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Tuhina Neogi, MD, PhD

@tuhinaneogi.bsky.social

Rheumatologist & Epidemiologist Researcher in #osteoarthritis & #gout | Prof. of Medicine & Epidemiology | Chief of Rheumatology | 🇨🇦 | Boston University Chobanian & Avedisian School of Medicine & Boston Medical Center #RheumSky #MedSky #Rheumatology

39 Posts1221 Follower887 Folgt
Kelsey H. Collins@kelseyhcollins.bsky.social · 10mo ago

Honored to share our new paper, Osteoarthritis as a Systemic Disease, in @natrevrheum.nature.com, out today: rdcu.be/eSXLW - thanks to Ida Haugen, @tuhinaneogi.bsky.social and @farsh-g.bsky.social for your input on gaps and opportunities.

Osteoarthritis as a systemic disease

Nature Reviews Rheumatology - Emerging evidence suggests a paradigm shift in viewing osteoarthritis (OA) as a systemic, bidirectional disease. This Review examines the current data supporting this...

rdcu.be

BU/BMC Rheumatology@bu-bmc-rheum.bsky.social · last yr.

Thanks to @medscape.com for highlighting our work www.medscape.com/viewarticle/...

Calcium Deposition Can Increase Osteoarthritis Risk

A new analysis suggests that chondrocalcinosis is a cause, rather than just a consequence, of knee osteoarthritis.

medscape.com

BU/BMC Rheumatology@bu-bmc-rheum.bsky.social · last yr.

New publication from @rheumcat.bsky.social @tuhinaneogi.bsky.social in collaboration with @curlygeneticist.bsky.social ard.eular.org/action/showP...

Chondrocalcinosis and incident knee osteoarthritis: findings from 2 large prospective cohorts with 20 years of follow-up Yahong Wu, Jean W. Liew, Justin D. Boer, Maggie Westerland, Michael LaValley, Trudy Voortman, Sita Bierma-Zeinstra, Edwin H.G. Oei, Joyce B.J. van Meurs, Tuhina Neogi, Cindy G. Boer
Maureen Dubreuil, MD MSc@spondymd.bsky.social · 12mo ago

✅ IS takes places following efficacy and effectiveness studies, within controlled settings and in practice. 3 types of hybrid IS studies: Type 1: primary aim is to determine effectiveness, Type 2: Codetermining effectiveness & feasibility, Type 3: focuses on implementation

Maureen Dubreuil, MD MSc@spondymd.bsky.social · 12mo ago

PARIHS is a determinant framework based on the concept that implementation is a function of: A. Evidence (research, clinical expertise, patient preferences), B. Context (setting, resources) and C. Facilitation through influence and relationships.

Maureen Dubreuil, MD MSc@spondymd.bsky.social · 12mo ago

CFIR (consolidated framework for implementation research) is a determinant framework addresses the inner and outer settings, the implementation process, the innovation and the individuals’ roles and characteristics. implementationscience.biomedcentral.com/articles/10....

The updated Consolidated Framework for Implementation Research based on user feedback - Implementation Science

Background Many implementation efforts fail, even with highly developed plans for execution, because contextual factors can be powerful forces working against implementation in the real world. The Consolidated Framework for Implementation Research (CFIR) is one of the most commonly used determinant frameworks to assess these contextual factors; however, it has been over 10 years since publication and there is a need for updates. The purpose of this project was to elicit feedback from experienced CFIR users to inform updates to the framework. Methods User feedback was obtained from two sources: (1) a literature review with a systematic search; and (2) a survey of authors who used the CFIR in a published study. Data were combined across both sources and reviewed to identify themes; a consensus approach was used to finalize all CFIR updates. The VA Ann Arbor Healthcare System IRB declared this study exempt from the requirements of 38 CFR 16 based on category 2. Results The systematic search yielded 376 articles that contained the CFIR in the title and/or abstract and 334 unique authors with contact information; 59 articles included feedback on the CFIR. Forty percent (n = 134/334) of authors completed the survey. The CFIR received positive ratings on most framework sensibility items (e.g., applicability, usability), but respondents also provided recommendations for changes. Overall, updates to the CFIR include revisions to existing domains and constructs as well as the addition, removal, or relocation of constructs. These changes address important critiques of the CFIR, including better centering innovation recipients and adding determinants to equity in implementation. Conclusion The updates in the CFIR reflect feedback from a growing community of CFIR users. Although there are many updates, constructs can be mapped back to the original CFIR to ensure longitudinal consistency. We encourage users to continue critiquing the CFIR, facilitating the evolution of the framework as implementation science advances.

implementationscience.biomedcentral.com

Maureen Dubreuil, MD MSc@spondymd.bsky.social · 12mo ago

Proctor’s Conceptual model spans the intervention 💡, strategies 🧩, outcomes 🛠️ and efficacy/effectiveness 📊. pmc.ncbi.nlm.nih.gov/articles/PMC...

Outcomes for Implementation Research: Conceptual Distinctions, Measurement Challenges, and Research Agenda

An unresolved issue in the field of implementation research is how to conceptualize and evaluate successful implementation. This paper advances the concept of “implementation outcomes” distinct from s...

pmc.ncbi.nlm.nih.gov

Tuhina Neogi, MD, PhD@tuhinaneogi.bsky.social · last yr.

I was in non-stop meetings (as usual) and when I finally got to look at emails just now, I was excited to see that it was that time of year again: #ACR25 #EmailConfetti! Congratulations on everyone’s acceptances!

a bunch of colorful squares are flying in the air

ALT: a bunch of colorful squares are flying in the air

media.tenor.com

Rheum Cat@rheumcat.bsky.social · last yr.

Okay it's time to mute #ACR25 if you don't care about rheumatology updates. I will be posting with that hashtag about the American College of Rheumatology meeting in Chicago in October, w increasing frequency as we get closer to it. Today we got our #EmailConfetti - notifications about abstracts

ACR Journals@acr-journals.bsky.social · last yr.

Editorial in A&R "Kerschbaumer & colleagues have introduced a new issue to consider in evaluating large multicenter randomized trials, spotlighting the high rates of placebo response, rates that are threatening the ability to detect efficacy of rheumatic disease treatments." doi.org/10.1002/art....

"Kerschbaumer and colleagues have introduced a new issue to consider in evaluating large multicenter randomized trials, spotlighting the high rates of placebo response, rates that are threatening the ability to detect efficacy of rheumatic disease treatments."
ACR Journals@acr-journals.bsky.social · last yr.

Analysis of psoriasis and PsA trials investigated to what extent global recruitment patterns impact response rates in placebo arms. Expansion of recruitment to less affluent countries may increase placebo rates owing to higher perceived benefit in these countries A&R doi.org/10.1002/art.... #medsky

Time trends of normalized per capita gross-national-income (international Dollars) of placebo-controlled studies from 1996 to 2020, separated by disease (Panel A: psoriatic arthritis; Panel B: plaque psoriasis). Time trends of placebo response rates over time are shown in Panel C (psoriatic arthritis) and Panel D (plaque psoriasis). Panel A+B: each dot represents the weighted, normalized gross-national-income of an individual study. Panel C+D: Each bubble represents the placebo response rate of one individual study. The size of the bubbles represents the number of patients analyzed in the respective placebo arm.