Most animal species pack sperm DNA with protamines instead of histones. Protamines are essential for male fertility. They are among the fastest-evolving genes in animals. That makes little sense. We think we know why, in a new paper led by @ching-hochang.bsky.social. www.science.org/doi/10.1126/...

Rapid protamine evolution suppresses meiotic drive in Drosophila

Many animal species replace histones with protamines during spermatogenesis. Although essential for sperm function, protamines evolve rapidly for reasons that remain unknown. Using in vivo gene replac...

science.org

We’re recruiting postdocs! Join our Emerging Fields consortium to explore ribosome biology and translational control in pediatric cancers. My lab combines high-resolution Ribo-seq with unbiased genetic screens to uncover novel regulatory mechanisms. Deadline: 15 Nov 2026 lnkd.in/dmKJ7zbb

🤷🏿‍♂️

Using AI for just 10 minutes erodes your ability to persist at hard things - Berkeley News

A UC Berkeley researcher co-authored a study that raises profound questions about how we interact with artificial intelligence in education — and daily life.

news.berkeley.edu

If you are an NIH funded scientist and have not commented, you are agreeing that this change is a good idea. If, you, like me, think ditching peer review is a bad idea, take the 5 minutes and post a comment.

Coalition for Life Sciences@c4lifesciences.bsky.social · 2d ago

The deadline is approaching! NIH is proposing changes to how peer review is used in funding decisions and how outcomes are reported and they want to hear from you. Comments are due by October 13! Comment here: grants.nih.gov/grants/guide...

Have you ever looked at a gene in IGV or a genome browser and wondered “What are all those (ATAC-seq/H3K27ac/CTCF ChIP-seq/…) peaks doing?” 🤔 I’m thrilled to share that we developed a new technology called Swap-seq to answer that exact question. Swap-seq: www.biorxiv.org/content/10.6...

Systematic mapping of enhancers, silencers, and topological elements with prime editing deletion screens

Noncoding regulatory elements in the human genome can control gene expression through distinct mechanisms, including acting as enhancers, silencers, or topological elements. However, we lack tools to ...

biorxiv.org

🤯

Antoine Molaro@antoinemolaro.bsky.social · 3d ago

Hello World ! Its pre-print time ! Awesome collaboration led by Michel Cohen-Tannoudji (not on Bsky) and the one and only @deborahbourchis.bsky.social. #BFF We solved the molecular mechanism underlying a mysterious hybrid incompatibility in mice: the DDK syndrome. 🧵🍿 www.biorxiv.org/content/10.6...

I’m very excited to share my postdoc work in the @plaschkalab.bsky.social, where we investigated the very final act of splicing – spliceosome termination, revealing the stepwise dismantling of the spent spliceosome www.nature.com/articles/s41... (1/11)

Mechanism of spliceosome termination - Nature

A coordinated sequence of RNA helicases and associated factors dismantles normal and defective spliceosome complexes to enable intron degradation and ensure accurate gene expression.

nature.com

After excising an intron, the spliceosome gets trapped on the branched intron-lariat RNA. How are such dead-end spliceosomes terminated? Our latest paper led by @vytaute.bsky.social investigates the mechanism of spliceosome termination www.nature.com/articles/s41... (1/6)

DNA → RNA → protein. From single mRNAs to an entire developing vertebrate embryo, we can now watch this last step unfold in real time. Our paper is out today! 🐟🔬 www.science.org/doi/10.1126/...

Real-time single-molecule imaging in zebrafish embryos uncovers noncanonical translation

Precise spatiotemporal control of protein synthesis is essential during embryogenesis, yet directly measuring translation kinetics in vivo remains challenging in vertebrates. In particular, it remains...

science.org

Open #positions for #PhD students and #postdocs @mpi-nat.bsky.social in Göttingen 🇩🇪! Join the Grubmüller group and participate in exciting projects in the field of "Theory and Methods for Non-equilibrium #Theory and Atomistic Simulations of Complex #Biomolecules" #job #academic 🔗 s.gwdg.de/3XirxW

I am so proud of this achievement for Sascha. If you want to know about his amazing work that led to this award check out his two preprints: www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

Structural basis for the ubiquitin chain recognition of the human 26S proteasome

Proteasomal degradation is a fundamental process for all eukaryotic life. A protein destined for degradation is first tagged with a polyubiquitin chain, which is selected by the proteasome. Different ...

biorxiv.org

IMP@impvienna.bsky.social · 3d ago

Sascha Amann won the 2026 Rabitsch Award! 🏆 A recent PhD graduate from the CryoEM Technology Platform, Amann received the award for his research on how the proteasome recognises and degrades proteins tagged with ubiquitin: https://bit.ly/4hQTCs1

Now, the next chapter! Our lab at the Institute of Molecular Biology, Academia Sinica in Taiwan, is fully up and running. We are actively recruiting passionate researchers at all levels to tackle bold ideas in cell biology, chromosome architecture, and evolution: sites.google.com/view/ecg-lab...

ECG LAB

"The only constant in life is change." — Heraclitus Genetic conflicts — the good, the bad, and the ugly — shape our lives over time We aim to understand why even the most essential genes and chrom...

sites.google.com

mbg.au.dk/en/news-and-...

A decades-old mystery in RNA processing solved

Researchers at the Department of Molecular Biology and Genetics (MBG) together with collaborators in Denmark, France, and Germany, have uncovered the molecular explanation for an observation that has ...

mbg.au.dk

I am delighted to announce that The Department of Human Genetics at the University of Utah is continuing a multi-year recruiting initiative for multiple tenure-track faculty positions at the rank of Assistant Professor. Please share and consider applying! utah.peopleadmin.com/postings/208...

An other example of the value and beauty of fundamental biology research: we don’t always know what kind of future applications will be made possible by a basic discovery. This work in a single-celled alga open the doors to optigenetics 💡🧬

Nobel Prize@nobelprize.org · 6d ago

Peter Hegemann and Georg Nagel – awarded the 2026 medicine prize – discovered a remarkable protein, channelrhodopsin, in a single-celled alga. Hegemann wondered how Chlamydomonas, a single-celled alga, is able to swim towards a light source.

Eine sehr schöne Würdigung des unendlich kreativen Citoyens Boris Marte:

Nachruf Boris Marte (1964–2026): Der Gutes vermehrte

Mit dem Vorarlberger Kulturmanager Boris Marte verstarb einer der klügsten Köpfe des Landes – ein liberaler Intellektueller und Projektemacher, der an Veränderung glaubte.

falter.at

🧬 Mark your calendars! Our EMBO Workshop "Chromatin evolution from molecules to genomes" is coming to St Feliu de Guíxols (Spain), 4–7 Oct 2027 🌊 Amazing programme! #EMBOchromatinEvo meetings.embo.org/event/27-chromatin-evo Register early!

Chromatin evolution from molecules to genomes

Technological advances over the past decade have enabled genome-wide mapping of chromatin organization across diverse organisms at unprecedented resolution. These studies have uncovered both conserve…

meetings.embo.org

We have a position open in our core facility in the @pasteur.fr . Please share it and / or apply! forum.image.sc/t/research-e...

Research engineer in Bioimage Analysis. Institut Pasteur, Image Analysis Hub - 2026

Dear all Below is an announcement for a permanent position as a Research Engineer in the Institut Pasteur, Paris. There is a flyer attached at the bottom. We are looking ideally for a Bioimage An...

forum.image.sc

For my non-scientist followers who missed it, the Nobel Prizes come out this week. You’ll probably see me write a few words on them. As long as they’re not incredibly boring. Does that ever happen? (I’m kidding!)

Science Magazine@science.org · last wk.

Major discoveries—including the role of DNA, the biological basis of psychology, and the human genome—missed out on the Nobel Prize in Physiology or Medicine. Learn more: https://scim.ag/4hW4mq5

It's weird to live in a time where the Pope keeps making better statements on current affairs than any secular world leader seems able or willing to.

Dustin A. Chacón@lingdustin.bsky.social · last wk.

I've heard people make claims that AI would lead to a new Renaissance, but I didn't imagine it'd happen like this:

Interested in a career with UNEP? We regularly seek qualified individuals from around the world with skills to help safeguard the environment for future generations. See current vacancies here: https://unep.org/work-with-us

If you ever wondered why visible light is those particular wavelengths, it's because life evolved to see in the narrow range where water is transparent

Excited to share our new paper thanks to Tom Dix, @davidmcquarrie.bsky.social @yuantian23.bsky.social and the others @mcf-uom.bsky.social @fbmh-uom.bsky.social @manchester.ac.uk about multimerization of prototype RRM ELAV/Hu family RNA binding proteins.

Genes & Development@genesdev.bsky.social · 3w ago

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Multimerization of ELAV in Drosophila is essential for directing neuronal alternative splicing and polyadenylation programs By Dix et al. and Matthias Soller ➡️ https://ow.ly/jspT50ZPTe1 Matthias Soller David McQuarrie The University of Manchester #Drosophila

#TrendingNow | Sequencing of lab-cultured Drosophilidae species can result in a bias in taxon sampling. This study presents assembled #genomes from 183 single wild-collected drosophilids and inbred lines, aiming to redress the bias towards laboratory organisms 🧪 #ICYMI #Drosophila plos.io/3zS3Fe4

Single-fly genome assemblies fill major phylogenomic gaps across the Drosophilidae Tree of Life

Sequencing of species that can be cultured in the laboratory results in a bias in taxon sampling. This study uses cost-effective, amplification-free, low-input sequencing methods to assemble genomes…

plos.io

Princeton EEB is running a very broad faculty search at the Assistant Professor level. Please consider applying to join us! This is a wonderful, collaborative, cohesive department with diverse interests and amazing colleagues. apply.interfolio.com/193474

Two extremely cool new papers on how AID gets targeted to appropriate genes for somatic hypermutation: paper 1 from Schatz lab at Yale shows that NELF and elongation components of the SEC are required- and suggests NELF can travel into genes /1 www.nature.com/articles/s41...

Transcription pause and elongation regulators mediate somatic hypermutation - Nature

The molecular factors and mechanisms that mediate the chromatin recruitment of activation-induced deaminase and the generation of its stalled polymerase II substrate during somatic hypermutation are i...

nature.com

Come join us April 2027 for the next instalment of the EMBL Chromatin and Epigenetics meeting. Great invited speakers and lots of talks selected from abstracts! It will be a fantastic meeting (despite the egregious nucleosome images...)

EMBL Events@events.embl.org · 2w ago

Registration is now open for the EMBL Conference 'Chromatin and epigenetics' 🧬 Explore how epigenetic mechanisms shape human health and disease, and hear renowned speakers discuss the latest advances in the field #EMBLChromatin Submit your abstract by 19 January: s.embl.org/chr27-01-bl

UPDATE!: I am absolutely stoked that the second paper of my PhD is now out in @natcellbio.nature.com :D. We combined lipid imaging, STED microscopy, and mathematical modelling in a super cool team effort to quantify lipid partitioning inside clathrin-coated pits. www.nature.com/articles/s41....

Quantification of lipid sorting during clathrin-mediated endocytosis - Nature Cell Biology

Lennartz et al. evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma ...

nature.com

Our #genome still holds many mysteries… Want to help figuring out what is actually translated into proteins and how it is regulated? Our research network #ORFeus is looking for motivated #PhD students to join projects across Europe. Deadline is soon (Oct 22), have a look! www.orfeus-dn.eu/apply/

Apply to ORFeus — 15 fully funded PhD positions

15 fully funded PhD positions across Europe, starting 2027. Applications open 1 October and close 22 October 2026. Rank up to three projects.

orfeus-dn.eu

New from the lab! We uncover how the cap-binding complex promotes first-intron splicing: ZC3H18 recruits splicing factors while competing with the RNA-decay machinery, linking two alternative fates for newly made RNA. doi.org/10.1016/j.mo...