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Aaron and the Hoskins Lab at UW Madison

@uwmadisonrna.bsky.social

Interested in science, RNA, splicing, and single molecule biophysics.

800 Posts626 Follower407 Folgt
Aaron and the Hoskins Lab at UW Madison@uwmadisonrna.bsky.social · 2d ago

Exciting paper from David Bentley's lab and coworkers on the role of U1 and RNAP II in exon definition. Also, happy to have contributed to it in a small way! www.biorxiv.org/content/10.6...

Widespread exon definition is promoted by the U1 snRNP 70K subunit and requires sites of contact with RNA Polymerase II

Much pre-mRNA splicing initiates co-transcriptionally, but its mechanism is unclear. We investigated this process by degron depletion of the U1-70K subunit of U1 snRNP that contacts transcribing RNA p...

biorxiv.org

Cell - a Cell Press journal@cp-cell.bsky.social · 4d ago

Now online! Structural basis of a SWI/SNF-associated transcription pre-initiation complex

Structural basis of a SWI/SNF-associated transcription pre-initiation complex

Cryo-EM and genetic analyses reveal that the SWI/SNF chromatin remodeler is an integral component of the transcription pre-initiation complex. The structures demonstrate how SWI/SNF facilitates transcription initiation through stabilization of PIC organization and concerted remodeling of the +1 nucleosome.

dlvr.it

Markus Hafner@markushafnerrna.bsky.social · 2w ago

Become our colleague at NIAMS! We’re looking for a new tenure-track investigator. NIH is an exceptional place to start a lab: fantastic colleagues across every discipline, outstanding core facilities, stable funding, and the freedom to develop a research program limited only by your imagination.

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Alex Zalben@azalben.bsky.social · 3w ago

Here's the official announcement of Parton's passing from her reps, along with the request that in lieu of flowers, the family asks for donations to be made to Dolly Parton’s Imagination Library at www.imaginationlibrary.com

NASHVILLE, TN (August 25, 2026) – Global icon and humanitarian, Dolly Parton, known to the world as a beloved singer, songwriter, philanthropist, actress, playwright, and author died peacefully today in Nashville, Tennessee. She was 80 years old. Dolly is preceded in death by her beloved husband of 59 years Carl Thomas Dean (1942 – 2025), her mother Avie Lee Caroline Owens (1923 – 2003), and father, Robert Lee Parton, Sr. (1921 – 2000). A rhinestone life that shone bright enough for the world to see, Dolly will forever stand as an inspiration not only through her timeless music and prolific songwriting, but also her wit, warmth, and kindness that made us all feel like family. Dolly Parton’s legacy is one of love, compassion, and resilience. With a seven-decade career, she inspired multiple generations of artists and fans with her music and an unwavering commitment to making the world a better place. Her songs will continue to resonate with people of all ages, and her philanthropic work will have a lasting impact. At Dolly’s request, a small, private service will be held for immediate family. Dolly’s fans and friends from around the world are encouraged to pay tribute to Dolly on social media by tagging @DollyParton or by leaving a message at www.dollyparton.com. In lieu of flowers the family asks for donations to be made to Dolly Parton’s Imagination Library at www.imaginationlibrary.com.
Alex Zalben@azalben.bsky.social · 3w ago

Dolly Parton, among a thousand other amazing things she did in her life, gifted over 330 million books to kids through her Imagination Library program. Her passing is a tremendous loss to the world, but you can support the program today to keep it going imaginationlibrary.com

Job Dekker@jobdekker.bsky.social · 3w ago

How do nuclear compartments form inside cell nuclei? We show RNA glues certain loci together to form a nuclear compartment. This involves special GC-rich regions of highly expressed genes that also associate with nuclear speckles, but interactions between these loci are independent of speckles!

bioRxiv Genomics@biorxiv-genomic.bsky.social · 3w ago

Formation of an RNA-mediated nuclear compartment https://www.biorxiv.org/content/10.64898/2026.08.20.746005v1

Aaron and the Hoskins Lab at UW Madison@uwmadisonrna.bsky.social · 3w ago

Now online! Happy to have been part of this remarkable study on TDP-43 from the Butcher Lab @uwbiochem.bsky.social www.nature.com/articles/s41...

TDP-43 controls RNA structure through high affinity lattice interactions - Nature Communications

TDP-43 is an essential RNA-binding protein. Here, the authors show how it binds single-stranded poly(UG) RNA through high affinity 1D lattice interactions. The N-terminal domain functions to accelerat...

nature.com

Steve Baker@sfbkr.bsky.social · 3w ago

lab 2.0 in Chicago in search of a postdoc! Pursue virus-host interactions, post-translational modifications, and RNA splicing. Excellent in oral and written communication, lab and project management, and an ability to supervise and mentor trainees. sfbkrlab.org www.careers.luc.edu/postings/35620

sfbkr lab

We study how host alternative splicing shapes the outcome of influenza virus infection — from cryptic isoforms that antagonize the polymerase to the ANP32 proteins that support it.

sfbkrlab.org

EPIGENETIC HULK@epigenetichulk.bsky.social · 4w ago

HAHAHAHAHAHAHAHAHAHAHAHAHAHA! EPIGENETIC HULK LIKE THIS SMASH! NO SMASH NOTES! www.cell.com/cell-genomic...

Single-cell 3D genome imaging shows super-enhancer hubs are rare, nonspecific, and neither necessary nor sufficient for transcriptional bursting

Super-enhancers have been proposed to cluster in the nucleus when compared to other genomic elements. Le et al. found that super-enhancer clustering was rare and driven by non-specific interactions. P...

cell.com