The #CryoEM structures presented in new findings from the Erkan Karakas lab establish a framework for understanding hIP3R-2 regulation across multiple ligand conditions. Read the full publication: www.nature.com/articles/s41... @vubasicsciences.bsky.social

Conformational landscape and ligand-dependent clustering of the human type 2 IP3 receptor - Nature Communications

Here the authors define the conformational landscape of human IP3R-2 and identify a ligand-dependent inter-channel interface that mediates receptor clustering during calcium signalling.

nature.com

Congratulations to the @mutexazjy.bsky.social lab on receiving an NSF Award for their development of an enzymology database as an infrastructure!

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📢 Registration is open for the 2026 VICB Student Research Symposium! 🗓 Sept. 25, 2026 📍 Vanderbilt Student Life Center We're excited to welcome keynote speaker Craig Crews! Register: redcap.vanderbilt.edu/surveys/?s=3... @vubasicsciences.bsky.social

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Check out more CSB faculty contributions to 10 years of @vubasicsciences.bsky.social from SARS-CoV-2 and pandemic-related research to entrepreneurial partnerships with drug discovery and pharmaceutical companies to recognizing faculty with endowed chairs and more! #research #innovation #cryoem

Vanderbilt School of Medicine Basic Sciences@vubasicsciences.bsky.social · 3mo ago

🎉 As our school reaches its 10-year milestone, we’re reflecting on the key decisions that helped define who we are today—from building a collaborative, curiosity-driven #research environment to investing in people, #training, and #innovation. Read more 👉 medschool.vanderbilt.edu/basic-scienc...

Tina Iverson quoted in: What Physical ‘Life Force’ Turns Biology’s Wheels? www.quantamagazine.org/what-physica... via QuantaMagazine 👇

What Physical ‘Life Force’ Turns Biology’s Wheels? | Quanta Magazine

The bacterial flagellar motor is finally understood after 50 years. In its workings, columnist Natalie Wolchover finds the essence of life.

quantamagazine.org

New research highlights how a rare bacterial protein modification could reveal new antibiotic targets. Doug Mitchell and lab members report a rare bacterial protein tweak that could point to new antibiotic targets. Read more: medschool.vanderbilt.edu/basic-scienc... @vubasicsciences.bsky.social

A rare bacterial protein tweak could point to new antibiotic targets

The biochemistry lab of Doug Mitchell discovered the enzyme responsible for a rare chemical modification that doesn't exist in human cells, which can potentially become a new target for developing ant...

medschool.vanderbilt.edu

Very good (if tragic) story from the Washington Post [GIft Link] wapo.st/3OONwh6 1/8

For U.S. medical researchers, shrinking labs and bare budgets are the new reality

The Trump administration has slashed the number of grants from the National Institutes of Health, with far fewer focused on women, cancer and mental health.

wapo.st

The LMB Rising Talent Fellowship is open for new applicants! Aimed at Black heritage scientists, the Fellowship offers a 3-year postdoctoral position beginning Oct-Dec 2026. Visit our website for more info: mrclmb.ac.uk/careers-and-... Please circulate this post to anyone who might be interested!

Congratulations to CSB researcher Stephen Fesik on winning the Marie Maynard Daly Award, the newest award sponsored by The Protein Society, which recognizes groundbreaking research at the interface between protein science and human health. @vubasicsciences.bsky.social

Magnetic Resonance News@nmr900.bsky.social · 4mo ago

The Protein Society @proteinsociety.bsky.social announces its 2026 award recipients. Plenary talks to take place at the Protein Society 40th Anniversary Symposium (July 19 - 22, 2026, Boston, USA) www.proteinsociety.org/protein-soci... #NMRchat #NMR 🧲

If you're at the #CCPEM next week, don't miss the chance for a first look at the new Thermo Scientific™ Glacios™ 3 Cryo-TEM including advances in performance, productivity, and accessibility! 📍 CCPEM Spring Symposium, Nottingham, UK 🕛 Presentation: April 23, 1 PM BST #CryoEM #StructuralBiology

Tomorrow is #GivingDay at @vanderbilt.edu. Your gift to the Dr. Anne Karpay Award in Structural Biology supports a senior graduate student who well-rounded, collaborative, collegial and has performed exceptional research in structural biology. www.givecampus.com/campaigns/57...

Year 3 of Conformational Ensembles Conference! The most compelling questions in structural biology cannot be effectively addressed with a single structure. We have a stellar lineup of people looking at and answering these questions. @fraserlab.com More information: conformationalensembles.github.io

‼️Preprint from the Ivelin Georgiev lab: Prefusion-specific glycoprotein B human antibodies protect against neonatal HSV-2 infection www.biorxiv.org/content/10.6...

Registration is open for Bridging Atoms and Algorithms: A Symposium on AI and Structural Biology! 📅 March 17-18, 2026 🏫 Vanderbilt University in Nashville, TN ℹ️ vanderbilt.edu/csb/caipd-ai... #CryoET #AI #protein #research #CryoEM #Biology @rommieamaro.bsky.social @drgregbowman.bsky.social

🚨Preprint alert! The @stephanieaw.bsky.social lab shows that binding entropy can be quantitatively predicted from crystallographic ensemble models, accounting for both protein conformational entropy and solvent entropy! @vubasicsciences.bsky.social www.biorxiv.org/content/10.6...

We are running the cryo-ET image processing workshop again this year! Come learn everything tomo: STA, segmentation, heterogeneity analysis from @baradlab.com @williamnwan.bsky.social and others! Apply!

U-M Life Sciences Institute@umlifesciences.bsky.social · 7mo ago

While everything feels flash-frozen in Michigan, it's a great time to plan for U-M's 2026 #CryoET Data Processing Workshop! This hands-on workshop will introduce participants to standard image processing packages used to analyze cryo-ET data. Apply by March 20: myumi.ch/lsi-cryo-wor...

Join us as the Spring 2026 VICB seminar series continues on Wednesday, January 28! Dr. Jeremy Smith, Director of the Center for Molecular Biophysics at the Oak Ridge National Laboratory, will present "AI and Modeling in Drug and Vaccine Design" at 12:15 PM in 1220 MRB III.

New #research led by the Georgiev lab shows how #AI and #protein language can speed antibody design to thwart novel viruses! Read more about this study: news.vumc.org/2025/11/04/a...

AI can speed antibody design to thwart novel viruses: study

AI and “protein language” models can speed the design of monoclonal antibodies that prevent or reduce the severity of potentially life-threatening viral infections.

news.vumc.org

New work from the Sanders Lab: Pharmacological tools to modulate ordered membrane domains and order-dependent protein function. @kmstefanski.bsky.social @vubasicsciences.bsky.social @vanderbiltvicb.bsky.social

Communications Chemistry@commschem.nature.com · 7mo ago

Just out: Pharmacological tools to modulate ordered membrane domains and order-dependent protein function

📣 CBT & VICB Trainee Talks Featuring: 🔬 Caro M. Icardi (Iverson Lab, Vanderbilt) 🧪 Hannah Snoke (Lee Lab, St. Jude) 🗓 Jan 15, 2026 ⏰4:30–6:00 PM 📍U1202 MRB III Join us for trainee-led research talks! @vubasicsciences.bsky.social @vanderbilt.edu

Internship opportunity! @jackn.bsky.social and I have opened two Summer Intern positions at Genentech to build structural biology agents. If you are a (pre-PhD) #cryoEM or #Xray structural biologist with strong computational skills & motivation, please apply!

2026 Summer Intern - Agents for Structural Biology in South San Francisco, California, United States of America | Students & Graduates at Genentech

Apply for 2026 Summer Intern - Agents for Structural Biology job with Genentech in South San Francisco, California, United States of America. Students & Graduates at Genentech

careers.gene.com

📢 Planning to apply for an NIH F30, F31, or F32 fellowship? The process can feel overwhelming, but BRET has some helpful resources to guide you through the process and apply by the April 8 deadline! medschool.vanderbilt.edu/career-devel...

Conquer Your Fellowship: A Project Management Tool and Guide for Your NIH Fellowship

Applying for an NIH fellowship can feel overwhelming, but the right guidance makes all the difference. This collection of resources walks you through every stage of the process – from identifying t…

medschool.vanderbilt.edu

Mark your calendars for January 13th when our own Alice-Roza Eruera will give a primer on Building CryoET Training Workflows Using the SBGrid Ecosystem. Register here: buff.ly/AaZQlJL #SBGrid #Structuralbiology #Webinars

Webinars

The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…

buff.ly

Pre-print alert! 🚨 Work from the Chuck Sanders lab and collaborators with first author @kmstefanski.bsky.social. "Pharmacological Tools to Modulate Ordered Membrane Domains and Order-Dependent Protein Function" www.biorxiv.org/content/10.1... #research #biophysics #protein

Pharmacological Tools to Modulate Ordered Membrane Domains and Order-Dependent Protein Function

Ordered membrane nanodomains colloquially known as “lipid rafts” have many proposed cellular functions. However, pharmacological tools to modulate protein affinity for rafts and to manipulate raft for...

biorxiv.org

New preprint! Entropy drives molecular recognition, yet most structure-based drug design ignores it because it is difficult to measure. X-ray crystallography captures ensembles, not single structures. Can we extract thermodynamically meaningful entropy from them? www.biorxiv.org/content/10.1...

Crystallographic Ensembles Reveal the Structural Basis of Binding Entropy in SARS-CoV2 Macrodomain

Structure-based drug design has traditionally focused on optimizing static, enthalpic interactions between ligands and proteins or on displacing binding site solvent molecules to entropically favor bi...

biorxiv.org

Kate Clowes Moster, of the Chuck Sanders lab, is the winner of the 2026 Dr. Anne Karpay Award in Structural Biology! bit.ly/2026-karpay @vubasicsciences.bsky.social @vanderbiltvicb.bsky.social @vandybiomed.bsky.social

@vanderbilt.edu and Ancora Innovations continue their collaboration to advance translational research and health care innovation. VICB recognizes the importance of partnerships that connect discovery with real-world impact. Learn more: bit.ly/47T1ZOP

Vanderbilt’s Ancora Partnership: A collaborative journey toward health care innovation

Since the inception of the Ancora Innovations partnership in 2018, Vanderbilt and Deerfield Management have enjoyed a robust collaboration. Deerfield’s commitment includes significant support for adva...

bit.ly

🧬 🪦 Dean emeritus Larry Marnett, Mike Goodman (staff scientist in the Sanders lab), and senior advisor to the dean Chuck Sanders paid their annual visit to the grave of Oswald Avery, the scientist “best known for his discovery that DNA serves as genetic material. profiles.nlm.nih.gov/spotlight/cc