Agneesh Barua

@agneeshbarua.bsky.social

HFSP Long-Term fellow at the University of Lausanne. #Evolution #GeneExpression #Genetics

🚨🚨🚨 As part of the MSCA-DN DECODES, we're looking for a PhD student to study splicing programs in beta cells and diabetes at @melisupf.bsky.social @crg.eu Join 14 other PhD students across Europe to decipher the splicing code in human disease. More info below 👇 www.findaphd.com/phds/project...

DECODES at University of Santiago de Compostela on FindAPhD.com

PhD Project - DECODES at University of Santiago de Compostela, listed on FindAPhD.com

findaphd.com

How can a shared developmental programme generate the extraordinary diversity of teleost fishes? Our study suggests that the answer lies in the combination of conservation of network architecture, coupled with evolutionary flexibility in gene copy number. (1/8) doi.org/10.64898/202...

An evolvable and functionally partitioned network underlies developmental remodelling in teleosts

Comparative embryology has revealed that early animal development is based on highly conserved genetic programs. Beyond embryogenesis however, animals undergo remarkably diverse post-embryonic developmental transitions such as metamorphosis. Whether these transitions are also organised into conserved genetic programs remains largely unexplored. To identify conserved genetic programs underlying post-embryonic development, we examine metamorphic remodelling in five teleost fishes, spanning 200 million years of evolution. By integrating comparative co-expression networks, evolutionary genomics, phylogenetic modelling, and functional data in zebrafish, we uncovered a conserved post-embryonic developmental network. This conserved network comprises components involved in core cellular processes, and involved in development and physiology, both of which are under the control of thyroid hormone during metamorphosis. Despite evolutionary conservation at the coding sequence level, this network exhibits significant turnover in gene family copy number following the teleost-specific whole-genome duplication as well as lineage-specific expansions and contractions. The variation in gene copy numbers is associated with macroevolutionary variation in a number of ecological and morphological traits, including swimming performance and trophic level. Cross-species tissue expression, zebrafish single-cell transcriptomics, and zebrafish perturbation phenotypes placed the implicated genes in biological contexts relevant to these traits. Together, our results provide evidence of an ancient, functionally partitioned post-embryonic developmental network that has diversified throughout teleost evolution. The heterochronic variation in network function, changes in endocrine activity, and gene-family turnover provide potential routes through which a shared developmental architecture contributed to the evolution of phenotypic diversity in teleosts. ### Competing Interest Statement The authors have declared no competing interest. International Human Frontier Science Program Organization, LT0063/2022-L

doi.org

Desperately hoping people refer to this list before publishing. Decide who you want to serve, the community or for profit prestige selling publishers.

Roli Roberts@roliroberts.bsky.social · 2mo ago

Researchers in #EvolutionaryBiology & #Ecology wanting to do the right thing? @nicolasgaltier.bsky.social at #SMBE2026 talking about DAFNEE, a database of >600 #ecoevo #evoeco academia-friendly journals for "responsible publishing" - @plos.org seems to do OK here...!

Metamorphosis is a crucial transition across metazoans. How all the diverse lineages have evolved their own unique flavours of this transition is vital to understanding the origin of diversity itself. This study provides some clues, and most likely, some answers too.

bioRxiv Evolutionary Biology@biorxiv-evobio.bsky.social · 4mo ago

Gene family evolutionary dynamics reveal convergent genomic signatures in pancrustacean metamorphosis https://www.biorxiv.org/content/10.64898/2026.05.06.723392v1

Just look at that beauty! There is still so much we don't know about metamorphosis across teleosts. Hopefully we'll have some clarity in a few months 😜

Chris Gug@gugunderwater.bsky.social · 6mo ago

The rarest of the rare! This holy-grail dream fish is a larval-stage #monkfish, aka #goosefish. Shot in the wild, using scuba, while diving at night over water several thousand feet deep, several miles offshore from Kumejima, Okinawa. #larvalfish #blackwater #gug #deepseafish

Gonna refer to this every time to find the right journal. At a time when scientific funding is drying up everywhere, I think it is important to ensure that public funds to not get funnelled to for-profit publishers. Just another way to ensure public accountability.

Nicolas Clairis@nclairis.bsky.social · 7mo ago

Dear all, I'm happy to present you a side project done with @diegoharta.bsky.social @phylogenetrips.bsky.social & Lucas Baudouin regarding the publication landscape in Biology: wheretopublish.github.io 1/4

Our project on molecular convergence in teleosts is published in MBE. This study involved analysing over 2 million genes, and combining multiple data modalities to uncover some surprising insights behind the evolution of adaptations in teleosts. Thank you @hfspo.bsky.social for the funding!

Molecular Biology and Evolution@molbioevol.bsky.social · 8mo ago

Barua, @marcrr.ecoevo.social.ap.brid.gy et al. searched for convergent substitutions in teleost fishes, detecting convergence in 89 protein-coding gene families across 143 genomes. Functional experiments support functional roles of convergent genes. 🔗 doi.org/10.1093/molbev/msag015 #evobio #molbio

🦠🧬 A study published in @science.org today by SIB and other scientists used a new combination of bioinformatics methods to show that treponemal diseases were circulating far earlier in the Americas, and were more diverse, than previously known. See more👇 @davidebozzi.bsky.social

5,500-year-old genome discovered for syphilis-related bacterium

A bacterial genome found in the remains of an ancient hunter-gatherer shows that treponemal diseases were circulating far earlier in the Americas, and were more diverse, than previously known. Pu...

sib.swiss