Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...

Have you ever wondered about nonlinearity in bivariate genetic associations? Or wondered whether global estimators like genetic correlations tell the full story about the relationship between two phenotypes, then check out @michelnivard.bsky.social thread on some work we’ve been doing to model this.

Michel Nivard@michelnivard.bsky.social · last yr.

🚨NEW PAPER! Together with Wuno Akingbuwa (@wonuola.bsky.social) we developed a way to estimate non-linear genetic correlations. It didnt sit well with us that known non-linear relations (e.g. BMI and MDD with a famous U shaped ) are poorly captured in statistical genetics. 🧵

🚨NEW PAPER! Together with Wuno Akingbuwa (@wonuola.bsky.social) we developed a way to estimate non-linear genetic correlations. It didnt sit well with us that known non-linear relations (e.g. BMI and MDD with a famous U shaped ) are poorly captured in statistical genetics. 🧵

Outreach in psychiatric genetics - What is it? Why do we need it? How can we do it well? Join me, Niamh Ryan, and Cindy Bulik this Friday (6th) at 10am EST / 4pm CET / 3pm UTC where we'll discuss all of this for the PGC (@pgcgenetics.bsky.social) World Wide Lab 🌎 🔗 us02web.zoom.us/j/88690327502