Sobre la importancia de programas específicos de optimización de antibioterapia (PROA) en oncología… jamanetwork.com/journals/jam...

Antibiotic Selection for Patients With Cancer Hospitalized With Infection

This secondary analysis of the 4 Intelligent Stewardship Prompts to Improve Real-Time Empiric Antibiotic Selection (INSPRE) cluster randomized clinical trials evaluates the association of computerized...

jamanetwork.com

Part 1 of a two-part series on outpatient antimicrobial stewardship interventions in immunocompromised patients: what has been studied, what are barriers to implementing interventions in this group, and how ASPs might overcome these challenges. doi.org/10.1017/ash....

Remdesivir and a monoclonal antibody (MBP134) will be tested against SOC. www.who.int/news/item/02... #IDsky Amazing PARTNERS initiative. Being able to run an adaptive platform trial in this situation is so needed and yet so impressive. Hats off for the team! @who.int

Patient enrolment begins in a scientific trial to identify the first effective treatments for Bundibugyo virus disease

In a major international effort to evaluate potential treatments for Ebola disease due to Bundibugyo virus (BVD), the PARTNERS clinical trial has opened enrolment today for patients in the Democratic ...

who.int

BK. Titanji@boghuma.bsky.social · 4w ago

Really impressive to see these trials underway. I remain hopeful for positive results showing an impact on mortality. www.theguardian.com/global-devel...

A (not so) new kid on the block! Temocillin proved non-inferior to carbapenems against 3GR-Enterobacterales. Hope to see this old drug widely available in Europe soon! 🤞🏻 www.thelancet.com/journals/lan... #AMSsky #IDsky

Temocillin versus carbapenems for bacteraemia due to third-generation cephalosporin-resistant Enterobacterales in Spain (ASTARTÉ): a multicentre, phase 3, open-label, non-inferiority, randomised clini...

In patients with bacteraemia caused by 3GCR-E, temocillin was non-inferior to carbapenems as targeted treatment. These findings support the use of temocillin as an effective and safe alternative to ca...

thelancet.com

c.org/NjjyxpJb68

Firma la petición

Creación especialidad enfermedades infecciosas como en el resto de la Unión Europea ¡YA!

c.org

Disappointing data on meningitis vaccine preventing Neisseria gonorrhoea infections Then again negative trial data is as useful as positive findings, so that we focus resources most effectively #IDSky www.nejm.org/doi/full/10....

Meningococcal B Vaccine to Prevent Neisseria gonorrhoeae Infection | NEJM

No vaccines are currently licensed for the prevention of Neisseria gonorrhoeae infection. Observational studies suggest that the four-component meningococcal serogroup B vaccine (4CMenB) may reduce...

nejm.org

Nurses boost AMS! #UTIsky #AMSsky

ASHE Journal@ashejournal.bsky.social · 4w ago

Can nurses lead outpatient UTI stewardship? This EHR-integrated triage tool improved symptom documentation, reduced unnecessary urine cultures, and cut antibiotic treatment of asymptomatic bacteriuria—all without increasing pyelonephritis. #ABXstewardship #NursingResearch doi.org/10.1017/ash....

Immunocompromised hosts should not be excluded from duration trials. The question is how we can safely incorporate them into these studies to generate the evidence we need. Our editorial in @cmijournal.bsky.social is freely available here: 🔓 authors.elsevier.com/a/1nOm-,RGPg... #IDsky #TxID #IDOnc

EcoRxChoice 🌍💊 lets users compare plastic waste from antimicrobial regimens, promoting eco-friendly prescribing. Supported by SIDP to boost sustainable antimicrobial stewardship.

🌟 The 2025 JCR Impact Factor for CMI has risen to 8.7! We thank our editors, reviewers, authors and readers for their dedication and extraordinary work. Read about how CMI did in 2025 here: clinicalmicrobiologyandinfection.org/article/S119... #IDSky #MicroSky #JIF #JCR2025

𝐍𝐞𝐰 𝐢𝐧 𝑵𝑬𝑱𝑴 𝑪𝒂𝒕𝒂𝒍𝒚𝒔𝒕 𝑰𝒏𝒏𝒐𝒗𝒂𝒕𝒊𝒐𝒏𝒔 𝒊𝒏 𝑪𝒂𝒓𝒆 𝑫𝒆𝒍𝒊𝒗𝒆𝒓𝒚! HealthPartners’ Antimicrobial Stewardship Program demonstrates the potential of centralized complex outpatient antibiotic therapy programs to optimize patient care. Learn more: https://nej.md/4uEs79k Explore the July issue: https://nej.md/3QMDUo2

We are genotyping and phenotyping the SNAP MSSA isolates for cefazolin inoculum effect. So we can look at cefazolin vs ASPs (randomized) treatment effect in CIE+, and compare to that in CIE-. I estimate several hundred (prob >400) in each CIE group.

Looking for a new antimicrobial stewardship metric? 👀 Authors from the VA have proposed a new "S3" option, which assesses the initiation, spectrum, and duration of therapy. 📖 Read more here academic.oup.com/cid/advance-... #AntimicrobialStewardship

The implications of this work is that we need look into body compartments to understand the inflammatory responses and can't simply rely on blood. Further, we need to tailor our treatments to the mechanisms identified- a simple "pneumonia=treatment X" is not going to work.

Great to see our new paper out in Nature Communications. In it we describe three novel phenotypes in lungs of patients with pneumonia. Pn1 -a non-neutrophil driven lung injury phenotype, Pn2-a balanced immune response with best recovery and Pn3-persistent inflammation driven by immature neutrophils

Pulmonary inflammation in severe pneumonia is characterised by compartmentalised and mechanistically distinct sub-phenotypes

Nature Communications - Analysis of cell samples from pneumonia patients may indicate specific phenotypes associated with disease. Here the authors use a multi-omics approach to analyse...

rdcu.be

Good news: C difficile diarrhea cases are decreasing in hospitals due to decreased antibiotic use Bad news: C difficile is increasing in the community, possibly due to widespread use of antibiotics in agriculture #IDSky

The OASIS RCT comparing olorofim vs amphotericin B for azole-resistant aspergillosis met its primary endpoint of non-inferiority for mortality (23% vs 24%), with fewer AEs (36% vs 64%), according to company report: www.shionogi.com/global/en/ne... Looking forward to the publication! #IDsky #IDOnc

Bringing #AMR into the outcome assessment of duration trials with the new DOOR-FRAME is very welcome! Larger samples and systematic AMR assessment among participants will be likely required to prove benefit academic.oup.com/ofid/article... #IDSky #AMSsky Awesome work by @seanong.bsky.social et al

Plastic pollution is pervasive across ecosystems. A Review in Nature Reviews Biodiversity summarizes current evidence on plastic exposure pathways, organismal responses and potential effects at higher levels of biological organization. go.nature.com/3QsA6rS 🌎🧪

Not all apples to apples. Editorial for this piece with a nice summary of available evidence for fosfomycin academic.oup.com/cid/advance-...

Antimicrobial Stewardship [vol.2] already running! Did we miss someone? 😉 #AMSsky #IDsky #MicroSky #PharmSky go.bsky.app/2qsEveQ

José Molina@josemolinagb.bsky.social · 2y ago

Hey, #IDSky stewards! How about a starter pack for antimicrobial stewardship? Use the tag #AMSsky in your posts to join the feed on this topic. Let’s make sharing easy! go.bsky.app/7KcDc2n

How could we define the best treatment duration for immunocompromised hosts? Happy to share our perspective in this editorial in @cmijournal.bsky.social, building on the recent BALANCE subanalysis for this vulnerable population www.sciencedirect.com/science/arti... #AMSsky #TxID #IDOnc #IDsky

The #FDA has approved #tebipenem pivoxil the first oral carbapenem antibiotic in the US for adults with complicated urinary tract infections. #IDsky #Medsky www.contagionlive.com/view/fda-app...

FDA Approves Tebipenem Pivoxil as First Oral Carbapenem For Complicated Urinary Tract Infections | Contagion Live

The FDA has approved tebipenem pivoxil (Utebzi), the first oral carbapenem antibiotic in the US for adults with complicated urinary tract infections (cUTIs), including pyelonephritis, providing an eff...

contagionlive.com

Wow! 🆕🔥🔴Multicenter OL NI RCT Oral fosfomycin (3 g once daily) was noninferior to continued intravenous therapy with carbapenems or BLBLIs when used as oral transition therapy for complicated UTIs caused by ESBL-producing Enterobacterales #IDSky #utisky academic.oup.com/cid/article-...

Fosfomycin as Oral Transition Therapy Versus Continued Intravenous β-Lactams for Complicated Urinary Tract Infections Caused by Extended-Spectrum β-Lactamase–Producing Enterobacterales: A Multicenter,...

Switching from intravenous antibiotics to oral fosfomycin was noninferior to continuing intravenous therapy for complicated urinary tract infections caused

academic.oup.com

The SNAP trial domain on cefazolin vs cloxacillin for MSSA bacteremia is finally published! www.nejm.org/doi/full/10.... Cefazolin is already the new standard! #IDsky #AMSsky

🎙️ Just published Communicable E56: Frequentist vs Bayesian for clinical trial analysis – 99% probability you’ll want to listen to this Hosted by Emily McDonald & Josh Davis with invited guests Roger Lewis & Ian Marschner 🌟 Listen on #Communicable: https://share.transistor.fm/s/7ea020d2 #IDSky

📣 If you have questions about fosfomycin, we have answers! Excellent review article by Tiffany Wu, Kalpana Gupta, @erinmccreary.bsky.social, Sarah Turbett & Jacob Lazarus on oral #fosfomycin & how to use it. #IDSky #clinmicro #UTISky #Medsky #Pharmsky www.cmi-comms.org/article/S295...

There’s enough evidence from observational and RCT subgroups to stop excluding systematically immunocompromised hosts from duration trials. Uncomplicated source + early response should always mean shorter. 1 in 3 patients in @shorten2trial.bsky.social is inmunocompromised bsky.app/profile/jose...

José Molina@josemolinagb.bsky.social · 2y ago

#ShorterIsBetter in immunocompromised hosts? Short treatments are feasible in early responders without source control issues. A significant number of observational studies serve as proof-of-concept on the feasibility of short courses in selected patients (see ⚠️) #AMSsky #IDOnc #TxID #IDsky

Excited to share an article that I've long awaited to share seeking to answer: What is the right dose of cephalexin/cefadroxil for SSTIs? We reviewed clinical studies & conducted PTA sims to elucidate this #IDSky @absteward.bsky.social accpjournals.onlinelibrary.wiley.com/doi/10.1002/...

Getting It Right the Second Time: How Can we Optimize First‐Generation Cephalosporin Dosing for Skin and Soft Tissue Infections in the 21st Century?

Optimal cephalexin and cefadroxil dosing for skin and soft tissue infections (SSTIs) is unclear. We summarize clinical and pharmacokinetic/pharmacodynamic (PK/PD) data that compare dosing strategies ...

accpjournals.onlinelibrary.wiley.com

REMAP-CAP domain on oseltamivir vs no-antiviral for patients admitted at ICU with influenza is stopped due to potential harm! 90d mortality: Oseltamivir=19.4% (62/319) No antiviral=13.7% (17/124) Last word for oseltamvir? What’s the rationale for harm? #IDSky www.remapcap.org/oseltamivir-...