📣Excited to share my last postdoc paper with @soumya-boston.bsky.social on eQTL mechanisms depending on where the RNA is in the cell! @broadinstitute.org @harvardmed.bsky.social TL;DR:Early RNA eQTL variants in the nucleus and late RNA eQTL variants in the cytosol have distinct molecular mechanism🧵

bioRxiv Genomics@biorxiv-genomic.bsky.social · last yr.

Early and late RNA eQTL are driven by different genetic mechanisms https://www.biorxiv.org/content/10.1101/2025.02.24.639351v1

Excited to tell you about VIMA (Variational Inference-based Microniche Analysis), our deep learning + stats hybrid for case-control analysis of multi-sample spatial molecular datasets. 🧵👇 www.biorxiv.org/content/10.1... @soumya-boston.bsky.social @broadinstitute.org

Powerful and accurate case-control analysis of spatial molecular data with deep learning-defined tissue microniches

As spatial molecular data grow in scope and resolution, there is a pressing need to identify key spatial structures associated with disease. Current approaches often rely on hand-crafted features such...

biorxiv.org