We’re hiring an optical systems engineer / scientist to help build and disseminate Altair, our open, modular light-sheet microscopy platform. Ideal for someone with serious hands-on experience in optical design, Zemax, CAD, alignment, and microscopy. Apply here: www.linkedin.com/jobs/view/44...

MOSAIC: a versatile multimodal microscopy that seamlessly transitions between light-sheet, 2-photon, label-free and super-resolution modalities. @supgokul.bsky.social www.nature.com/articles/s41...

A multimodal adaptive optical microscope for in vivo imaging from molecules to organisms - Nature Methods

MOSAIC is a versatile multimodal microscope that allows seamless transition between various light-sheet, two-photon, label-free and super-resolution modalities. It is demonstrated in various systems r...

nature.com

The MOSAIC paper is out in Nature Methods. For the record I went after this paper for *years* and was so happy when they sent it to me/us. www.nature.com/articles/s41...

A multimodal adaptive optical microscope for in vivo imaging from molecules to organisms - Nature Methods

MOSAIC is a versatile multimodal microscope that allows seamless transition between various light-sheet, two-photon, label-free and super-resolution modalities. It is demonstrated in various systems r...

nature.com

What membrane properties do cells maintain through regulation of lipid metabolism? In a new paper, we identify intrinsic curvature stress as one such parameter and show how different (eukaryotic) cell types employ different lipids to do that www.cell.com/cell-reports...

Active regulation of intrinsic curvature by eukaryotic phospholipid metabolism

Cells maintain membrane function by actively balancing the molecular shape of their lipids. Milshteyn et al. find that, when subjected to high hydrostatic pressure, yeast and human cells, but not bact...

cell.com

📷 Expansion microscopy turns 11 — and our comprehensive Primer is now live in @natrevmethodsprimers.nature.com ! A decade of ExM, 1000+ papers, and still accelerating. Co-authored with the father of the field, @eboyden3.bsky.social , + Ha Vo & Rong Xu. 📷 Free to read: rdcu.be/fdQPH

Expansion microscopy

Nature Reviews Methods Primers - Expansion microscopy enhances conventional imaging by physically enlarging samples within a hydrogel matrix, surpassing diffraction limits. In this Primer, Vo et...

rdcu.be

I've been leading a big project at Methods in Enzymology over the past year or so: editing three back-to-back-to-back volumes of articles describing the latest advances in methods for studying lipids and membranes — thank you to the 50 #lipidtime luminaries who contributed the 51 chapters! Details 👇

Have you wondered how alcohol affects your emotions and behavior in the long run? How does (excessive) alcohol exposure trigger changes in the brain at the molecular, cellular, and circuitry levels?

We have two funded postdoctoral positions available. Topics encompass: -Next gen light-sheet fluorescence microscopy instrumentation -Structured illumination microscopy and other approaches to extend the resolution limit. -Nonlinear microscopy combined with adaptive optics / phase conjugation

🔬🔦Check out our ‘Imaging spotlight’ on Volumetric Imaging via Photochemical Sectioning (VIPS) from @ruixuan3.bsky.social, Srigokul Upadhyayula and colleagues. VIPS helps researchers scale super resolution imaging to large whole-mount tissues. focalplane.biologists.com/2025/12/02/i...

Imaging spotlight: Volumetric Imaging via Photochemical Sectioning (VIPS) - FocalPlane

Imaging spotlight: Volumetric Imaging via Photochemical Sectioning (VIPS) - Tools

focalplane.biologists.com

Thrilled to share our Science cover! VIPS (volumetric imaging via photochemical sectioning) eliminates working-distance limits for whole-mount, nanoscale imaging. LLSM + photodegradable hydrogel + petabyte-scale compute → mapped axons & myelin across two mouse olfactory bulbs (WT vs NPC1).

A new method called VIPS enables organ-wide nanoscale reconstruction for quantitative mapping of connectivity and molecular landscape in intact tissue. Learn more this week in Science: https://scim.ag/4n4GKPm

(1/x) Excited to report VIPS (Volumetric imaging of biological specimens via photochemical sectioning) @science.org! VIPS uses light-based sample sectioning to eliminate the inherent imaging depth limit of high-resolution optical microscopes @supgokul.bsky.social: www.science.org/doi/10.1126/...

Mesoscale volumetric fluorescence imaging at nanoscale resolution by photochemical sectioning

Optical nanoscopy of intact biological specimens has been transformed by recent advancements in hydrogel-based tissue clearing and expansion, enabling the imaging of cellular and subcellular structure...

science.org