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Wilfling Lab

@wilflinglab.bsky.social

Investigating mechanisms of eukaryotic cellular quality control with a focus on autophagy @MPIbp via #cryoET, #teamtomo, #cellbiology and #massspectrometry

24 Posts612 Follower497 Folgt
Felix Kraus@sauerkrausi.bsky.social · 4w ago

Happy to share our neuronal lysosomal storage disorder toolkit has been published in PNAS! 📚Paper: www.pnas.org/doi/10.1073/...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

pnas.org

Felix Kraus@sauerkrausi.bsky.social · 4mo ago

Updated preprint 🧵 We mapped how loss of 23 LSD genes reshapes neuronal proteomes in cortical (iN) and dopaminergic (iDA) neurons New in v2: We added a computational PPI pipeline assessing KO-dependent vulnerability at the interaction and complex level.

Felix Kraus@sauerkrausi.bsky.social · 4mo ago

Updated preprint 🧵 We mapped how loss of 23 LSD genes reshapes neuronal proteomes in cortical (iN) and dopaminergic (iDA) neurons New in v2: We added a computational PPI pipeline assessing KO-dependent vulnerability at the interaction and complex level.

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Claudine Kraft's Lab @kraftlabfr.bsky.social · last yr.

🔄 Repost because the previous link was broken! To degrade or not to degrade! We put together an Autophagic Punctum with @wilflinglab.bsky.social on our latest paper, take a look if you're interested! 🔗 www.tandfonline.com/doi/full/10....

To degrade or not to degrade: how phase separation modulates selective autophagy

Selective macroautophagy/autophagy relies on newly formed double-membrane compartments, known as phagophores, to sequester and recycle diverse cellular components, including organelles, biomolecula...

tandfonline.com

Claudine Kraft's Lab @kraftlabfr.bsky.social · 2y ago

🚨 Paper Alert! We’re starting off the year with our latest publication in @naturecellbiology.bsky.social on the role of phase separation in selective autophagy initiation! This work was a close and exciting collaboration with @wilflinglab.bsky.social 🔗 nature.com/articles/s41... Here's a thread👇

Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy - Nature Cell Biology

Licheva, Pflaum, Babic, Mancilla et al. show that low-affinity cargo–receptor interactions promote autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub ...

nature.com

Wilfling Lab@wilflinglab.bsky.social · 2y ago

Check out our latest publication in @naturecellbiology.bsky.social on the role of phase separation in selective autophagy initiation! This was done in a fantastic collaboration with ‪@kraftlabfr.bsky.social‬ www.nature.com/articles/s41... Short teaser below 👇👇👇

Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy - Nature Cell Biology

Licheva, Pflaum, Babic, Mancilla et al. show that low-affinity cargo–receptor interactions promote autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub ...

nature.com

Wilfling Lab@wilflinglab.bsky.social · 2y ago

Great opportunity! We are looking for a PhD student to work on novel sample preparation methods for cryo-electron tomography.

IMPRS on Cellular Biophysics@imprs-cbp.bsky.social · 2y ago

Are you already on track to apply to our #gradschool? 👣 This is a little map of our application process! We hope, you don´t get lost on the way 😊 If you want to start your #phdjourney with IMPRS-CBP #applynow Don’t miss the chance and apply by February 7th. 👉 imprs-cbp.mpg.de 👈 #imprs_cbp

Map of application process to IMPRS for Cellular Biophysics. Applications are open until February 7th, 2025. Interviews will take place from April 7th to 11th. The program will start on September 15th, 2025.