Andrii Bugai
@abugai.bsky.social
Scientist at Aarhus University (DK). Alumni of the University of Helsinki (FI) and Kharkiv University (UA). I study how genes are regulated at the level of RNA.
🆕 publication! How do cells build their molecular machines? Tsimafei Navalayeu (Ameres lab) in @embojournal.org maps the stepwise assembly of the RNA exosome in mammalian cells, revealing the quality control mechanisms that ensure this essential complex is built correctly ➡️ tinyurl.com/84c2298e
East<->West Veil nebulae as seen from the North hemisphere. 180*10s stacks.
Super cool to see the result of our collaborative work with @heick.bsky.social 's lab finally out! Shaped through many discussions with @abugai.bsky.social, @lorenzoana.bsky.social & @max2max.bsky.social, @juliusbrennecke.bsky.social & Clemens, trying to decipher LENG8's secrets!
Plaschka lab@plaschkalab.bsky.social · 2mo agoNow published! We investigated how polyadenylated RNAs are targeted for decay in the human nucleus. www.nature.com/articles/s41... (1/5)
Nature research paper: Molecular basis of polyadenylated RNA fate determination in the nucleus go.nature.com/4vr9d7c
Molecular basis of polyadenylated RNA fate determination in the nucleus - Nature
Biochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to degradation.
go.nature.com
Now published! We investigated how polyadenylated RNAs are targeted for decay in the human nucleus. www.nature.com/articles/s41... (1/5)
Check out our latest research, just published in Nature @nature.com @molbiolau.bsky.social @au.dk Molecular basis of polyadenylated RNA fate determination in the nucleus www.nature.com/articles/s41...
Molecular basis of polyadenylated RNA fate determination in the nucleus - Nature
Biochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to degradati...
nature.com
How do cells distinguish functional genetic messages from molecular noise? Researchers in Clemens Plaschka's lab at IMP, together with Julius Brennecke's lab at IMBA and collaborators at Aarhus University, reveal a new principle of gene regulation: https://www.nature.com/articles/s41586-026-10650-0
Intrigued by a long-standing conundrum in small RNA biology—how nuclear Argonaute proteins silence transposons when they *need* target transcription for their own recruitment—we studied the piRNA pathway. And found a hidden RNA-decay axis from Piwi to the RNA exosome.
bioRxivpreprint@biorxivpreprint.bsky.social · 8mo agoRNA decay via the nuclear exosome is essential for piwi-mediated transposon silencing https://www.biorxiv.org/content/10.64898/2025.12.16.694471v1
Thrilled to share that I’ll be joining @imbmainz.bsky.social in February 2026 to start my own group! We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology. PhD positions available!
Check the highlights of our recent nuclear RNA sorting story here:
Ulrich Hohmann@hohmannulrich.bsky.social · 11mo agoHow are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)
Love RNA biology? Join us to explore the piRNA pathway with structural and genetic approaches (see 👇👇). PhD student/postdoc position co-supervised by Clemens Plaschka & myself. DM or email us if you’d like to know more! @vbcscitraining.bsky.social @imbavienna.bsky.social @impvienna.bsky.social
Julius Brennecke@juliusbrennecke.bsky.social · 11mo agoPIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity. But how does piRNA-guided target interaction translate into silencing? PhD student Júlia Portell Montserrat has an intriguing answer www.cell.com/molecular-ce...
Check out our latest preprint, focusing on how nuclear decay and export compete for poly(A)+ RNAs utilizing the same biochemical mechanism.
bioRxiv Molecular Biology@biorxiv-molbio.bsky.social · 11mo agoMolecular basis of polyadenylated RNA fate determination in the nucleus https://www.biorxiv.org/content/10.1101/2025.09.16.676470v1