UW Genome Sciences
@uwgenome.bsky.social
The Department of Genome Sciences at The University of Washington
Replaying germinal center evolution on a quantified affinity landscape www.cell.com/cell/fulltex...
Replaying germinal center evolution on a quantified affinity landscape
Antibody affinity maturation results from a somatic evolutionary process that takes place in the germinal center. A “parallel replay” experiment on germinal center B cells reveals the evolutionary for...
cell.com
A global map for introgressed structural variation and selection in humans pubmed.ncbi.nlm.nih.gov/42275491/
A global map for introgressed structural variation and selection in humans - PubMed
Genetic introgression from Neanderthals and Denisovans shaped modern human genomes; however, introgressed structural variants (SVs ≥ 50 base pairs) remain challenging to discover. We integrated high-q...
pubmed.ncbi.nlm.nih.gov
Congratulations to the winners of the GS outstanding Service Award: Bonny Brewer (faculty), Josh Malamy (staff), Joe Min (student), and Ryan Friedman (postdoc)!
Congratulations to Joe Felsenstein on being elected to the Fellowship of the Royal Society, the UK's national academy of sciences! royalsociety.org/people/josep...
Professor Joe Felsenstein FRS | Royal Society Fellow
After initially work on population genetics theory of recombination, of migration, and of speciation, his main focus has been on phylogenetic inference. He s...
royalsociety.org
Congratulations to Leah Anderson on winning People's Choice at the UW Three Minute Thesis competition! grad.uw.edu/current-stud...
2026 UW 3MT Winners
Congratulations to this year’s winners and all of the finalists for sharing their work and representing the breadth and brilliance of graduate research at the University of Washington! First Place |…
grad.uw.edu
Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects www.cell.com/cell/fulltex...
Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects
Variant in situ sequencing (VIS-seq) links genetic variants to cell images, revealing how variants affect molecules, subcellular structures, and cells at scale. Applied to thousands of LMNA and PTEN v...
cell.com
From our Statistical AI Symposium: Bill Noble from @uwgenome.bsky.social on foundation models for chromatin 3D architecture and proteomics mass spectrometry: two very different data types, one elegant framework. 🎥 youtu.be/S6sHSW_bLvY?... #Biostatistics #AIinHealth #FoundationModels
William Noble on Foundation Models
YouTube video by Fred Hutch Biostatistics Program
youtu.be
Congratulations to Hannah Jordt on receiving the UW Distinguished Teaching Award! www.washington.edu/facultystaff...
Announcing the 2026 Awards of Excellence recipients
The UW is delighted to announce the recipients of the 56th annual University of Washington Awards of Excellence! The awards honor outstanding alumni, faculty, staff, students and retirees who...
washington.edu
Excited to see this collaborative work with @oligopain.bsky.social and @keribackus.bsky.social out as a preprint now! Took a ton of work from a great team of scientists @uwgenome.bsky.social and #UCLA The imaging coupled with proteomics open our eyes to new aspects of subcellular organization!
Keri Backus@keribackus.bsky.social · 3mo agoSuper excited to launch POCAxOMAP with @dschweppe.bsky.social and @oligopain.bsky.social and led by Eli Biletch, Conor Herlihy and Lidan Li. If you’ve ever wanted to do proximity labeling on DNA, RNA, or protein without genetic engineering, look no further. www.biorxiv.org/content/10.6...
Congratulations to Jesse Bloom on being elected to the National Academy of Sciences! www.nasonline.org/news/2026-na...
National Academy of Sciences Elects Members and International Members - NAS
WASHINGTON — The National Academy of Sciences announced today the election of 120 members and 25 international members in recognition of their distinguished and continuing achievements in original res...
nasonline.org
Congratulations to Hank Cheng on being named to the Husky 100! www.washington.edu/husky100/#na...
Husky 100
The Husky 100 recognizes 100 UW undergraduate and graduate students who are making the most of their time at the UW.
washington.edu
Congratulations to Kyra Fetter, Kayla Ly, and Mary Krebs on receiving NSF fellowships and to Katrina Peterson and Ivan Woo on receiving honorable mention!
Recurrent mutations drive rapid HIV escape from two broadly neutralizing antibodies in vivo www.pnas.org/doi/10.1073/...
Recurrent mutations drive rapid HIV escape from two broadly neutralizing antibodies in vivo | PNAS
Broadly neutralizing antibodies (bNAbs) show promise for HIV treatment and prevention, but are vulnerable to resistance evolution. Comprehensively ...
pnas.org
Q&A with Dr. Maitreya Dunham: Reflecting on MSS 2026 and Looking Ahead to the Future of Genome Science brotmanbaty.org/news/q-and-a...
Q&A with Dr. Maitreya Dunham: Reflecting on MSS 2026 and Looking Ahead to the Future of Genome Science | Brotman Baty Institute
BBI
brotmanbaty.org
Genetic diversity and regulatory features of human-specific NOTCH2NL duplications pubmed.ncbi.nlm.nih.gov/41916274/
Genetic diversity and regulatory features of human-specific NOTCH2NL duplications - PubMed
NOTCH2NL (NOTCH2-N-terminus-like) genes arose from ape-specific chromosome 1 segmental duplications implicated in human brain cortical expansion, including an incomplete NOTCH2 gene. Genetic character...
pubmed.ncbi.nlm.nih.gov
Congratulations to Iris Jia on being awarded the Charlie Moore Award for outstanding contributions to cystic fibrosis microbiology research!
Congratulations to Katy Loubet-Senear on being awarded a WRF Postdoctoral Fellowship!
NeMO Analytics: a compendium of transcriptomic data for the exploration of neocortical development www.nature.com/articles/s41...
NeMO Analytics: a compendium of transcriptomic data for the exploration of neocortical development - Nature Neuroscience
NeMO Analytics is a compendium of public transcriptomic data focused on the neocortex, enabling biologists without coding expertise to explore hundreds of datasets. Joint decomposition of these data y...
nature.com
Congratulations to Maitreya Dunham and David Baker on being named AAAS Fellows! www.washington.edu/news/2026/03...
Four UW researchers named AAAS Fellows
Four University of Washington researchers have been named AAAS Fellows, according to an announcement by the American Association for the Advancement of Science. They are among 449 newly elected...
washington.edu
Congratulations to Lauren Fields on being selected as a Schmidt Science Fellow! schmidtsciencefellows.org/fellow/laure...
Lauren Fields • Schmidt Science Fellows
Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease with no known cure. As a Schmidt Science Fellow, Lauren will use advanced mass spectrometry and protein analysis of...
schmidtsciencefellows.org
How an MD-PhD Student With Hemophilia Made a Genetic Research Breakthrough rightasrain.uwmedicine.org/well/researc...
An MD-PhD Student Had Hemophilia
How he made a research breakthrough.
rightasrain.uwmedicine.org
Context dependency is essential for predicting intrahost evolution www.nature.com/articles/s41...
Context dependency is essential for predicting intrahost evolution - Nature Ecology & Evolution
The ability to predict rapid evolutionary processes within our bodies would advance both medical science and evolutionary biology. We discuss technologies that move us towards intrahost evolutionary p...
nature.com
Long-read sequencing of families reveals increased germline and postzygotic mutation rates in repetitive DNA www.nature.com/articles/s41...
Long-read sequencing of families reveals increased germline and postzygotic mutation rates in repetitive DNA - Nature Communications
Short‑read sequencing misses many early and repeat‑driven mutations. Here, the authors show that long‑read sequencing in autism families increases detection of germline and postzygotic mutations and r...
nature.com
Using the linear references from the pangenome to discover missing autism variants www.nature.com/articles/s41...
Using the linear references from the pangenome to discover missing autism variants - Nature Communications
Large-effect variants in autism remain elusive. Here, the authors use long-read sequencing to assemble phased genomes for 189 individuals, identifying pathogenic variants in TBL1XR1, MECP2, and SYNGAP...
nature.com
Congratulations to Mike MacCoss on receiving the Distinguished Contribution in Proteomics Award, Bill Noble on receiving the Computational Proteomics Award, and Nathan Basisty on receiving the New Investigator Award from US HUPO! us-hupo.org/Awards
US HUPO - Awards
us-hupo.org
Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast www.micropublication.org/journals/bio...
Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast | microPublication
micropublication.org
Congratulations to Riku Yasutomi on being awarded an NRSA Fellowship!
Congratulations to Andrew Stergachis on being elected to the American Society for Clinical Investigation!
Congratulations to the Stergachis Lab on being awarded an AI for Science fund award from Google! blog.google/company-news...
We’re announcing the 12 recipients of our AI for Science fund
A look at the 12 recipients of the first AI for Science fund.
blog.google
