Tobias Rausch
@trausch.bsky.social
Genomics, Bioinformatics. github.com/tobiasrausch
You only have one more week to apply for the EMBL Course #EMBLSBXTech: s.embl.org/sbx26-01-bl This course is designed for wet-lab biologists, scientists, and technicians who work or want to start working in genomics. 🧪 Apply by 27 July Date: 9 – 13 November 2026 Location: EMBL Heidelberg
Wally, our command-line genome alignment plotter, is now available as a client-only web app: no install, no upload, runs entirely in your browser: www.gear-genomics.com/wally/
🎉 #Preprint alert! Excited to share this new study from our postdoc Carsten Hain on centromeres! www.biorxiv.org/content/10.6... This work presents HORoSCOPE, a computational framework that infers centromere architecture and size directly from short-read sequencing data. (1/3)
From @trausch.bsky.social & colleagues in @narjournal.bsky.social #NARWebServerIssue | GEAR Genomics: a user-friendly, #OpenSource web platform enabling interactive genomic analysis 4 molecular biologists | #Bioinformatics #Webserver #OpenScience #Genomics | 🧬🖥️🧪🔓 ⬇️ academic.oup.com/nar/advance-...
GEAR Genomics: a user-friendly, open-source web platform enabling interactive genomic analysis for molecular biologists
Abstract. Many routine genomics tasks in molecular biology still depend on heterogeneous and proprietary software tools that hinder accessibility, reproduc
academic.oup.com
Blog post on "The AI Rewrite Dilemma": lh3.github.io/2026/04/17/t...
The AI Rewrite Dilemma
lh3.github.io
Some Swedish hockey players demonstrate various winter Olympic sports. 😁 (sound on) #Olympics
very sad news. Peer Bork was one of the leaders of our field, a wonderful scientist, and he's much too young to be gone. www.embl.org/news/embl-an...
In remembrance of Peer Bork | EMBL
EMBL and its community are deeply saddened by the death of Peer Bork, the organisation’s Interim Director General.
embl.org
I want to spell this out in case the implications aren't clear: This means all public tools/webapps of GISAID data (all the ones you've been used to seeing thru the pandemic, as far as we can tell) are prohibited. The file allowed this. Cut that - cut off all tools the public & others were using.
Nextstrain@nextstrain.org · 9mo agoOn Oct 1, 2025, GISAID informed us that they had ended updates to the flat file of SARS-CoV-2 genomic sequences and associated metadata that we had used to update Nextstrain analyses since Feb 2020. GISAID's stated rationale was that their "resources are limited". 1/5
Can an AI tool help us better understand the origins of cancer? Researchers from EMBL's Korbel Group have developed a new AI method – MAGIC – which, through a game of molecular laser tag, is shedding light on how chromosomal abnormalities form in cells. www.embl.org/news/science...
Open Team Leader position @embl.org to head & reshape our Genomics Core facility. Interested in providing & developing state-of-the art omics tech to a wide community? A very vibrant, dynamic place to work with fantastic colleagues. Closing Sept 30th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Team Leader – Genomics Core Facility and Method Development
Are you ready to lead a cutting-edge Genomics Core facility while developing state of the art genomics methods? Join us at EMBL! We are seeking talented scientists to develop and lead a cutting-edge G...
embl.wd103.myworkdayjobs.com
We’re looking for curious, innovative science leaders at EMBL Heidelberg! 🔬🧬🦠 Join a vibrant, interdisciplinary community where collaboration and innovation are nurtured at all levels. Take a look at these four open positions 👇
To all post-docs: The Genome Biology dept @embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Group Leader - Genome Biology Unit
Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...
embl.wd103.myworkdayjobs.com
Very nice summary of our latest paper by @samarendra-pani.bsky.social Thanks for all your hard work and outstanding contributions to this project!
Samarendra Pani@samarendra-pani.bsky.social · last yr.[1/8] *New Open-Access Long Read Resource*. We sequenced 1,019 genomes from the 1000 Genomes Project sample cohort using @nanoporetech.com long-read sequencing (LRS) to median 17x coverage. Publication at go.nature.com/4ffPb8f. @hhu.de @crg.eu @embl.org @impvienna.bsky.social
Two papers in today's issue of @nature.com : 1) we assemble 65 genomes to near completion, including centromeres and the MHC. tinyurl.com/3huhax6w. 2) we sequence 1,019 genomes from the 1kGP with long reads, revealing SVs down to low allele frequencies tinyurl.com/wbx3we9x.
Complex genetic variation in nearly complete human genomes - Nature
Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.
tinyurl.com
EMBL researchers and their collaborators have provided exciting new insights into human genetic variation by building upon the 1000 Genomes Project dataset. The two studies constitute what may be the most complete overview of the human genome to date. www.embl.org/news/science...
Now published! Note that since Vikram's original post (quoted here), he's made it easy to dynamically update a set of multi-MUMs (e.g. when more genomes are added to a pangenome) and to find multi-MUMs for huge collections like HPRCv2 genomebiology.biomedcentral.com/articles/10....
Mumemto: efficient maximal matching across pangenomes - Genome Biology
Aligning genomes into common coordinates is central to pangenome construction, though computationally expensive. Multi-sequence maximal unique matches (multi-MUMs) help to frame and solve the multiple...
genomebiology.biomedcentral.com
Vikram Shivakumar@vikramshivakumar.bsky.social · 2y agoExcited to share a preprint for (w/ @benlangmead.bsky.social) our new tool, Mumemto, on biorxiv! Mumemto finds multi-MUMs across pangenomes (i.e. mummer but for pangenomes). It can rapidly visualize synteny, identify misassemblies, and accelerate core genome and multiple alignment, highlighting SVs.
The human pangenome continues to grow and improve! Release 2 is here! Click through for the details, but this is a pretty amazing dataset including not just the phased assemblies, but PacBio HiFi, ONT Ultralong, Dovetail/Illumina Hi-C, PacBio Kinnex, and Illumina WGS for all samples
Human Pangenome Reference Consortium@humanpangenome.bsky.social · last yr.📢 HPRC Release 2 is here! Now with phased genomes from 200+ individuals, a 5x increase from Release 1. Explore sequencing data, assemblies, annotations & alignments in our interactive data explorer ⬇️: humanpangenome.org/hprc-data-re...
SPECIAL ISSUE Part 2! This month @genomeresearch.bsky.social publishes a diverse collection of articles offering novel biological and clinical insights gained using long-read DNA and RNA sequencing technologies and other long molecule approaches. tinyurl.com/Genome-Res-3...
If you’re a #cancer researcher looking to use high throughput sequencing and single-cell technologies, then this course is for you! Make sure you've applied by 9 Feb: www.ebi.ac.uk/training/eve... Some financial assistance is available. See the course page for more info. #OncSky #GeneSky 🧪🖥️🧬
On #WorldCancerDay, we feature how EMBL’s research & services are aiding the fight against cancer. From prediction methods to studying cancer mechanisms – every discovery advances our collective knowledge about this global health challenge. 👇 Learn more: www.embl.org/news/tag/can... 🧪 #cansky
Recruitment for the EMBL International PhD Programme is officially open! 🔊 At EMBL, we train young scientists to become skilled and creative future leaders in academia, industry & other sectors. Start your career in the life sciences with us! www.embl.org/about/info/e... 🧪 #AcademicSky #careers
"Fakten sind das Rückgrat unserer Demokratie." Hier ein Aufruf, der gerne geteilt werden darf: www.openpetition.de/petition/onl...
Fakten sind das Rückgrat unserer Demokratie - Online-Petition
Liebe Mitbürgerinnen und Mitbürger, als Wissenschaftlerinnen und Wissenschaftler arbeiten wir täglich daran, die Grundlagen für fundierte Entscheidungen und Innovationen zu schaffen – basierend auf üb...
openpetition.de
Around genomics, I am looking forward to large scale long read datasets - both Oxford Nanopore and PacBio (COI: I am long established consultant to Oxford Nanopore) where we can get "full" genome representation both for germline and somatic cases. This will transform repeat+structural variant calls
I also deactivated mine.
Universität Bayreuth@unibayreuth.bsky.social · 2y ago#eXit: Today we are sending a joint signal with scientific institutions. Democratic values and science must no longer be misused for algorithmic power games. We switch to Bluesky (@unibayreuth.bsky.social) & Mastodon (@unibayreuth@wisskomm.social). #WissXit #ByeByeX #QuitX
Athenaeum Dietrich Götze Stiftung has generously supported EMBL’s childhood leukaemia research. 🧪 Scientists hope that cell markers they discovered help to understand disease relapse better and lead to more effective treatment. #EMBL50 #MolBiol #Leukemia www.embl.org/news/connect...
12 moments of philanthropy: #12 New frontiers in childhood cancer research | EMBL
The Athenaeum Dietrich Götze Stiftung fuels impactful EMBL research that aims to better understand treatment-resistant childhood leukaemia.
embl.org
Before Christmas I did threads on the application areas of genomics in rare disease (bsky.app/profile/ewan...) and in common disease (bsky.app/profile/ewan...) - now I am going to focus on Cancer genomics
Ewan Birney@ewanbirney.bsky.social · 2y agoI want to provide an overview and perspective of rare disease genomic testing, which is a real success story of science impacting health - a science which goes back over 100 years and yet is still striding forward and much more to come.
Sometimes you just have to persevere through negative reviews. Reviewers, please be kind :) #methodsmatter bit.ly/gs2-scholar
The preliminary #eshg25 program is online. Stellar line-up of invited speakers - full breadth of our amazing field. Grateful to a wonderful SPC @eshg that made this possible. See you all in Milan next year! 2025.eshg.org/programme-at...
Programme at a Glance
Pre-conference courses Thursday, May 22, 2025 & Friday, May 23, 2025 - TBA Conference programme Saturday, May 24, 2025 08:30 - 10:00 Educational Sessions E01 E01 Single cell genomics and diseases W...
2025.eshg.org
