Pleased to share our latest paper, out today in @natimmunol.nature.com www.nature.com/articles/s41...

Airway immune signatures of protection and disease progression in recent human tuberculosis household contacts - Nature Immunology

The local immune factors dictating whether individuals who have been infected with Mycobacterium tuberculosis remain healthy or progress to active tuberculosis (TB) have not been defined. Here O’Garra...

nature.com

A nice discussion here of our work on the early immune response in M. tuberculosis infection and the great recent paper from @bengern.bsky.social et al

Journal of Experimental Medicine@jem.org · 11mo ago

First impressions count in #TB. Andrea Cooper @uniofleicester.bsky.social discusses studies by @wjbranchett.bsky.social et al. (rupress.org/jem/article/...) and @bengern.bsky.social et al. (rupress.org/jem/article/...), in Insights: rupress.org/jem/article/...

Stetsenko et al. show that TCR clonotypes from individuals latently infected w/ M. #tuberculosis demonstrate dominant but not exclusive recognition of infected #macrophages, specificity for type VII secretion system substrates, & expression of canonical effector programs rupress.org/jem/article/...

Pleased to see this out now in @jem.org 🔬 We characterise the early immune response during M. tuberculosis infection in mouse models and demonstrate a detrimental role for type I interferon activated neutrophils in TB lesions. Thanks to all involved @crick.ac.uk and i3S, Porto.

Journal of Experimental Medicine@jem.org · last yr.

William J. Branchett, Anne O’Garra @crick.ac.uk et al. reveal that type I signaling early during M. #tuberculosis infection favors #neutrophil swarming and limits CD4+ T cell–#macrophage interactions in #TB lesions, impeding TB disease control. rupress.org/jem/article/...

Great day out talking all things infection at #LINEsymposium2025 today. Thanks for having me!

London Infection Network for/by ECRs (LINE)@londoninfectionecr.bsky.social · last yr.

We are heading straight into session 3 of our selected talks. @wjbranchett.bsky.social @crick.ac.uk is up first, focussing on M. tuberculosis infection. #LINEsymposium2025

Looking forward to presenting our work on early mechanisms of TB susceptibility at the @londoninfectionecr.bsky.social Symposium in June 🦠🔬

London Infection Network for/by ECRs (LINE)@londoninfectionecr.bsky.social · last yr.

We can see our ECR-focused LINE symposium already on the horizon (9th of June) @crick.ac.uk. shorturl.at/MyWNl 🥳 You can submit your abstracts (talk or poster) until the EXTENDED DEADLINE on the 12th of May here: shorturl.at/7KuXL Free registration shorturl.at/wLyWY We're excited to see you there!