Better late than never! The Rendo Lab website is officially up and running 🧠 🧬 Read about our ongoing research and the wonderful team that makes it happen! rendolab.org
Rendo Lab
rendolab.org
Veronica Rendo
@vrendo.bsky.social
Group Leader, Uppsala University 🇸🇪 | Studying brain tumor evolution and treatment resistance
Excited to get the #EMBOChromoploidy meeting started! 3 days of fantastic science and fun in beautiful Stresa are beginning now! meetings.embo.org/event/25-ane...
Chromosome Segregation and Aneuploidy
Aneuploidy is a hallmark of cancer and developmental disorders such as Down syndrome. Understanding how cells accomplish faithful chromosome segregation and how chromosomal instability (CIN) impacts …
meetings.embo.org
📣 Online now! Our study shows how recurrent focal deletions constitute a mechanism by which cancer cells can dampen toxicity due to gene amplification. www.cell.com/cell-genomic... 🧵👇:
Recurrent breakpoints in the BRD4 locus reduce toxicity associated with gene amplification
Wala et al. identify recurrent focal BRD4 deletions in tumors harboring larger amplifications, suggesting that these deletions may serve to limit toxic BRD4 overexpression. A CRISPR-Cas9 cell line mod...
cell.com
Today we celebrated my official Group Leader appointment and paper publications with bubbles and prinsesstårta, the Swedish way! 🍰🥂🍾 Skål!
So excited to see this paper out! An example of how window of opportunity trials can help dissect the mechanisms of response and resistance associated with targeted therapies in glioblastoma 🧠 www.science.org/doi/10.1126/... Thanks to the patients and scientific team who made this study possible.
A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma
In patients with glioblastoma, navtemadlin resistance is not mediated by TP53-inactivating mutations, and combination with TMZ may improve efficacy.
science.org
So excited to see our paper describing the class of ARGOS genes in cancer out in @naturecomms.bsky.social! 🤩 www.nature.com/articles/s41... A giant effort led with @ms01.bsky.social and executed under the mentorship of @bendavidlab.bsky.social @rameenberoukhim.bsky.social @foijer-lab.bsky.social 🧵👇:
A compendium of Amplification-Related Gain Of Sensitivity genes in human cancer - Nature Communications
In cancer, the impact on cellular fitness of copy-number gains affecting collaterally-amplified genes remains poorly understood compared to oncogenes. Here, the authors integrate genomic data from tum...
nature.com