Importance of antibody validation in detecting cell cycle regulatory protein p16 INK4A by immunohistochemistry on pancreas tissue

p16INK4A is a cyclin-dependent kinase inhibitor that plays important roles in pancreatic islet beta-cell maturation, function, and senescence. As staining pattern consistency and reproducibility ha...

tandfonline.com

Inflammation Investigator

UM alum and researcher Samantha Pauls studies immune cells and their role in chronic inflammation.

umtoday.ca

Socioeconomic differences in the prevalence, treatment and control of major cardiometabolic risk factors by sex: a cross-sectional study of the UK Biobank

Introduction Social deprivation is related to cardiovascular risk, but the prevalence of cardiometabolic risk factors by deprivation and sex is less explored. We addressed this in a large UK cohort.Me...

bmjpublichealth.bmj.com

Maternal butyrate administration ameliorates fetal fatty liver and maternal metabolic alterations related to maternal obesity

Obesity negatively impacts maternal and fetal metabolism, leading to the programming of metabolic disturbances in the offspring. We have previously re…

sciencedirect.com

Mommy Issues: How Maternal Diet Shapes Offspring Mitochondrial Physiology

Lay Summary. Poor metabolic health and obesity during pregnancy are associated with a greater risk of childhood obesity and early development of metabolic

academic.oup.com

Intergenerational obesity prevention through nanogenomic targeting of gestational diabetes-induced epigenetic programming

Gestational diabetes mellitus (GDM) represents one of the most consequential metabolic complications of pregnancy, affecting an estimated 14–17% of al…

sciencedirect.com

Dietary Interventions Targeting Maternal Obesity: Intergenerational Effects, Mechanisms, and Translational Insights - Current Nutrition Reports

Purpose of Review Maternal obesity is a major public health challenge that elevates pregnancy risks and predisposes offspring to lifelong metabolic disorders. Nutrition, as a modifiable determinant of...

link.springer.com

Addressing bioenergetic deficits and restoring mitochondrial health in transplanted islets using mesenchymal stem cells

Abstract. During the process of islet transplantation, islets undergo isolation and are then introduced into a new microenvironment where they need to adap

academic.oup.com

Next Gen - DREAM - Diabetes Research Envisioned & Accomplished in Manitoba

Back to Clinical Research StudiesnnDiabetes ResearchnnClinical Birth Cohort StudynnOur ResearchnnPatients and FamiliesnnInformation for

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Skeletal muscle mitochondrial bioenergetics in pregnancy: a comparison of in vivo and in vitro outcomes

AbstractPurpose. Exercise-mediated adaptations to mitochondria are well established in nongravid populations; however, the extent to which these adaptation

academic.oup.com

The Core Circadian Clock Factor, Bmal1, Transduces Sex-specific Differences in Both Rhythmic and Nonrhythmic Gene Expression in the Mouse Heart | Function | American Physiological Society

Abstract It has been well established that cardiovascular diseases exhibit significant differences between sexes in both preclinical models and humans. In addition, there is growing recognition that d...

journals.physiology.org

Deep single-cell decoding of human pancreatic islets reveals T2D β-cell gene expression defects - The EMBO Journal

Pancreatic islets maintain glucose homeostasis through coordinated action of endocrine and affiliate cell types and are central to type 2 diabetes (T2D) genetics and pathophysiology. Our understanding...

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Detection of young-onset type 2 diabetes using deep learning across primary and secondary care: a nationwide, retrospective cohort study

This study highlights the potential for using deep learning methods on longitudinal health data from both primary and secondary care to develop low-cost predictive tools for screening of young-onset t...

thelancet.com

Frontiers | Functional validation of a non-canonical HNF1B splice-site variant in MODY5

BackgroundMutations in the HNF1B gene can cause developmental and functional abnormalities in multiple organs such as the pancreas, kidneys, and liver. The p...

frontiersin.org

Frontiers | Maternal obesity alters adipogenic potential and mitochondrial maximal respiration in infant mesenchymal stem cells

ObjectiveTo assess the adipogenic potential and mitochondrial bioenergetics of umbilical cord mesenchymal stem cells (UC-MSCs) derived from infants born to m...

frontiersin.org