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Craig M. Crews

@craigmcrews.bsky.social

75 Posts4244 Follower5910 Folgt
Nobel Prize@nobelprize.org · 5h ago

"I've benefitted in my own lab from having a diverse lab of coworkers." Nobel Prize laureates Andrea Ghez and Carolyn Bertozzi speak about the importance of diversity.

Nature Structural & Molecular Biology@natsmb.nature.com · 2d ago

ICYMI: New online: ATP-independent unfolding of ubiquitin by Ufd1 initiates Cdc48/p97-mediated substrate processing

ATP-independent unfolding of ubiquitin by Ufd1 initiates Cdc48/p97-mediated substrate processing

Nature Structural & Molecular Biology, Published online: 10 September 2026; doi:10.1038/s41594-026-01884-7Wang et al. show that the UT3 domain of Ufd1 binds to and unfolds K48-linked polyubiquitin chains without ATP. Simultaneous binding of two ubiquitins to UT3 is key to overcome the energy barrier. This ubiquitin unfolding is critical for Cdc48/p97’s function.

dlvr.it

Nature Metabolism@natmetabolism.nature.com · 2d ago

RESEARCH | J Tang, E Mills et al (DFCI/HMS; USA) Macrophage-derived itaconate acts as paracrine inhibitor of adipose thermogenesis by blocking succinate uptake into brown adipose tissue🧪

Macrophage-derived itaconate is a negative regulator of adipose tissue thermogenesis - Nature Metabolism

Tang et al. reveal that macrophage-derived itaconate acts as a paracrine inhibitor of adipose tissue thermogenesis by blocking succinate uptake into brown adipose tissue.

dlvr.it

Cell Host & Microbe@cp-cellhostmicrobe.bsky.social · 2d ago

Bacteria promote CaOx stones C. glucuronolyticum-like bacteria enriched in urine of calcium oxalate stone patients & promote CaOx crystallization via hippuric acid degradation & biofilm formation. Hippuric acid prevents bacteria-driven crystallization www.cell.com/cell-host-mi...

Hippuric acid metabolism by Corynebacterium glucuronolyticum-like bacteria promotes calcium oxalate crystallization

Qi et al. identify Corynebacterium glucuronolyticum-like (C. glucuronolyticum-like) bacteria enriched in the urine of calcium oxalate (CaOx) stone patients and show that they promote CaOx crystallizat...

cell.com

SBGrid Consortium@sbgrid.bsky.social · 3d ago

The not so easy job of protecting our DNA: a publication in @natsmb.nature.com from the lab of Nikola Pavletich at @mskcancercenter.bsky.social in which researchers describe the structure of ATR-ATRIP complex bound to its two activators. Read more here: buff.ly/S5IWOVw #SBGrid #DNARepair

The not so easy job of protecting our DNA

SBGrid member Nikola Pavletich reports on the structure of ATR-ATRIP complex bound to two activators, revealing key DNA-damage checkpoints.

medium.com

Dr. Jens Foell@jensfoell.de · 2y ago

Hey friends, I made my first starter pack! You can’t go wrong following these 150 fun and smart science communicators. For some reason there’s no men in there? Weird. Please don’t be mad if you’re not on there — I ran out of slots even though many are still missing 😬 go.bsky.app/JKv3BWU

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EMBL Events@events.embl.org · 3d ago

💻 Our events are hybrid, offering a virtual platform, livestreams, Q&A, online resources, discussions, and recorded talks. This time we also have a bunch of you attending #EMBOChemBio remotely! ⚗️🧬🧪 Session 3: Chemical technologies to manipulate biology ➡️ talks by Mark Brönstrup and Vanessa Rogga

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Harmit Singh Malik@harmitmalik.bsky.social · 4d ago

www.nature.com/articles/s41... “By mining millions of AlphaFold2 models, we identify two human families of ‘superdark’ seven-transmembrane proteins—TM184 and PRRT—with structural homology to G-protein-coupled receptors (GPCRs).”

TM184C is a GPCR-like regulator of intercellular exchange and autophagy - Nature

TM184C—an ancient G-protein-coupled receptor-like superdark protein involved in regulation of autophagy, intercellular connectivity and material exchange—underscores the promise of exploring the under...

nature.com

Trends in Cell Biology@cp-trendscellbio.bsky.social · last wk.

Horizontal mitochondrial transfer: an emerging field in cell biology

Horizontal mitochondrial transfer: an emerging field in cell biology

The field of horizontal mitochondrial transfer (HMT), also referred to as intercellular mitochondrial transfer, has recently gained momentum due to an increasing number of publications that go well beyond diseases such as cancer. From co-culture experiments to in vivo evidence in mouse cancer models, noncancerous diseases, and normal tissue and organ homeostasis and development, it is becoming increasingly clear that HMT is a fundamental physiological phenomenon broadly relevant to complex organisms. Recent methodological advances, epitomized by ultra-high-resolution microscopy and spatial and single-cell multiomics technologies, allow for research that strongly supports HMT as an emerging area of cell biology.

dlvr.it

Ming Tommy Tang@tommytang.bsky.social · last wk.

I hope you've found this post helpful. Follow me for more. Subscribe to my FREE newsletter chatomics to learn bioinformatics divingintogeneticsandgenomics.ck.page/profile

Chatomics! — The Bioinformatics Newsletter

Why Subscribe?✅ Curated by Tommy Tang, a Director of Bioinformatics with 100K+ followers across LinkedIn, X, and YouTube✅ No fluff—just deep insights and working code examples✅ Trusted by grad students, postdocs, and biotech professionals✅ 100% free

divingintogeneticsandgenomics.ck.page

Stephan Hacker@stephanhacker2.bsky.social · last wk.

Amazing paper by the Ed Tate lab with first (and co-corresponding) author @elena-de-vita.bsky.social in @jacs.acspublications.org. A potent and selective covalent RAB27A/B inhibitor with a matched inactive enantiomeric control. pubs.acs.org/jacsat/artic... #ChemSky #ChemBio #DrugDiscovery #Science

Discovery of Stereoselective Targeted Covalent Inhibitors of the RAB27-Effector Protein–Protein Interaction

Abstract. RAB27A and RAB27B are homologous small GTPases that regulate intracellular vesicle trafficking, orchestrating endocytic and exocytic processes th

pubs.acs.org

Hemmo Meyer Lab@hemmo-lab.bsky.social · last wk.

@lsajournal.org doi.org/10.26508/lsa... Paper out: Cool dTAG approach by Dani and Maike for acute perturbation of the #VCP/p97 system nailing down a function during DNA #replication. #ubiquitin. @crc1430.bsky.social @unidue-zmb.bsky.social Thanks to our collaborators, the Beli and Boos labs.

Induced degradation of Ufd1 reveals regulation of cohesin by the VCP/p97Ufd1-Npl4 complex

The AAA ATPase VCP/p97 has emerged as a critical regulator of ubiquitin and chromatin-associated processes but progress in understanding has been hampered by the complexity of p97 functions and the va...

doi.org

Nature Metabolism@natmetabolism.nature.com · last wk.

UBE2N flips the switch on for mitophagy and off for MASH

Nature Metabolism, Published online: 04 September 2026; doi:10.1038/s42255-026-01604-xMitochondrial homeostasis is tightly regulated to prevent hepatocyte injury. In this issue of Nature Metabolism, Wang et al. identify UBE2N as a switch that determines whether hepatocytes undergo protective mitophagy or pathogenic cell death in metabolic dysfunction-associated steatohepatitis (MASH).

dlvr.it

Jeremy Baskin@jeremybaskin.bsky.social · last wk.

Come be my colleague! Cornell Chemistry & Chemical Biology is hiring TWO tenure-track faculty: assistant professor in chemical biology and open rank in quantum materials. Applications due Oct 15 — academicjobsonline.org/ajo/jobs/32602 #chemjobs

Cornell University, Chemistry and Chemical Biology

Job #AJO32602, WDR-00061091 Assistant Professor/Open Rank Professor - Chemistry and Chemical Biology, Cornell University (Ithaca, NY), Chemistry and Chemical Biology, Cornell University, Ithaca, New Y...

academicjobsonline.org