings.embo.org/event/26-ubi...

The E3 ubiquitin ligase mechanism specifying target-directed microRNA degradation (TDMD) is now published! 🎉🍾 We, @bartellab.bsky.social and Schulman lab, describe how 2-RNA factors control protein degradation by recruiting an E3 ligase. @mpibiochem.bsky.social www.nature.com/articles/s41...

Join us for the #Ubiquitin & Friends Symposium 2026, April 29-30, in Vienna! Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot! ➡️ www.protein-degradation.org/symposium/ #ubfriends2026

Molecular glue degraders don't just block proteins; they reprogram cellular recognition logic to eliminate "undruggable" targets entirely. Clues for Glues review by @zkozicka.bsky.social doi.org/10.1042/EBC2...

1 week to go! Würzburg's ready - are You? The GRK2243 Symposium 2025 is just around the corner. Pack your bags, prep your slides, and get hyped! #wUeBI2025

Excited to share our latest study on how K29/K48-branched #ubiquitin chains are forged by the #E3 ligase TRIP12, and how this suggests a consensus mechanism for chain formation by HECT E3s! @natsmb.nature.com 1/7 www.nature.com/articles/s41...

TRIP12 structures reveal HECT E3 formation of K29 linkages and branched ubiquitin chains - Nature Structural & Molecular Biology

Using biochemistry, chemical biology, and cryo-EM, Maiwald et al. elucidate how TRIP12 forms K29 linkages and K29/K48-linked branched ubiquitin chains, revealing a mechanism for polyubiquitylation sha...

nature.com

👏 Fantastic talk by Professor Craig Crews @craigmcrews.bsky.social at the Lund Spring Symposium on the past and future of PROTACs! 🎉 Congratulations on receiving The Special Achievement Award — well-deserved recognition for major contributions to TPD! #TPD #PROTAC #LundSpringSymposium

🗺️ Interactive Map Update! 2 new UK-based labs have been added to the global TPD map: 🔹 Kessler Lab @kesslerbenedikt001.bsky.social 🔹 Fletcher Lab Explore these and many other TPD and ubiquitin labs: 👉 tpd-community.com #TPD #ProteinDegradation #Ubiquitin

🗺️ Interactive Map Update! The Münch Lab @cmunch.bsky.social has joined the global TPD map! 🎉 Explore their work and discover other labs studying #TPD and #ubiquitin biology. 👉 tpd-community.com #ProteinDegradation

🗺️ Interactive Map Update! The map was just updated with 3 more labs from Germany working on TPD: 🔹 Hausch Lab 🔹 Knapp Lab 🔹 Gersch Lab @maltegersch.bsky.social Explore these and other labs advancing TPD and ubiquitin biology: 👉 tpd-community.com #TPD #ProteinDegradation #Ubiquitin

Great to see this out. A story that spanned continents, cities and budget codes… www.nature.com/articles/s41... Big thanks to all the teams involved! @clausenlab.bsky.social @e3chembio.bsky.social

ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213 - Nature Communications

RNF213 is an E3 ligase with ATPase activity. Here, the authors show that RNF213 is activated by ATP binding and senses cellular energy states, and reveal a transthiolation mechanism induced by immune ...

nature.com

🔬 Lab Spotlight: Malte Gersch Lab at Max Planck & TU Dortmund @maltegersch.bsky.social Recent paper: New insights into DUB inhibition & crystallization! 👉 www.nature.com/articles/s41...

Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30 - Nature Structural & Molecular Biology

Kazi et al. report the crystal structure of the mitochondrial deubiquitinase USP30, a clinical stage Parkinson’s disease drug target, in complex with a specific inhibitor. The authors delineate a fram...

nature.com

🧬 Exploring degraders? Check out PROTAC-DB — a free, searchable resource with data on 3,200+ PROTACs, warheads, linkers, E3 ligands, and more. Includes binding data, degradation metrics, ternary structures, and WB images. 🔗 Dive in: cadd.zju.edu.cn/protacdb/ #PROTAC #TPD #DrugDiscovery

Day 1 one #ubfriends2025 was full of great 🎤talks, creative elevator pitches, lively poster sessions and stimulating discussions...

🗺️ TPD Research Map Update! 5 new labs just joined the global TPD map: 🔹 Slabicki Lab 🔹 Kaneko Lab 🔹 Wiener Lab 🔹 Korenblit Lab 🔹 Zhuang Lab Explore these and many other labs working on targeted protein degradation and ubiquitin biology! 👉 tpd-community.com #TPD #ProteinDegradation #Ubiquitin

📢 Next week at the DFCI TPD Seminar (May 15, 12PM EST): 🎙️ Talks by Rebecca Metivier and Martin Steger on using mass spec proteomics to uncover degrader targets. Don’t miss it! #TPD #Proteomics #Degraders

Katherine A Donovan@katherinedonovan.bsky.social · last yr.

Excited to be hosting next week’s DFCI TPD seminar! We’ll hear from two outstanding speakers, Rebecca Metivier and Martin Steger who will share their work on developing and applying mass spectrometry-based proteomics platforms to identify and catalog degrader targets. See you on May 15th @ 12PM EST

PVDF vs Nitrocellulose? How to Choose a Blot Membrane 🤔 If you're optimizing your blots, this guide from Fisher Scientific breaks down when and why membrane matters: 📌 Also includes practical tips for handling and troubleshooting. #WesternBlot #LifeScienceTips

🔬 New from the Itay Koren lab: 💥 TOM20 anchors an E3 ligase to drive UPS-dependent control of mitochondrial fusion/fission via PLD6 degradation. doi.org/10.1038/s415... 👏 Congrats to all authors! 📍 Find the Koren lab + others on our map: tpd-community.com #Ubiquitin #ProteinDegradation

🚨 Next week! The Ubiquitin & Friends Symposium 2025 in Vienna 🇦🇹, May 8–9! Great science, great people, and great event for anyone into ubiquitin & TPD. 🔗 www.protein-degradation.org/symposium/ 👥 Organizers: @sfb-tpd-vienna.bsky.social #TPD #Ubiquitin #ProteinDegradation

Targeted Protein Degradation • From Small Molecules To Complex Organelles

Our Special Research Program is a collaborative research platform to unravel how proteins are targeted for degradation.

protein-degradation.org

🔬 GRK2243 Symposium – Understanding Ubiquitylation 📅 June 2–4, 2025 📍 Würzburg, Germany A 3-day deep dive into ubiquitin biology—from molecular mechanisms to disease and therapeutic strategies. 👥 Hosted by @GRK2243 🔗 Full info: www.ubiquitin-wuerzburg-2025.de #TPD #Ubiquitin #wUeBI2025

🧬 Want to see who’s working on Targeted Protein Degradation or ubiquitin biology? 🔍 Explore our interactive map of research labs worldwide: 🌐 tpd-community.com#the-map Discover labs and find collaborators. #TPD #Ubiquitin #ProteinDegradation #ResearchMap

Welcome to the hub of Targeted Protein Degradation (TPD) and ubiquitin biology. 👋 Connecting the global TPD & ubiquitin biology community. 🔬 Find labs, discover events, and stay in the loop. 🌐 tpd-community.com #TPD #Ubiquitin #ProteinDegradation