Pyramidal cells in the cortex send a long apical dendrite to layer 1. What is its role? What happens when it's gone? ✂️ A causal spatial role for apical dendrites in the cortex Out today with @kenneth-harris.bsky.social, @carandinilab.net and @fedrossi.bsky.social www.biorxiv.org/content/10.6...

A causal spatial role for apical dendrites in the cortex

Cortical pyramidal neurons project a long apical dendrite to layer 1 (L1), to receive synaptic inputs that are thought to provide contextual and possibly suppressive modulation. In visual cortex, thes...

biorxiv.org

For years, neuroscientists have sought to reconcile conflicting findings about how brain activity relates to blood flow. A new study from the Simons Collaboration on the Global Brain suggests the answer lies in a hidden balance between two opposing groups of neurons: bit.ly/3QX90to

Deciphering the Link Between Neural Activity and Blood Flow in the Brain

For years, neuroscientists have sought to reconcile conflicting findings about how brain activity relates to blood flow. A new study suggests that the answer lies in a hidden balance between two oppos...

bit.ly

Looking forward to opening #FENS2026 with a fUSI-centric technical symposium on Monday 6 July (additional registration required!) 🤩 A great line-up to discuss opportunities and challenges in using functional ultrasound imaging for the study of internal states (and in general!). Come see us!

Losing one side of Superior Colliculus is bad, but losing both sides seems fine. Wait, what? Flora & team discovered why: both sides press for contra actions and against inaction, obeying an incredibly simple additive rule. Out today in bioRxiv: www.biorxiv.org/cgi/content/...

New @ucleye.bsky.social & @uclqsion.bsky.social research reveals a unified explanation for how neural activity shapes blood supply across the entire brain. www.ucl.ac.uk/brain-scienc... @carandinilab.net @agnesland.bsky.social

Brainwide blood flow is driven by two opposing neural networks, UCL study finds

New UCL-led research reveals a unified explanation for how neural activity shapes blood supply across the entire brain.

ucl.ac.uk

When it comes to blood flow in the brain, not all neurons are created equal. Rather, only a subset of neurons may be driving vascular changes, a new study finds. By @claudia-lopez.bsky.social #neuroskyence www.thetransmitter.org/neurovascula...

Arousal neuron activity explains brain blood flow in mice

The findings could impact how researchers interpret signals from techniques that use blood flow as a surrogate for neural activity.

thetransmitter.org

How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states! Out today in Nature: rdcu.be/fdC2A @uclbrainscience.bsky.social

New paper out 🎉 Awake fUSI is powerful, but motion can strongly bias the data, even in head-fixed experiments. In this paper, we tried to systematically characterize those artifacts, benchmark denoising strategies, and turn that into practical recommendations for awake fUSI of mouse brains. 1/12

Imaging Neuroscience@imagingneurosci.bsky.social · 4mo ago

New paper in Imaging Neuroscience by Samuel Le Meur-Diebolt, Thomas Deffieux, et al: Robust functional ultrasound imaging in the awake and behaving brain: A systematic framework for motion artifact removal doi.org/10.1162/IMAG...

All talks of the 2025 UCL #Neuropixels course are now available: www.youtube.com/playlist?lis... For more information on the course see the website: www.ucl.ac.uk/neuropixels/... And for those at #SfN, come say hi at the #Neuropixels booth (Number 3731) or at my Poster 👋. Happy Neuropixeling!

2025 UCL Neuropixels Course - YouTube

Lectures at the 2025 UCL Neuropixels course (https://www.ucl.ac.uk/neuropixels/training/2025-neuropixels-course)

youtube.com

Happy to see my last PhD paper (finally!) out 🥳 Cross-species ferret vs. human, fUSI vs fMRI, round 2! Is the human cortical hierarchical gradient in background invariance also found in ferrets? Yes! Are they supported by the same mechanisms? No! Find out more: 👉 elifesciences.org/articles/106...

Hierarchical encoding of natural sound mixtures in ferret auditory cortex

To parse foreground and background sounds, the auditory cortex of humans and ferrets share a similar hierarchical organization, but the underlying computational mechanisms are fundamentally different.

elifesciences.org

Join the 2025 UCL Neuropixels course (free and online!), 22-24th of October: Day 1 and 2: Get started with the basics and the latest updates on hardware & software. Day 3: Focus on how to analyse the many neurons you recorded. More info and to register: www.ucl.ac.uk/neuropixels/...

2025 Neuropixels course

A free online course on Neuropixels, 22-24 October 2025

ucl.ac.uk

Thrilled to share that our work is now published in Science! ✨ We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭 www.science.org/doi/10.1126/... 🧵1/

Two flagship papers from the International Brain Laboratory, now out in ‪@Nature.com‬: 🧠 Brain-wide map of neural activity during complex behaviour: doi.org/10.1038/s41586-025-09235-0 🧠 Brain-wide representations of prior information in mouse decision-making: doi.org/10.1038/s41586-025-09226-1 +

This looks pretty cool: ultrasound can now see through the skull! 🧠🔊 The skull has long been a barrier to ultrasound. This reprint shows how to make it quickly transparent → enabling full-depth, high-res fUSI in mice (& humans! 🤯🤯) Huge congrats to the authors!!! www.biorxiv.org/content/10.1...

Introducing our new favorite stimulus. A few minutes are enough to map the visual preferences of thousands of neurons. Mapping the visual cortex with Zebra noise and wavelets www.biorxiv.org/content/10.1... By Sophie Skriabine and Max Shinn, with Samuel Picard and @kenneth-harris.bsky.social

A new study led by @timothysit.bsky.social reveals that different layers of mouse V1 integrate visual and non-visual signals differently. Activity is dominated by vision (or spontaneous fluctuations) in L2/3 and by movement in L5. This leads to different geometries. www.biorxiv.org/content/10.1...

New by Agnès Landemard (@agnesland.bsky.social‬) & co Brainwide blood volume reflects opposing neural populations Brainwide fluctuations in blood volume arise from two populations with opposite relation to brain state and distinct relationships to blood supply www.biorxiv.org/content/10.1...