Do psychiatric symptoms in epilepsy always arise from seizures? In ALDH7A1 models, seizure risk traced to the liver; mood-related behavior to astrocytes. One gene. Two tissues. Two pathophysiologies. Neither begins in neurons. New in Science Advances: doi.org/10.1126/scia... 1/11

Astrocyte redox imbalance underlies prelimbic neuronal hypoactivity and maladaptive affective behaviors in epilepsy

Astrocyte antioxidant imbalance reduces neuronal activity, driving depression-like behavior in epilepsy dissociable from seizures.

doi.org

🚨🚨ATTENTION NEUROSCIENCE POSTDOCS!!🚨🚨 UMass Chan’s Department of Neurobiology is searching for applicants for our inaugural UMass ChanNELS series! For more information and to apply: docs.google.com/forms/d/e/1F...

A study by Dorothy P. Schafer, PhD, and Travis E. Faust, PhD, in Cell explains how cell types in the brain communicate in response to changes in sensory input to remodel synapses: direc.to/nJHH Alzheimer’s and ALS patients have synaptic damage. @travisfaust.bsky.social @cp-cell.bsky.social

UMass Chan scientists show how the non-neuronal brain cells communicate to coordinate rewiring of brain

A study by Dorothy P. Schafer, PhD, and Travis E. Faust, PhD, explains how two different cell types in the brain communicate in response to changes in sensory input.

direc.to

Thrilled to share our new paper @cp-cell.bsky.social: “Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.” This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling. 🔗 www.cell.com/cell/fulltex... Faust et al., Cell 2025

Faust, Brenner et al. @harvardmed.bsky.social show that type I IFN signaling contributes to #arthritis pathogenesis in obesity through activation and expansion of CD8 T cells in visceral adipose tissue and synovium. rupress.org/jem/article/... #Autoimmunity

Thrilled to announce that my lab is now open at Ohio State! We study astrocytes as gene therapy targets for brain repair after ischemic stroke and in vascular dementia, developing new viral tools along the way. If you're interesting in joining or collaborating, please reach out! gleichmanlab.com

go.bsky.app/Lyzro3M !WELCOME! thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list. apologies for missing many of you - please do reply to get added and remember to repost so the newbies can find us!