Woodson Lab
@woodsonlab.bsky.social
RNA detectives on a mission to catch RNA in the act of folding & uncover how proteins helped. Run by graduate students / postdocs. Dr. Sarah Woodson’s Lab at Johns Hopkins University.
New from @woodsonlab.bsky.social @tjiandarzacq.bsky.social and @nilswalterlab.bsky.social www.nature.com/articles/s41...
Exchange dynamics and kinetic control of gene regulation complexes - Nature Reviews Molecular Cell Biology
Recent evidence reveals how gene expression complexes form transient assemblies that continually exchange their subunits under kinetic control. This Perspective proposes that these dynamics form the b...
nature.com
Congratulations to historian Richard Kagan, neuroscientist Ulrich Mueller, political scientist Vesla Weaver, and biophysicist Sarah Woodson on being elected to the American Academy of Arts and Sciences. hub.jhu.edu/2026/04/30/a...
Four from Johns Hopkins elected to the American Academy of Arts and Sciences
Richard Kagan, Ulrich Mueller, Vesla Weaver, and Sarah Woodson among 252 individuals recognized for excellence in their fields
hub.jhu.edu
Our new paper is out! Using 19F NMR, we show that Hfq rewires the conformational dynamics of a model sRNA in a site-specific manner. Uridines at the rim undergo faster exchange (~100 μs) than those in the proximal pore (~300 μs). Congrats Elise! 🎉🎉 www.sciencedirect.com/science/arti...
19F NMR Strategy for Probing Site-specific RNA Dynamics in Large RNA-protein Complexes: Application to the Hfq RNA Chaperone
Nuclear magnetic resonance (NMR) spectroscopy is uniquely suited to probing motions on the microsecond to millisecond timescales that underlie RNA rec…
sciencedirect.com
🎉 We’re excited to officially kick off the ERC Synergy project, snoOPERA, with Anthony Henras, Brigitte Pertschy, and Roland Beckmann! 🎉 Bringing together labs across 3 European countries and the US, we aim to uncover hidden functions of snoRNPs in ribosome assembly. Go team! tinyurl.com/2e5r57b5
Congratulations to Anthony Henras, winner of the ERC Synergy 2025 grant!
Parmi les 66 projets sélectionnés par le Conseil européen de la recherche, Anthony Henras et l’équipe EukaRiBio (MCD-CBI) sont lauréat d’un des 13 projets du
tinyurl.com
🚨New paper alert! Using single molecule TIRF microscopy, we show that Nop1 destabilizes RNA structure via transient, nonspecific interactions — until specific assembly of native ribosomal complexes takes over. Congrats, Wilson! 🎉 academic.oup.com/nar/article/...
Fibrillarin/Nop1 perturbs RNA folding and assembly independently of liquid–liquid phase separation
Abstract. The liquid–liquid phase-separated environment of the eukaryotic nucleolus is proposed to benefit ribosome assembly by chaperoning rRNA folding an
academic.oup.com
Our recent #singlemolecule study on RNase J decay is out! Congrats, Yuan! 🎉🎉 www.sciencedirect.com/science/arti...
Metastable Folding of Bacillus subtilis glmS Ribozyme Modulates Turnover by RNase J1
Rapid turnover of glmS mRNA in Bacillus subtilis by 5′–3′ exoribonuclease RNase J is essential for feedback regulation of glucosamine-6-phosphate (Glc…
sciencedirect.com
This bunch of RNA lovers knows how to unwind! Enjoying A-U-tumn and apple picking 🍎🍏
Congratulations to Elise White @elisew00.bsky.social on winning a poster prize at the Regulating with RNA in Bacteria and Archaea meeting in Strasbourg! 🎉🎉
Our new paper is out in PNAS! We show that competition for binding to the Hfq matchmaker disfavors mismatched sRNA-mRNA combinations while allowing matched sRNA-mRNAs to form stable pairs. Kudos to Jorjethe Roca and Yi-Lan Chen for their fantastic work on this problem! doi.org/10.1073/pnas...
Competition for Hfq drives kinetic selection of mRNA targets by Escherichia coli small noncoding RNAs | PNAS
Small noncoding RNAs (sRNAs) regulate gene expression in Escherichia coli bacteria in response to diverse stimuli in the environment and the host. ...
doi.org
Congratulations to Wilson on your NAR #Breakthrough paper!
Nucleic Acids Research@narjournal.bsky.social · last yr.New #Breakthrough article from @Woodsonlab.bsky.social shows how the E.coli RNA DEAD-box helicase unfolds unstable RNAs to fuel ribosomal RNA remodeling and the search for the native, protein binding structure! #Ribosome #RNA #Helicase 👉 Full article: https://doi.org/10.1093/nar/gkaf104
Hello #RNA afficionados! We’re excited to join the science community on Bluesky!
