We keep on investigating the role(s) of G-quadruplex #G4 in aging and found a quite interesting correlation between age and the level of both G4s and related G4 helicase (particuarly here: DDX3X). With @mcgovernpeds.bsky.social In Cell Death Dis. @springernature.com 👉 doi.org/10.1038/s414...

If you're working with guanine (G)-rich DNA/RNA sequences and want to know whether they fold into G-quadruplex (G4) structures—and which topology they adopt—it can now be done with the naked eye.. or almost! 🔬 Now in @sciencechinapress.bsky.social @springernature.com 👉 doi.org/10.1007/s114...

And many thanks to Juan Carlos for the tour around Granada (and for the famous tapas!) 🇪🇸

David Monchaud@dmonchaud.bsky.social · 2mo ago

I am very happy and honored to have been invited to this wonderful institute. Many thanks to Juan Carlos Morales for the invitation and to all the PIs with whom I had the privilege of exchanging ideas 👍

I am very happy and honored to have been invited to this wonderful institute. Many thanks to Juan Carlos Morales for the invitation and to all the PIs with whom I had the privilege of exchanging ideas 👍

IPBLN-CSIC @ipblncsic.bsky.social · 3mo ago

Today Dr. David Monchaud (ICMUB, Dijon, France) has given a seminar at the IPBLN. Titled: “Chemical Modulation of DNA/RNA G-Quadruplex (G4) Structures in Human Cells”.

"A 𝘸𝘦𝘭𝘭-𝘸𝘳𝘪𝘵𝘵𝘦𝘯 𝘢𝘯𝘥 𝘧𝘢𝘴𝘤𝘪𝘯𝘢𝘵𝘪𝘯𝘨 𝘢𝘳𝘵𝘪𝘤𝘭𝘦 𝘢𝘣𝘰𝘶𝘵 𝘵𝘩𝘦 𝘦𝘢𝘳𝘭𝘺 𝘩𝘪𝘴𝘵𝘰𝘳𝘺 𝘰𝘧 𝘢𝘭𝘵𝘦𝘳𝘯𝘢𝘵𝘪𝘷𝘦 𝘋𝘕𝘈 𝘴𝘵𝘳𝘶𝘤𝘵𝘶𝘳𝘦𝘴. 𝘐𝘵'𝘴 𝘢𝘯 𝘪𝘮𝘱𝘰𝘳𝘵𝘢𝘯𝘵 𝘤𝘰𝘯𝘵𝘳𝘪𝘣𝘶𝘵𝘪𝘰𝘯" I am deeply honored and super proud to receive such feedback from 𝗦𝘁𝗲𝗽𝗵𝗲𝗻 𝗡𝗲𝗶𝗱𝗹𝗲 (UCL London, UK), one of the founding fathers of the field of alternative #DNA structures.

Nucleic Acids Research@narjournal.bsky.social · 3mo ago

🧬 A new review article highlights 50 years of discoveries describing DNA’s many alternative forms which have trailblazed nucleic acid research. Read the full article at academic.oup.com/nar/article/... #DNAResearch #GenomeBiology #NucleicAcidsResearch #MolecularBiology #HistoryofDNA

With the goal of further developing our #G4 molecular helicase 𝗣𝗵𝗽𝗖, we—in collaboration with Carla Cruz @ubeirainterior.bsky.social—have investigated the biodistribution of this molecule using gold nanocarriers for controlled release. Now in JDDST @elsevierlsj.bsky.social 👉 doi.org/10.1016/j.jd...

In Genome Biol. @springernature.com we report on: 1/ the 𝗮𝗻𝘁𝗶𝗰𝗮𝗻𝗰𝗲𝗿 𝗮𝗰𝘁𝗶𝘃𝗶𝘁𝘆 of the G-quadruplex #G4 stabilizer 𝗤𝗡-𝟯𝟬𝟮 and a 𝘀𝘆𝗻𝘁𝗵𝗲𝘁𝗶𝗰 𝗹𝗲𝘁𝗵𝗮𝗹𝗶𝘁𝘆 𝘀𝘁𝗿𝗮𝘁𝗲𝗴𝘆 to improve it, and 2/ the genoprotective role of the G4 unwinder 𝗣𝗵𝗽𝗖 With @ucllifesciences.bsky.social & @westernu.ca 👉 doi.org/10.1186/s130...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Modulating PhpC bioavailability and cellular activity in lung cancer cells via gold nanoparticle functionalization With @ubeirainterior.bsky.social and @westernu.ca Now in JDDST @elsevierlsj.bsky.social 👉 doi.org/10.1016/j.jd...

🧬 A new review article highlights 50 years of discoveries describing DNA’s many alternative forms which have trailblazed nucleic acid research. Read the full article at academic.oup.com/nar/article/... #DNAResearch #GenomeBiology #NucleicAcidsResearch #MolecularBiology #HistoryofDNA

Happy to take you behind the scenes of the discovery of 7 alternative #DNA structures: 𝘁𝗿𝗶𝗽𝗹𝗲𝘅, G-quadruplex (𝗚𝟰), 𝗶-𝗺𝗼𝘁𝗶𝗳, both 3- and 4-way 𝗗𝗡𝗔 𝗷𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝘀, 𝗥-𝗹𝗼𝗼𝗽 and the left-handed duplex 𝗭-𝗗𝗡𝗔. Hope you'll enjoy this journey back in time! In @narjournal.bsky.social 👉 doi.org/10.1093/nar/...

It was super great to welcome Chun Kit Kwok, from CityUHK, for a 2-day visit in our lab. A very enjoyable time discussing science in general, with of course a deep dive into RNA and G-quadruplex #G4 RNA. Thank you for coming!

The DNA damaging properties of the experimental G-quadruplex (G4) drug QN-302 are potentiated by the DNA repair inhibitor Olaparib and mitigated by the molecular helicase PhpC https://www.biorxiv.org/content/10.64898/2026.02.06.704351v1

Biocatalysts made of DNA, and G-quadruplex #G4 DNA in particular, have found a myriad of applications. But is there a real-life application reported so far? Thrilled to report this long-awaited example with the remediation of industrial wastewater! In @academic.oup.com doi.org/10.1093/nsr/...

FYI: the molecular helicase PhpC we developped to unfold G-quadruplex #G4 DNA and RNA both in vitro (see: shorturl.at/Ep8Il) and in human cells (e.g., shorturl.at/ue7rV, shorturl.at/zsheP & shorturl.at/MfUKW) is now commercially available at Idylle @idylle-labs.bsky.social 👉 shorturl.at/efE5l

Happy to be one of these guys going down the White Dune before swimming 10k across the Dakhla bay. 4 days, 4 stages, 4 adventures. Thank you Morocco Swim Trek 🙏 👉 moroccoswimtrek.com

How to recapitulate in vitro what happens in cells? Not easy! We investigated how guanine (G)-rich sequences interact with one another to decipher G4-associated gene expression regulation With Nanjing U & @polytechniqueparis.bsky.social @cnrs.fr In @narjournal.bsky.social: doi.org/10.1093/nar/...

A huge thank you to Jean-Louis Mergny, Jérome and Pascale @polytechniqueparis.bsky.social for organizing the "G-quadruplex (G4) made in France": two days filled with diverse and fascinating exchanges on the many facets of #G4 research!

Super proud of my team! They have simplified the synthesis of TASQs, enabling easier & faster access to these biomimetic G-quadruplex (G4) ligands used to image and identify cellular G4s. The TASQs story: doi.org/10.1021/acs.... This new article @chemistryeurope.bsky.social: doi.org/10.1002/chem...

A novel biotechnological application for G4s, used for controlling the activity of a CRISPR-Cas12a device used for diagnosing human viral infection (HPV) in a spatio-temporal manner Now in Anal. Chem. @pubs.acs.org With Nanjing U. & @polytechniqueparis.bsky.social @cnrs.fr doi.org/10.1021/acs....

The photoMultiTASQ is a new molecular tool to investigate G-quadruplex #G4 biology, notably for identifying G4 binding proteins by Chem-CLIP (chemical cross-linking and isolation by pull-down) In ACS Bio & Med Chem Au: doi.org/10.1021/acsb... With @iphc-strasbourg.bsky.social (FR) & WIS Rehovot (IS)

Stimulating scientific days #ChemBioParis2025. Super great to hear Shankar Balasubramanian speaking about G-quadruplex, Matthew Disney about ChemCLIP and Dan Nomura about MYC druggability, among many others Kudos to @borisvauzeilles.bsky.social & the team for the organization chembioparis2025.com

We’ve developed the first-ever method to control nucleic acid activity and gene-expressing synthetic cells with a deeply tissue penetrating alternating magnetic field 🧬 🧪 🧲!!! Published in *Nature Chemistry* Led by Ellen Parkes @syncelleu.bsky.social #chemsky www.nature.com/articles/s41...

Magnetic activation of spherical nucleic acids enables the remote control of synthetic cells - Nature Chemistry

The programmability of synthetic cells, comprising lipid vesicles that are capable of imitating the structure and function of living cells, facilitates their application as drug delivery devices. Now,...

nature.com

What happens when a DNA-junction binding compound is lengthened? Intriguingly, the larger pi surfaces widen the range of junctions targeted! Just out in JBIC -congratulations to authors Sam and Hannah -first paper from her MSc by research studies @uobchemistry.bsky.social doi.org/10.1007/s007...

Honored to have been interviewed by Pour La Science, a wide-audience scientific magazine, to discuss the results from @simonelsasser.bsky.social / @puckknipscheer.bsky.social published in @science.org about how DNA repair proteins mold G-quadruplex #G4 👉 tinyurl.com/3k6pxu6d (sorry, in French only)

Happy to describe a novel strategy to detect pollutants in food with a super high sensitivity, using G-quadruplex #G4 based biosensing devices. A collaboration with the University of Nanjing (CN) and Polytechnique Palaiseau (FR) Now in Anal. Chem. (@pubs.acs.org): doi.org/10.1021/acs....

Happy to describe a novel strategy to combat colorectal cancer by pharmacologically modulating G-quadruplex #G4 RNA found in dysregulated lncRNAs, using the molecular helicase PhpC. A collaboration with ITTGN (India) and supported by @embo.org fellowships Now in BMC Biol.: doi.org/10.1186/s129...

Ready for super-G4s? We have identified clusters of G4s in intergenic regions that act as super-enhancers in ovarian cancer cells, hence the name super-G4! These are de novo super-enhancers that are not underpinned by canonical epigenetic marks, supporting the epigenetic role of G4s rdcu.be/evXtf

Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)

RNA transcripts regulate G-quadruplex landscapes through G-loop formation

G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...

science.org

A novel demonstration of the G-quadruplex #G4 unfolding properties of PhpC, a quite unique prototype of G4 unfolder (or molecular helicase) we developed in the lab In collaboration with C. Cruz @ubeirainterior.bsky.social and R.H.E. Huson @westernu.bsky.social ‬ 👉 doi.org/10.1016/j.ij...

Call for Expressions of Interest – MSCA Postdocs 2025 Join my group at CiQUS to work on “Selective DNA Junction Binders for Targeted Anticancer Therapy”. Deadline: June 15 www.usc.es/ciqus/en/MSC... #MSCA #CiQUS #DNAJunctions #Postdoc #ChemSky #ChemBioSky