Happy to share that my review "Clues for glues: from serendipity to nature's blueprints in degrader discovery" is now out: doi.org/10.1042/EBC2... The field is moving fast, and there’s no shortage of open questions - what a great time to be thinking about where #molecularglues and #TPD go next!
Clues for glues: from serendipity to nature’s blueprints in degrader discovery
Molecular glue degraders (MGDs) are small molecules that promote interactions between an E3 ligase and a target protein, reconfiguring recognition to trigger proteasome-mediated degradation. Their dis...
doi.org
Targeted protein degradation community@tpd-community.bsky.social · 9mo agoMolecular glue degraders don't just block proteins; they reprogram cellular recognition logic to eliminate "undruggable" targets entirely. Clues for Glues review by @zkozicka.bsky.social doi.org/10.1042/EBC2...
