We are excited to share our latest preprint on surface protein QTL mapping & experimental fine-mapping of the CD40 autoimmune locus in B cells w/ @soumya-boston.bsky.social @broadinstitute.org @mgbresearch.bsky.social ! 🧬🧵👇 🔗 www.biorxiv.org/content/10.6...
Identifying the causal allele in the CD40 autoimmune locus enables discovery of context-specific trans-effects in B cells
Thousands of genetic variants are associated with autoimmune diseases, but causal variants, their mechanisms, and the pathogenic context in which they act are elusive. Knowledge of pathogenic contexts...
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