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Will Shaw

@willshaw.bsky.social

Postdoc in Mo Khalil’s lab at Boston University • synthetic biology • genome engineering • plants • yeast

17 Posts319 Follower198 Folgt
Mo Khalil@mokhalil.bsky.social · 3w ago

🌱🚨 Very proud and excited to share our PREPRINT, unveiling an advance for plant science, biotech, & synthetic biology in the first (of many) Khalil <> Gehring collaborations! www.biorxiv.org/content/10.6...

Rational design of T-DNA vectors enables predictable, single-copy integration in Arabidopsis thaliana

Agrobacterium -mediated transformation is the dominant method for plant transgenesis, yet it frequently produces multi-copy, structurally complex T-DNA insertions associated with transgene silencing, ...

biorxiv.org

Will Shaw@willshaw.bsky.social · 2mo ago

New preprint out 🌱 We present a new T-DNA vector system for Arabidopsis that supports clean, genomically mapped, single-copy T-DNA insertion with predictable cell-type/conditional gene expression. @mokhalil.bsky.social + Gehring labs biorxiv.org/content/10.6... 🧵1/16

Rational design of T-DNA vectors enables predictable, single-copy integration in Arabidopsis thaliana

Agrobacterium-mediated transformation is the dominant method for plant transgenesis, yet it frequently produces multi-copy, structurally complex T-DNA insertions associated with transgene silencing, u...

biorxiv.org

Tom Ellis@proftomellis.bsky.social · last yr.

Online now @ Cell is the yeast multicellular engineering paper from Fankang Meng - the fruits of his productive PhD in our group. He developed modular synthetic biology tools to bring multicellular behaviours to yeast - specific adhesion, juxtacrine signalling and more. www.cell.com/cell/fulltex...

Engineering yeast multicellular behaviors via synthetic adhesion and contact signaling

By designing synthetic toolkits for contact-based signaling (MARS) and cell-cell adhesion (SATURN), we program yeast to form multicellular structures and perform complex tasks, like building logic cir...

cell.com

Will Shaw@willshaw.bsky.social · last yr.

Thrilled to share that I will be moving back to the UK later in the year to start my next chapter as a Career Development Fellow at the Earlham Institute! 🌱🧬

Earlham Institute@earlhaminst.bsky.social · last yr.

💬 “Being in Norwich, at the heart of UK #plantsciences, will allow me to build strong collaborations and contribute to the development of resilient, sustainable #crops capable of meeting the challenges of a growing population and a changing climate.” - @willshaw.bsky.social buff.ly/FQEQcIP #synbio

Satyaki PRV@satyakirv.bsky.social · 2y ago

Do you want an EMS-like drug that you can easily use in your lab or your garden shed to generate structural variation in your favorite plant? We show here that the topo2 inhibitor & common chemotherapy drug etoposide works really well to generate structural variation .

A simple method to efficiently generate structural variation in plants

Phenotypic variation is essential for the selection of new traits of interest. Structural variants, consisting of deletions, duplications, inversions, and translocations, have greater potential for ph...

biorxiv.org