Thinking about the way of the world, a chat ~25 years ago about a new camp for kids whose parents have cancer, and (soon-to-be) Dr. Jett Crowdis today He shares his motivations in medicine, the link to Camp Kesem, and our science in @harvard.edu Gazette news.harvard.edu/gazette/stor...

The boy had just lost his dad to cancer. Jett Crowdis listened. — Harvard Gazette

Harvard Medical School graduate found his calling in a connection forged while serving as a camp counselor.

news.harvard.edu

In this perspective, we examined the present and future interface of AI & translational cancer research for @cp-cancercell.bsky.social - led by the stellar Dr. Josephine Yates! @danafarber.bsky.social @broadinstitute.org www.sciencedirect.com/science/arti...

New horizons at the interface of artificial intelligence and translational cancer research

Artificial intelligence (AI) is increasingly being utilized in cancer research as a computational strategy for analyzing multiomics datasets. Advances…

sciencedirect.com

Here's our latest - jointly with @rhaq1.bsky.social lab & co-lead by Drs. Schiantarelli, Benamar, Park et al - studying why some tumors stop responding to immunotherapy. This continues to be a tough puzzle to solve, but important for science & patients alike...

Riz Haq@rhaq1.bsky.social · last yr.

Our paper on a new mechanism of resistance to immunotherapy in melanoma is now in print @Cancer_Cell with the @vanallenlab.bsky.social t.co/TCC4brc6yb

While on clinical service recently, I saw many children who were severely ill due to cancer, flu, and other causes. Sadly this move will mean that healthcare access for many children will be lost, as our institutions suffer from the loss of this critical support: grants.nih.gov/grants/guide...

Here's our latest, led by Drs. Riaz Gillani & Ryan Collins - we studied a type of inherited genetic event (structural variants) + risk of developing certain cancers in kids: @danafarber.bsky.social @bostonchildrens.bsky.social @broadinstitute.org @science.org www.science.org/doi/10.1126/...

Rare germline structural variants increase risk for pediatric solid tumors

Pediatric solid tumors are a leading cause of childhood disease mortality. In this work, we examined germline structural variants (SVs) as risk factors for pediatric extracranial solid tumors using ge...

science.org

People sometimes make fun of science that sounds stupid and random. Meanwhile, a study of lizard saliva turned into a peptide medication, which was turned into a diabetes medication, which was turned into a GLP1 weight loss drug, that just became the first therapy every approved for … sleep apnea

The New York Times@nytimes.com · 2y ago

Breaking News: The FDA approved use of the weight loss drug Zepbound for a common form of sleep apnea. It is the first drug authorized to treat the disorder.

Our December knowledge base release is now out! With these two recent FDA approvals, we now have curated over 1,000 records🥳 Explore through our browser at moalmanac.org

Congrats to Larry, Aram et al on latest prostate cancer immunology effort, now out in @natureportfolio.bsky.social - fun collaboration + more to come! @danafarber.bsky.social @ucsfcancer.bsky.social www.nature.com/articles/s41...

Evolution of myeloid-mediated immunotherapy resistance in prostate cancer - Nature

Single-cell profiling of human prostate cancer and studies in mouse models show that macrophages expressing SPP1 mediate immunotherapeutic resistance through adenosine pathway activation and repr...

nature.com

Hello world! We're a paired knowledge base and algorithm for precision cancer medicine, based out of the @vanallenlab.bsky.social within @danafarber.bsky.social in #Boston #MA. You can learn more about us at moalmanac.org!

I wrote about the National Institutes of Health and the various serious and unserious proposals for NIH reform that have been floating around. It is important to understand how this agency actually functions and point criticism at the right problems. A short 🧵:

Distinguishing real from invented problems with the NIH

How does the NIH work and where does it work well?

open.substack.com

Great panel on AI in cancer research at the US Senate, led by Ned Sharpless and organized by Senators Rounds, Schumer, Heinrich, and Young - key engagement & thoughts from the organizers and other Senators, and a chance to share our exciting work at Dana-Farber and beyond!

Here, we built biologically interpretable computer vision models for H&E + mIF images to learn key tumor and immune microenvironmental states in kidney cancer that also inform immunotherapy response - congrats Drs. Nyman, Signoretti, Choueiri et al! www.cell.com/cell-reports...

Rarely are my LA childhood/living experiences helpful around here, but I just talked someone starting a lab in Children's Hospital LA out of "living by the beach and commuting to that part of Sunset" Feels like I did something important, still shook by the potential catastrophe

hello world.