An ISCRM research team of biologists, engineers, and physicians shows that fibroblasts, often thought of as helpers, may weaken the heart by causing a harmful cycle of stiffening and scarring, and pinpoint a potential fix.

Cole DeForest@coledeforest.bsky.social · 11mo ago

Thanks also to @uwiscrm.bsky.social for nicely highlighting the work! iscrm.uw.edu/helper-or-cu...

The 2025 Stem Cell Mini Symposium is underway with welcomes from Dr. Jen Davis and Dr. Hannele Ruohola-Baker and our first speaker Dr. Aparna Bhaduri!

Taking a breath w new paper announcement. Bioprinted platform for parallelized screening of engineered tissue formulations in mice (1/4). See paper in @cp-cellstemcell.bsky.social here: www.sciencedirect.com/science/arti...

Bioprinted platform for parallelized screening of engineered microtissues in vivo

Human engineered tissues hold great promise for therapeutic tissue regeneration and repair. Yet, development of these technologies often stalls at the…

sciencedirect.com

Researchers in the Reh Lab have produced the clearest evidence yet that AAV-delivered genes can stimulate regeneration in the mammalian retina. @tomreh.bsky.social Marina Pavlou. #retina #regeneration @uwmedicine.bsky.social shorturl.at/qVUKz

Regenerating Retinal Neurons using AAV Vectors / ISCRM

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Terrific piece from @uwcollegeofed.bsky.social on heart research underway here at ISCRM. @pmjboyle.bsky.social www.engr.washington.edu/news/article...

“Ultimately, we hope to help bring an effective therapy to market... that works consistently, that can be broadly applied, and that doesn’t have side effects that would be limiting for millions of people. And we believe this study is another big step in that direction.” @uwmedicine.bsky.social

Freedman Lab Tests an mTOR Inhibitor in PKD Organoids

The researchers found the molecule at the center of the study may be safer at higher doses and therefore more potent against harmful cysts.

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The UW Institute for Stem Cell and Regenerative Medicine (ISCRM) is hiring a full-time Director to lead a collaborative research community in the heart of Seattle working across disciplines to confront the root causes of disease. Learn more and apply: shorturl.at/E2ZIj

Thrilled to share our new “State-of-the-future” review in #ESC Europace: “From bits to bedside: entering the age of digital twins in cardiac electrophysiology” (with apologies to Drs. Zipes, Jalife, & Stevenson!). #EPeeps Link: academic.oup.com/europace/art...

From bits to bedside: entering the age of digital twins in cardiac electrophysiology

Abstract. This State of the Future Review describes and discusses the potential transformative power of digital twins in cardiac electrophysiology. In this

academic.oup.com

Apply by January 17th for the summer 2025 ISCRM Research Experience for Undergraduates. #REU Join a community of scientists at the forefront of regenerative medicine, biology, and engineering. Housing and stipend included! iscrm.uw.edu/trainees/reu/

ICYMI This a.m. David Baker @uwmedicine.bsky.social gave his #NobelPrize Lecture on designing proteins to perform new functions. He forecasts applications in immunotherapies, harvesting sunlight, growing semiconductors, stopping cell damage tied to Alzheimer's & more.

2024 Nobel Prize lectures in chemistry | David Baker, Demis Hassabis and John Jumper

YouTube video by Nobel Prize

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Watch the moments when David Baker @uwmedicine.bsky.social, Demis Hassabis & John Jumper from GoogleDeepMind step up to receive their 2024 #NobelPrize in Chemistry from Swedish King Carl XVI Gustaf during award ceremony Dec. 10 in Stockholm.

Postdocs nationwide in Regenerative Medicine and Engineering: Applications are now being accepted for the 2025 Inclusive Leadership Workshop, taking place May 5-8 in Seattle. No program fees. Travel and accommodations are covered! Priority deadline: January 12 iscrm.uw.edu/inclusive-le...