Really happy to share a link to our work showing that anti-progestin therapy could help prevent breast cancer before menopause. Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/... Brilliant team science

Anti-progestin therapy targets hallmarks of breast cancer risk

Nature - Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing...

urldefense.com

So proud of the exciting story from my PhD student Jakub Sumbal on contractile fibroblasts shaping branching morphogenesis! Fantastic collaboration with the lab of Zuzana Koledova in Prague! @sumbalovakoledova.bsky.social It just came out online, check it out here: rdcu.be/eIIKD

Contractile fibroblasts form a transient niche for the branching mammary epithelium

Nature Communications - Fibroblasts represent a heterogenous cell population but how their differences reflect their plasticity and origin is not fully understood. Here, the authors map the origin...

rdcu.be

Geometry first: how positional cues dictate fate in bilayered epithelia thenode.biologists.com/geometry-fir...

Geometry first: how positional cues dictate fate in bilayered epithelia - the Node

Behind the paper story focussed on research on early fate decisions in bilayered epithelia.

thenode.biologists.com

Congratulations to the team on all their hard work on developing this first of its kind model! @andreaventura.bsky.social @psalmotoxin.bsky.social @wtklab.bsky.social @kytsailab.bsky.social @moffittnews.bsky.social

Elizabeth McKenna@elizsmckenna.bsky.social · 11mo ago

Now online in Cancer Discovery @aacrjournals.bsky.social: An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole-Rat - by Alyssa Shepard, Daniel Lester, @kissillab.bsky.social, and colleagues doi.org/10.1158/2159... @moffittnews.bsky.social

Could this be the future of cancer prevention? Walid Khaled‬, a new ERC Advanced Grant recipient @cam.ac.uk‬, will work on a preventive vaccine for breast cancer. Learn more 👉 buff.ly/s6cBCwL #ERCAdG #CancerResearch #FrontierResearch @wtklab.bsky.social‬

Thank you @erc.europa.eu for highlighting PreBRCATx. I am excited where this grant will take will take our science - hopefully a step closer to therapeutic cancer prevention!

European Research Council (ERC)@erc.europa.eu · last yr.

The 2024 ERC Advanced Grants will help 281 researchers set up their own teams and conduct research on the topics of their choice. We selected 5 examples of projects; based in Spain, the Netherlands, Germany and the UK. Find out more 👉 buff.ly/Kuo67XK

Our latest paper from is out! Congratulations to all members the lab that contributed over the years! No UMAPs in this one! @phar.cam.ac.uk @scicambridge.bsky.social Thanks to our funders @cancerresearchuk.org @breastcancernow.bsky.social

The EMBO Journal@embojournal.org · last yr.

CHD8 interacts with BCL11A to induce oncogenic transcription in triple negative breast cancer @wtklab.bsky.social and collaborators www.embopress.org/doi/full/10....

Join our Prevention Primer on 24 June and grow your knowledge ahead of @cancerresearchuk.org's #PrevConf25. Hear from Prof Peter Sasieni, @sarahblagden.bsky.social, @wtklab.bsky.social and others, inc lab scientists, clinicians, behavioural scientists and epidemiologists.

Great opportunity in our department 👇👇 www.jobs.cam.ac.uk/job/44592/

Check out the final programme for ENBDC (23-26 April) now with 7 short talks selected from the abstracts. Last 8 spots still available but you need to be quick! We can accept applications till 31st March.

We are looking for a doctoral candidate to join the lab! If you are interested in working with human breast tissue samples straight from the clinic and do not fear large data sets, this might just be your dream project ☺️ Apply now ⬇️ ats.talentadore.com/apply/vaitos... 📸 @oonapaavolainen.bsky.social

Lab’s latest: (mouse) mums grow their guts during pregnancy and lactation: www.cell.com/cell/fulltex...

Linsey Porter in our lab is running the Cambridge half marathon for this worthy cause 👇👇. Please support if you can. www.givengain.com/project/lins...

Music therapy for those living with dementia

Hello everyone! My name is Linsey, and my husband Alan and I are excited to support the Saffron Hall Trust through my fundraising campaign on GivenGain. The Trust uses music therapy for many different...

givengain.com

JOB ALERT (9 days to go) We are looking for a computational postdoc to lead on the analysis of the NMGN Ageing Cluster spatial transcriptomics dataset. Start date: Flexible Tenure: 3 years Deadline: 28th Feb 2025 Informal queries welcome! Please RT

Walid Khaled@wtklab.bsky.social · 2y ago

JOB ALERT We are seeking a Computational Research Assistant or Research Associate to help drive an ambitious multiomics ageing project part of the NMGN Mouse Ageing Cluster. www.jobs.cam.ac.uk/job/49939/ @scicambridge.bsky.social @phar.cam.ac.uk @cambridgebiosci.bsky.social

Deadline extended to 28th Feb!

Walid Khaled@wtklab.bsky.social · 2y ago

JOB ALERT We are seeking a Computational Research Assistant or Research Associate to help drive an ambitious multiomics ageing project part of the NMGN Mouse Ageing Cluster. www.jobs.cam.ac.uk/job/49939/ @scicambridge.bsky.social @phar.cam.ac.uk @cambridgebiosci.bsky.social

JOB ALERT We are seeking a Computational Research Assistant or Research Associate to help drive an ambitious multiomics ageing project part of the NMGN Mouse Ageing Cluster. www.jobs.cam.ac.uk/job/49939/ @scicambridge.bsky.social @phar.cam.ac.uk @cambridgebiosci.bsky.social

🚨 Excited to announce that we are hiring 🚨 If bowel disease, pain, & naked mole-rats are your thing then we have the perfect opportunity for you 😃 This ChatGPT image shows a naked mole-rat with visceral pain, but they actually appear resistant #PainResearch

Registration is now open for the 16th ENBDC workshop 24-26 April 2025 Great line-up of speakers 👇 6 selected talks from abstracts ✍️ Limited spaces available. Sign up early to avoid disappointment! enbdc.org/workshop/

We are forming a patient advisory group to help shape our research on BRCA breast cancer prevention! Follow the link/scan the barcode for more info and to express interest. Please share! @wtklab.bsky.social www.stemcells.cam.ac.uk/about-us/eng...

First post on here! Looking forward to sharing what we learnt over the years from studying the mouse and human breast at the single cell level! @crukcamcentre.bsky.social @sabcs.bsky.social @cancerresearchuk.org www.sabcsmeetingnews.org/plenary-lect...

Plenary Lecture to explore breast cell atlas in cancer prevention, treatment - SABCS Meeting News

Walid Khaled, PhD, will deliver the second plenary lecture during the 2024 San Antonio Breast Cancer Symposium® about cell atlases as roadmaps in cancer immunology.

sabcsmeetingnews.org

Earlier this year, we published an article in Cancer Discovery discussing six hallmarks of precancer and highlighting the need for a multi-omics approach to research in this area. aacrjournals.org/cancerdiscov... Would love to connect with others working in this area!

The Hallmarks of Precancer

Summary:. Research on precancers, as defined as at-risk tissues and early lesions, is of high significance given the effectiveness of early intervention. We discuss the need for risk stratification to...

aacrjournals.org