Shane Liddelow
@liddelowsa.bsky.social
Neuroscientist and glial aficionado at NYU Grossman School of Medicine/NYU Langone Health in NYC. Posts in my individual/personal capacity. My lab is full of awesome people doing amazing stuff - check them out: www.liddelowlab.com he/him
Exciting paper alert. Bravo to @borderbiologist.bsky.social and everyone who worked on the paper.
Theodore (Teddy) Fisher@borderbiologist.bsky.social · 8h agoI'm excited to share our latest preprint from the Liddelow lab! We show that specific cytokines can induce astrocytes to present antigens to CD4+ T cells. More proof that astrocytes can actively shape adaptive immune responses during neuroinflammation. @liddelowsa.bsky.social lnkd.in/gjteXwFu
Just a short walk from outside the poster hall to inside the poster hall at #FENS2026 🫠 On the plus side: getting my steps in for extra patatas bravas later 😬
One to watch, and one to join! New lab alert. Go A Prof Prakash!
Priya Prakash@pryprk.bsky.social · 2mo agoI am excited to share that I will be opening my lab as a tenure-track Assistant Professor in the Department of Pharmacological Sciences at Stony Brook University Renaissance School of Medicine, beginning in March 2027. @stonybrooku.bsky.social @stonybrookmedicine.bsky.social www.prakash-lab.org
Interested in finding your own astrocyte networks? The plasmid is now available on Addgene! www.addgene.org/252501/ Check out how we implemented it in this paper, published in Nature: www.nature.com/articles/s41... Need extra guidance? Watch this space for a more detailed protocol paper soon!
Astrocytes connect specific brain regions through plastic networks - Nature
Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.
nature.com
Sorry all, some gliaseq datasets went down over the weekend. They should be up and functioning again soon (if not already). Please do reach out if there are additional bugs. MORE data coming soon!
David Rose: And For That I Am Apologetic
ALT: David Rose: And For That I Am Apologetic
static.klipy.com
Astrocytes do so much more than any of us thought - they even communicate among specific brain regions across hemispheres! The journey to this paper spanned nearly a decade, but I'm most excited to see what everyone else does with the tools we've built. There's so much for all of us to explore!
Astrocytes connect specific brain regions through plastic networks - Nature
Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.
nature.com
Feeling like learning about a secret astrocyte network in the brain? Check out the latest from @melcooperphd.bsky.social in @nature.com. www.nature.com/articles/s41... (take two because I'm out of action on the socials!)
Astrocytes connect specific brain regions through plastic networks - Nature
Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.
nature.com
Congratulations Melissa Cooper, PhD of NYU Langone Health, a 2026 New Vision Research Awardee! Her $100K grant will fund “Astrocyte Networks in Alzheimer’s Disease” exploring how brain cell networks drive disease and reveal new therapies. #CCAD2026 #AlzheimersResearch
I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.
AMAZING PAPER ALERT! www.nature.com/articles/s41... congratulations to @margheritazamboni.bsky.social, @ellorens.bsky.social, and the rest of the team. This one is important and opens up lots of opportunityes.
The regulatory code of injury-responsive enhancers enables precision cell-state targeting in the CNS - Nature Neuroscience
Zamboni et al. reveal how enhancers encode cell-type-specific responses to CNS injury. By combining multiomic profiling, deep learning and in vivo screening, they uncover injury-responsive enhancer lo...
nature.com
Read about one of the fantastic postdocs in the lab - @pryprk.bsky.social. Thanks to The Scientist for running this exciting series! Priya is on the job market atm - so keep your eyes peeled for exciting things to come from her lab soon! :-)
Priya Prakash@pryprk.bsky.social · 8mo agoI was featured on The Scientist as a part of their 'Postdoc Portraits' series where I spoke about my scientific career path and ongoing work on oligodendrocyte dysfunction in neurodegeneration. Check it out! www.the-scientist.com/postdoc-port...
#SfN #SocietyForGlia #Astrocytes ENDING STRONG in Astrocyte land here in San Diego. Thanks for being an amazing community, and apologies (one last time) for anyone I missed! Please comment below with extra awesome astrocyte sessions. See you in 2026!
#SfN #SocietyForGlia STARTING NOW! Ending strong with the last www.liddelowlab.com presentations of the week. @pryprk.bsky.social talking about a world first mouse model for XDP... and OLIGODENDROCYTES! @melcooperphd.bsky.social presenting on astrocyte networks in the mouse forebrain.
#SfN25 #SocietyForGlia #Astrocytes IT'S A BIG DAY - if you're unsure what do do this afternoon - it seems just going to poster row C is the best way to spend some time! as always, apologies to those I have missed - please comment below with more sessions and presentations!
IT'S A BUSY AFTERNOON FOR THE LAB! @mrodea.bsky.social - astrocyte chromatin in reactive astrocytes across the forebrain Nick Kathman - COCKROACH BRAIN ALERT! (is this the largest single cell atlas of an insect brain?) @liddelowsa.bsky.social - multiomic approaches to study astrocyte reacitivity
#SfN25 #SocietyForGlia #Astrocytes Monday is a BUSY day - see you all out there! (apologies for anyone's presentation I missed - please comment below with details)
#SocietyForGlia #SfN25 #Astrocytes Sunday is a rest day for astrocytes it seems - but still lots of cool stuff to go and see. Apologies again for anyone I missed - please link your presentations below
#SocietyForGlia #SfN25 #Astrocytes Astrocyte presentation round up for Day 1. Sorry if I missed anyone, please comment below with others! See you about the conference
#SfN25 #SocietyForGlia #Astrocytes @borderbiologist.bsky.social presenting now! Come and learn about a new function for a substate of reactive astrocytes - antigen presentation!
Very happy to have contributed to this new review on Lewy body dementia in @thelancetneuro.bsky.social led by Sonja W. Scholz. We highlight the latest advances in genetics and pathology. @liddelowsa.bsky.social Check it out! www.sciencedirect.com/science/arti...
Advances in the genetics and pathology of Lewy body dementia
Lewy body dementia is a heterogeneous disease that is underdiagnosed and poorly understood. Pathologically, Lewy body dementia is characterised by the…
sciencedirect.com
In case you were wondering what to do with precisely 150 minutes of your existence @sfn.org #SfN25 #SanDiego. Join our mini-symposium Single-Cell Multiomics in CNS Injury and Recovery. Guaranteed to contain many glial cells and at least a neuron. I am Co-chairing with Naomi Habib
Shane Liddelow@liddelowsa.bsky.social · 9mo ago@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below. Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social. (1/2)
@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below. Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social. (1/2)
If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal! Date: Monday, Nov 17th Time: 9PM till close Location: The Smoking Gun SD, 555 Market St. All welcome, please free to spread the word!
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com www.nature.com/articles/s41...
Spatial dynamics of brain development and neuroinflammation - Nature
A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.
nature.com
Oligodendrocytes support functional development of subcortical premotor neurons and navigation https://www.biorxiv.org/content/10.1101/2025.11.01.686017v1
We've been doing some amazing stuff outside the astrocyte realm. Check out our latest Oligo investigation led by @pryprk.bsky.social !
Priya Prakash@pryprk.bsky.social · 10mo agoI am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene. Read our two companion papers: 🔹 www.biorxiv.org/content/10.1... 🔹 www.biorxiv.org/content/10.1... 🧵 Highlights below!
