Tessera

Amit Yaron @yaronamit.bsky.social · last yr.

New @plosbiology.org paper: doi.org/10.1371/jour... We found neurons in rat auditory cortex that signal narrow predictions for specific tones. Using omissions as a probe, we show that some neurons show frequency-specific expectations despite responding broadly to actual sounds. 🧵

Auditory cortex neurons that encode negative prediction errors respond to omissions of sounds in a predictable sequence

Neurons encoding positive or negative prediction errors signal a mismatch between the expected and the experienced input. This study shows how neurons encoding negative prediction errors in the audito...

doi.org

PLOS Biology @plosbiology.org · last yr.

The sound of silence? @yaronamit.bsky.social &co show how #neurons encoding negative #PredictionErrors in the #AuditorySystem compute the omission of sounds in a predictable tone sequence (incl asymmetry between bottom-up receptive field & top-down predictive field @plosbiology.org 🧪 plos.io/4n61zeq

Left: Experimental design featuring eight conditions with two distinct tones (A and B) and a 5% omission rate, presented in random order. Each condition comprised 1,000 stimulus items, varying the probability of Tones A and B to achieve different predictability levels. Top right: Example of a neuron that responds to tones but not to omissions. The raster plot shows spikes (black dots) with time (ms) on the x-axis and trials on the y-axis. The PSTH displays firing rate over time, with tone stimuli (blue shading) and omissions (gray shading). The black line represents the firing rate, the red line shows omission responses, and the green line indicates the omission baseline. Bottom right: Example of a neuron that selectively responds to the omission of specific tones. The same representation is used as in top right.