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Chemistry at the University of Illinois Chicago

@uic-chemistry.bsky.social

Advancing sustainability, health, and education through innovative chemistry research at Chicago's only public research institution. Official account for the Department of Chemistry at University of Illinois Chicago. chem.uic.edu

19 Posts930 Follower1430 Folgt
Ruixuan Gao@ruixuan3.bsky.social · 10mo ago

(1/x) Excited to report VIPS (Volumetric imaging of biological specimens via photochemical sectioning) @science.org! VIPS uses light-based sample sectioning to eliminate the inherent imaging depth limit of high-resolution optical microscopes @supgokul.bsky.social: www.science.org/doi/10.1126/...

Mesoscale volumetric fluorescence imaging at nanoscale resolution by photochemical sectioning

Optical nanoscopy of intact biological specimens has been transformed by recent advancements in hydrogel-based tissue clearing and expansion, enabling the imaging of cellular and subcellular structure...

science.org

Chemistry at the University of Illinois Chicago@uic-chemistry.bsky.social · last yr.

New #JACS from the Adibekian Lab, making it the 3rd JACS from #UIC Chemistry this week! 🍾🍾🍾 Read it here: pubs.acs.org/doi/10.1021/... @jacs.acspublications.org #Chemsky

Proteome-Wide Covalent Targeting of Acidic Residues with Tunable N-Aryl Aziridines

Carboxylate side chains in aspartic and glutamic acids play critical roles in protein structure and function due to their polarity and negative charge. These acidic residues, which are abundant in hig...

pubs.acs.org

Chemistry at the University of Illinois Chicago@uic-chemistry.bsky.social · last yr.

🚨 New paper alert from the Nguyen lab at #UIC! @jacs.acspublications.org #chemsky

Andy I. Nguyen@andy-i-nguyen.bsky.social · last yr.

We are excited to announce our #JACS paper on frameworks with metalloprotein-like sites! ɑ-helices designed to assemble by metal-coordination and the hydrophobic effect. Point mutations yield unique frameworks with diverse metalloprotein-like sites. Article: tinyurl.com/jk62cb27 #Chemsky

Chemistry at the University of Illinois Chicago@uic-chemistry.bsky.social · last yr.

The Cho group at hashtag #UIC discovered that many colorectal cancers driven by APC loss depend on high membrane cholesterol to activate β-catenin signaling. Blocking cholesterol–Dishevelled interaction halted tumor growth without harming normal cells. #Chemsky tinyurl.com/mc5prces

Cholesterol-targeting Wnt–β-catenin signaling inhibitors for colorectal cancer - Nature Chemical Biology

Locally elevated cholesterol in colorectal cancer cells with adenomatous polyposis coli truncation was observed to drive Wnt–β-catenin signaling through Dishevelled (Dvl). Inhibitors targeting the cho...

tinyurl.com

Chemistry at the University of Illinois Chicago@uic-chemistry.bsky.social · last yr.

New work from the Mankad group, published in #JACS, reveals that a bimetallic complex can generate the very rare Al(II) oxidation state that can activate CO2.

Neal Mankad@metallacycle.bsky.social · last yr.

Hey #chemsky our latest Al-Fe research is published in @jacs.acspublications.org. Led by Roushan Singh @uic-chemistry.bsky.social and our collaboration with Dan Ess of BYU, we are starting to map the chemistry of Al(II) through this mild approach! doi.org/10.1021/jacs...

Chemistry at the University of Illinois Chicago@uic-chemistry.bsky.social · last yr.

New work from the Adibekian group at UIC out in @J_A_C_S! "Chemoproteomics-Enabled De Novo Proteolysis Targeting Chimera Discovery Platform Identifies a Metallothionein Degrader to Probe Its Role in Cancer" Read it here: pubs.acs.org/doi/10.1021/...

Chemoproteomics-Enabled De Novo Proteolysis Targeting Chimera Discovery Platform Identifies a Metallothionein Degrader to Probe Its Role in Cancer

Proteolysis targeting chimeras (PROTACs) represent powerful tools to modulate the activity of classically “undruggable” proteins, but their application has been limited to known ligands and a few sele...

pubs.acs.org

Neal Mankad@metallacycle.bsky.social · last yr.

Is there a metal-metal bond in Fp2? Check out our latest @pubs.acs.org publication to learn more: pubs.acs.org/doi/10.1021/... Thankful to collaborate with @chemmatcars.bsky.social to do the analysis 💎 #chemsky

Comprehensive Re-examination of Intermetallic Charge Density for the Metal Carbonyl Dimers Mn2(CO)10 and [(η5-C5H5)Fe(CO)2]2

In this study, we have employed high-resolution charge density (HRCD) techniques using X-ray diffraction data collected at 10 K to reanalyze the intermetallic electron density topologies of two repres...

pubs.acs.org

Julia Oktawiec, PhD@joktawiec.bsky.social · 2y ago

I am so excited for this opportunity! Also, very grateful to the support from past and current mentors—particularly my PhD advisor Jeff Long and my postdoc mentor Nathan Gianneschi, but also many others along the way.

Chemistry at the University of Illinois Chicago@uic-chemistry.bsky.social · 2y ago

We are excited to welcome Julia Oktawiec @joktawiec.bsky.social to our faculty! The Oktawiec Lab will interface synthetic peptide-based oligomers, dendrimers, and polymers with coordination chemistry to design novel nanomaterials for sustainability and health. oktawieclab.com

Chemistry at the University of Illinois Chicago@uic-chemistry.bsky.social · 2y ago

🚨 Now in #JACS : The Ayitou lab at #UIC has reported the first aerobic photon upconversion using all-organic donor-acceptor chromophores, which can perform doublet-to-triplet energy transfer (DTET). Read it here: tinyurl.com/3ycxa4rf

Doublet Spin State Mediated Photoluminescence Upconversion in Organic Radical Donor-Triplet Acceptor Dyads

Donor–acceptor dyads are promising materials for improving triplet-sensitized photon upconversion due to faster intramolecular energy transfer (ET), which unfortunately competes with charge transfer (...

tinyurl.com