A long-standing question in neuroscience is why the eCB system uses two ligands for the same receptors and how their release differs. To address it, we’re happy to share a pair of selective GRAB sensors that detect 2-AG and AEA, respectively, in real time. biorxiv.org/content/10.6...

Join us at #FENS2026 for Chinese-European Frontiers in Neuroscience, a CNS Satellite Event! Co-chaired by Profs. Yulong Li & Rosario Moratalla, with leading researchers exploring pain research & neuromodulation while fostering CN-EU collaboration. 📍 Barcelona | 📅 July 5

Excited to share our first red ACh sensor! 🔴 We developed GRAB_rACh1h, the first genetically encoded red fluorescent sensor for recording acetylcholine dynamics in vivo. (1/3)

(1/3)Excited to share PKU tags—our lab’s latest contribution expanding the toolkit for cell-type labeling with a new shape dimension! Developed at PKU, these genetically encoded tools enable multiplex cell-type labeling compatible with both light and electron microscopy.

We’re bringing our latest progress in neuromodulator imaging to #SfN2025! Don’t miss Dr. Li’s talk (Nov 19) and our lab’s posters (Nov 16). We look forward to connecting, exchanging ideas, and exploring collaborations. #neuroscience #neuroimaging #biosensors @sfn.org

Glad to see Yu Zheng PhD @zheng-yu.bsky.social highlighting the far-red dopamine sensor for multiplex imaging of in vivo neuromodulation. Happy to share these probes to the community.

Nature Reviews Neuroscience@natrevneuro.nature.com · last yr.

A far-red dopamine sensor unlocks multiplex views of in vivo neuromodulation — a Tools of the Trade article by Yu Zheng #neuroscience #neuroskyence www.nature.com/articles/s41...

1/ Excited to share a new preprint! Our latest study uncovers how serotonin precisely controls the “time window” for fear learning, ensuring that our brains link cues (CS) & threats (US) only when it’s adaptive. #Neuroscience #FearLearning www.biorxiv.org/content/10.1...

Serotonin shapes the temporal window for associative fear learning

Fear learning is a critical adaptive mechanism that enables the association of an environmental cue (the conditioned stimulus, CS) with a potential threat (the unconditioned stimulus, US), even when t...

biorxiv.org

(1/3) Excited to introduce our new GRAB sensors for a series of steroid hormones! These tools enable real-time detection of steroid hormone dynamics in vivo🐭🧠. Happy to share these sensors and welcome any feedback! Please contact yulonglilab2018@gmail.com for information.

Excited to share our Science paper on HaloDA1.0-the first genetically encoded far-red dopamine sensor! 🥳It enables powerful multiplex imaging in neurons, brain slices, and live animals.🧠🔬 #GRABsensors #Dopamine www.science.org/doi/10.1126/...

In vivo multiplex imaging of dynamic neurochemical networks with designed far-red dopamine sensors

Dopamine (DA) plays a crucial role in a variety of brain functions through intricate interactions with other neuromodulators and intracellular signaling pathways. However, studying these complex netwo...

science.org

Deepest thanks to @yulonglilab.bsky.social and all those who attended his seminar on GRAB sensors in neuromodulator dynamics hosted by @maximoprado.bsky.social at @westernu.bsky.social.

Big thanks@westernu.bsky.social @westernubrainscan.bsky.social @tridentpct.bsky.social for inviting! Loved presenting our GRAB sensor work and the great discussions. Hope to visit again!

Marco A. Maximo Prado@maximoprado.bsky.social · last yr.

It has been an enormous pleasure to host @yulonglilab.bsky.social at @westernu.bsky.social @westernubrainscan.bsky.social @tridentpct.bsky.social MouseTRAP seminar series presenting on GRAB sensors and neuromodulators

Join the "Genetically-Encoded and Chemigenetic Tools for Analysis and Control of Biological Systems" symposium at #ChemPacific2025! Explore cutting-edge tools alongside other world-class science in Hawaii. 🌴🌴 pacifichem.org

Thrilled to share our latest research published in Nature Communications! Our new GRAB sensor of SNPF promotes discoveries in the dynamics and molecular regulation between neuropeptide and neurotransmitter release in vivo. Check out the full paper here: www.nature.com/articles/s41...

(1/6) Excited to introduce our first generation red acetylcholine sensors! #acetylcholine #GRAB #RedSensors www.biorxiv.org/content/10.1...

Red-shifted GRAB acetylcholine sensors for multiplex imaging in vivo

The neurotransmitter acetylcholine (ACh) is essential in both the central and peripheral nervous systems. Recent studies highlight the significance of interactions between ACh and various neuromodulat...

biorxiv.org

First post on Bluesky!✨ (1/7) Far-red dopamine sensor is coming! Excited to introduce our chemigenetic DA sensor, HaloDA1.0! #Dopamine #FarRedSensors, #GRAB www.biorxiv.org/content/10.1...