Congrats to IMP faculty member Morgan Huse @huselab.bsky.social and his team on their latest study published in @cp-immunity.bsky.social on the adaptation of metastatic tumors to their tissue environment, allowing for mechanosurveillance by cytotoxic lymphocytes. www.cell.com/immunity/ful...

Environmentally induced cell stiffening shapes metastatic site selection by tuning the immune vulnerability of cancer cells

Adherent cells mimic the mechanical properties of their surroundings, becoming stiffer in more rigid environments and softer in more compliant ones. Elbanna et al. find that this environmentally induc...

cell.com

Thank you to @mskcancercenter.bsky.social for highlighting recent published work from @tanmanamitra.bsky.social! www.mskcc.org/news/new-str...

Please repost! #microsky🦠 The Glickman Lab at MSK is recruiting! Projects in Mtb pathogenesis, basic biology of mycobacteria, and mycobacterial cancer therapies. See our publications here: tinyurl.com/3f386f4x Send CV and cover letter to: glickmanmycolab@gmail.com

(1/2) Scientists from MSK and @weillcornell.bsky.social found that a small subset of T cells, called stem T cells, are responsible for making new T cells and continuously replenishing them in chronic disease.

📣Seeking highly motivated and creative Postdoctoral Fellow Build on our recent Nature 2026 story on caspase-5. Exciting projects linking innate immunity, regeneration, IBD, & cancer. DM or email: blanderadmin@med.cornell.edu. CV, cover letter, 3 refs. #Postdoc #Immunology #IBD #CancerBiology #Hiring

Congratulations to IMP faculty Dr Tobias Hohl @fungalspore.bsky.social and his team on their latest study published in @cp-cellhostmicrobe.bsky.social on fungal-host interactions where host valeric acid inhibits candida growth via intracellular acidification. www.cell.com/cell-host-mi...

Intracellular acidification by microbiota-derived valeric acid facilitates trans-kingdom ecology limiting Candida parapsilosis colonization

By screening Lachnospiraceae supernatants using SHAP analysis, Yasuma-Mitobe et al. identify bacteria-derived valeric acid (VA) as an inhibitor of C. parapsilosis growth. VA levels inversely correlate...

cell.com

Check out this comprehensive review on B cell class switch recombination for diversifying antibody function from IMP faculty member Dr Jayanta Chaudhuri published in Annual Reviews Immunology @annualreviews.bsky.social www.annualreviews.org/content/jour...

The Molecular Logic of Immunoglobulin Heavy Chain Class Switch Recombination

Class switch recombination (CSR) enables B cells to diversify antibody effector functions while preserving antigen specificity. This process involves activation-induced cytidine deaminase (AID)–mediat...

annualreviews.org

Congratulations to IMP faculty member Dr Theresa Lu @theresalulab.bsky.social and her team on their latest study in @sciimmunology.bsky.social on langerhans cell-lymphatic crosstalk in early life. www.science.org/doi/10.1126/...

Langerhans cell control of early-life dermal lymphatic development shapes adult immunity

Langerhans cells mediate dermal lymphatic growth in early life, which affects lymph node T cell responses in adulthood.

science.org

Congratulations to IMP student Ian Mantel @ianmunology.bsky.social in the lab of Dr Laura Donlin on their study highlighting a specific macrophage subset that remodels the arthritic niche during disease progression. @science.org www.science.org/doi/10.1126/...

SPP1hi macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium

SPP1hi macrophages in synovial fibrin deposits promote tissue hyperplasia in the joints of individuals with rheumatoid arthritis.

science.org

Online now: Transcription factor BHLHE40 expression in group 3 innate lymphoid cells and RORγt⁺ antigen-presenting cells coordinates intestinal immunity

Transcription factor BHLHE40 expression in group 3 innate lymphoid cells and RORγt⁺ antigen-presenting cells coordinates intestinal immunity

The ability to maintain tolerance at mucosal barrier surfaces is critical for immune homeostasis. Yang et al. identify Bhlhe40 as a central regulator linking innate and adaptive intestinal immunity. By coordinating ILC3 effector responses with RORγt⁺ antigen-presenting cells, Bhlhe40 integrates inflammatory and microbial signals to balance tissue protection with tolerance, providing insight into mechanisms relevant to inflammatory bowel disease.

dlvr.it

Hyunu Kim et al. @josephsunlab.bsky.social show that, in activated #NKcells, IL-12 remodels the RNA polymerase II landscape within minutes, increasing IFN-γ promoter occupancy and pausing in a STAT4- and DDX5-dependent manner. rupress.org/jem/article/...

Congratulations to IMP faculty Dr Joseph Sun @josephsunlab.bsky.social and his team on their latest study in @jem.org demonstrating a role for RNA pol II redistribution during antiviral NK cell activation dependent on the transcription factor STAT4 and RNA helicase DDX5. rupress.org/jem/article/...

Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells

Rapid production of the effector cytokine IFN-γ by natural killer (NK) cells is critical for host defense against viral infection. In activated NK cells, I

rupress.org

Spotlight on new findings from the IMP program!! news.weill.cornell.edu/news/2026/07...

Congratulations to IMP student Svetlana Miakicheva in the lab of Dr Andrea Schietinger on publishing this paper highlighting the transcription factor LEF in promoting T cell stemness in settings of chronic inflammation. www.cell.com/cell/abstrac...

LEF1 and niche factors determine T cell stemness across chronic diseases

In settings of persistent antigen, such as autoimmunity and chronic infection, stem-like CD8 T cells sustain antigen-specific immune responses. Here, LEF1 and niche-derived factors are identified as e...

cell.com

Congratulations to IMP student Tanmana Mitra in the lab of @santoshvardhana.bsky.social for successfully defending her thesis! Stay tuned, as Tanmana’s work on metabolic regulation of T cell exhaustion will soon be published. Best wishes to Dr. Mitra as she begin her postdoc at U Chicago this fall.

Congratulations to IMP faculty member Randy Longman and his team on their latest study defining a key transcription factor BHLHE40 in controlling the ability of ILC3 and RORgt+ APC in driving the induction of peripheral Tregs and supporting mucosal immunity. www.cell.com/immunity/abs...

Transcription factor BHLHE40 expression in group 3 innate lymphoid cells and RORγt⁺ antigen-presenting cells coordinates intestinal immunity

The ability to maintain tolerance at mucosal barrier surfaces is critical for immune homeostasis. Yang et al. identify Bhlhe40 as a central regulator linking innate and adaptive intestinal immunity. B...

cell.com

A huge congratulations to our newest PhD, Dr. @brookefiedler.bsky.social of the Sonnenberg Lab! 🎓🥳she successfully defended her thesis! Congratulations from the IMP Program and best wishes for all that's ahead!🧫🎉

and here's more from the @wcm-imp.bsky.social year end party :) including @josephsunlab.bsky.social @theresalulab.bsky.social and all of us!

Been a long time since we posted :) But end-of-year @wcm-imp.bsky.social BBQ is a great excuse to resume! here's some highlights that prominently feature Will Stein who is leaving us for Med School and the HSS labs - @theresalulab.bsky.social Ivashkiv lab, Niewold lab and us!

From first experiments to final defenses, our IMP graduates have spent years asking big questions, and supporting one another along the way. Today we celebrate their hard work, achievements, and this well-earned milestone. Congratulations, Class of 2026! 🎓👏

It’s Convocation and Commencement week at Weill Cornell Graduate School! We’ll be sharing highlights of our IMP grads and faculty! 🧑‍🎓👩‍🎓🎓🧬🔬🧫

Shoutout to @anaccodo.bsky.social for being recognized as a Pioneers in Diversity awardee at Weill Cornell Medicine! Proud to see our students leading with impact and purpose. news.weill.cornell.edu/news/2026/04...

Shoutout to @magarianblander.bsky.social and her lab on their recent paper out in @nature.com Another example of the incredible science coming from our faculty!

J Magarian Blander@magarianblander.bsky.social · 3mo ago

Extra happy realizing that our new CASP5 paper is accompanied by a News & Views piece that so thoughtfully reflects on its meaning. A huge thank you to Judy Lieberman and Ayijiang Yisimayi for writing such an insightful commentary. www.nature.com/articles/d41...

Open Box Science Immunology Shaping Macrophages: Microplastics and Developmental Origin 🔹Ana Codo @anaccodo.sky.social @WCM_IMP @wcm-imp.bsky.social @mskcancercenter.bsky.social 📅 Thrusday, April 30 ⏰ 2 pm ET 💻 us02web.zoom.us/j/82008313506

Big news! 🎉 Weill Cornell Graduate School congratulates the graduate students awarded the 2026 NIH F31 Predoctoral Fellowship. Shoutout to our very own Shane Vedova of the Brad Jones lab for this achievement! gradschool.weill.cornell.edu/2026-nih-par...

IMP has been BUSY these past few weeks! Last week, the Weill Cornell Graduate School hosted its 45th annual Vincent du Vigneaud Symposium, highlighting some of our brightest trainees. Congrats to Esther Lee (IMP) and Aliya Holland (Pharm) of the @huselab.bsky.social on earning Top Poster Awards! 🔬🎓

🎓 Congrats Dr. Logan Fisher of the Brown Lab on defending your thesis on "Uncovering Dendritic Cell Heterogeneity and Function" proving even dendritic cells can’t stay mysterious forever. Thesis defended, next stop postdoc life 🧬 @chrysothemisbrown.bsky.social

Another shoutout to the IMP post-docs and faculty on their presentations at the AAI conference as well!

Shout out to our IMP students and faculty who represented our program at the AAI Conference in Boston last week! 👏✨ Sharing a few highlights from the conference! 📸

Excited to share that our lab’s first preprint is now available! This work reflects a huge effort from graduate student Abeera Mehmood and coauthors! If you are interested in what B cells make all antibodies against norovirus take a look! www.biorxiv.org/content/10.6...