Memories can survive even after the brain temporarily loses more than half of its synaptic connections, according to a new mouse study in Science, which challenges the long-held view that long-term memories depend on stable individual synapses. Learn more: https://scim.ag/4zhsCK2

Artificial hibernation reveals synaptic engram architecture associated with memory retention

Memories leave lasting physical changes at the synaptic level. Although stable, larger spines are thought to support memory, the high turnover of dendritic spines and the drifting of neuronal represen...

scim.ag

After a great time in Toronto, I spent the last four months of my gap year at Tom(@tommchugh.bsky.social)’s lab at RIKEN CBS. Thanks to Tom and the kind lab members, I made much progress on my project and gained a lot of experience and insight. Thank you for this wonderful opportunity!

[Cell cover] New issue of Cell out today, with my cover illustrating “Whole-organ and whole-body 3D atlases enable cellome-wide profiling.” Congratulations to Dr. Ueda, Yoshida-san and Matsumoto-san!!🎉

Cell - a Cell Press journal@cp-cell.bsky.social · 7mo ago

New issue alert 👉 www.cell.com/cell/current On the cover: Yoshida et al. present 3D, single-cell-resolution atlases of multiple adult mouse organs and of the entire neonatal mouse. The artwork reimagines Klimt's decorative motifs to reflect the organization and vast scale of individual cells.

Today was the final day of my three-month stay in Paul and Sheena’s lab. It was short, but filled with unforgettable moments. I love the lab, the people, and this city. I can’t put into words how grateful I am for everything. Thank you so much, @franklandlab.bsky.social and @sjo09.bsky.social

New paper from the lab 🚨 Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age: authors.elsevier.com/a/1lzT-3BtfH...

Excited to share our new preprint: Blockade of associative spine enlargement impairs awake cortical function biorxiv.org/content/10.1...

New paper from the lab led by Ali Golbabaei. If you’re interested in systems consolidation, generalization and hippocampal neurogenesis a short 🧵 follows: authors.elsevier.com/a/1lsO73QW8S...

Arrived in Toronto!!

Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation. rdcu.be/el18q A short thread follows for those interested. 1/n

Systems consolidation reorganizes hippocampal engram circuitry

Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...

rdcu.be

I’m excited to share my first review! I explore diverse synaptic mechanisms underlying episodic memory, with a special focus on an optogenetic tool for canceling LTP induction, established by my wonderful mentors. I’d love to hear your thoughts and feedback! www.sciencedirect.com/science/arti...