Pyramidal cells in the cortex send a long apical dendrite to layer 1. What is its role? What happens when it's gone? ✂️ A causal spatial role for apical dendrites in the cortex Out today with @kenneth-harris.bsky.social, @carandinilab.net and @fedrossi.bsky.social www.biorxiv.org/content/10.6...

A causal spatial role for apical dendrites in the cortex

Cortical pyramidal neurons project a long apical dendrite to layer 1 (L1), to receive synaptic inputs that are thought to provide contextual and possibly suppressive modulation. In visual cortex, thes...

biorxiv.org

Congratulations to Theodore D. Satterthwaite, recipient of the Flux Society 2026 Linda Spear Mid-Career Award! Ted’s work advances multimodal neuroimaging to understand brain development, psychiatric illness, and reproducible neuroscience. Read more: buff.ly/QQeZUM5 #Flux2026 #DCN

buff.ly

Come join us! 🔬🐣 The Piacentino Lab at Johns Hopkins @hopkinsmedicine.bsky.social is recruiting a postdoc to study membrane lipids, cell migration, and invasion in neural crest and embryonic models! @socdevbio.bsky.social @ascbiology.bsky.social #devbiol #cellbio #lipids

5/ Very grateful to my inspiring co-authors from across the spectrum of cognitive, clinical, and translational neuroscience: @helenagellersen.bsky.social @lorinanaci.bsky.social @gozziale.bsky.social @daniel-bor.bsky.social Read the full article here: doi.org/10.1038/s415...

Unlocking spontaneous cognition in the age of data science - Nature Reviews Neuroscience

Spontaneous brain activity is experimentally unconstrained. Embracing this freedom unlocks rich opportunities beyond task-based and naturalistic paradigms, the traditional Herculean pillars of constra...

doi.org

1/ What can resting-state neuroimaging offer cognitive and translational neuroscience🧠? Turns out: a lot! 🧵 Long in the making, short in the reading: “Unlocking spontaneous cognition in the age of data science" is out now in @natrevneuro.nature.com rdcu.be/ftWBh

Unlocking spontaneous cognition in the age of data science

Nature Reviews Neuroscience - Spontaneous brain activity is experimentally unconstrained. Embracing this freedom unlocks rich opportunities beyond task-based and naturalistic paradigms, the...

rdcu.be

We've just published a small opinion piece in Nature Reviews Neuroscience, arguing for the under-estimated utility of resting state neuroimaging data, given exciting new methods to analyse it. Work led by @loopyluppi.bsky.social www.nature.com/articles/s41...

Unlocking spontaneous cognition in the age of data science - Nature Reviews Neuroscience

Spontaneous brain activity is experimentally unconstrained. Embracing this freedom unlocks rich opportunities beyond task-based and naturalistic paradigms, the traditional Herculean pillars of constra...

nature.com

'At elite journals, editors play a central role, rejecting a large majority of submissions without formal peer review, recruiting specific outside experts as reviewers, and guiding authors in how to respond to them.' www.science.org/doi/10.1126/...

Editorial and peer review dynamics at elite general science journals

Analyses of deidentified data reveal complex interactions that quantify success at elite general science journals.

science.org

"Over the same period (2018-2025), biomedical papers that were never posted as preprints were retracted at roughly twice the rate of those that were."

Tracking claim changes from preprint to publication across 72,644 biomedical studies using large language models

Preprints now disseminate a large share of biomedical research before peer review. Because they have not yet passed peer review, some scientists regard preprint claims as unverified or potentially unr...

biorxiv.org

In-scanner thoughts contribute to resting-state functional connectivity pubmed.ncbi.nlm.nih.gov/42365014/ I've long thought that this is the "elephant in the room" of resting state #fMRI esp. for comparing groups. If two groups think & feel differently in the scanner, of course rsfMRI will differ!

Dimensionality reduction is how the brain acquires knowledge. Cool new paper from the late, great, Mark Stokes. www.nature.com/articles/s41... #neuroscience

Learning shapes neural geometry in the primate prefrontal cortex - Nature Neuroscience

Learning transforms prefrontal cortex activity from flexible, high-dimensional representations into compact, task-relevant and abstract codes, enabling efficient generalization of learned rules to new...

nature.com

Happy to share that our paper on objective quality assessment for "precision" fMRI is now out in @cp-neuron.bsky.social A recap of what it does, what's new since the preprint, and code you can run on your own data. cell.com/neuron/fullt...

Evidence is mounting that there are distinct subtypes of autism, and now, scientists have found that the condition can vary according to the strength of people's brain connections

Autism may have two distinct subtypes that vary by brain activity

Evidence is mounting that there are distinct subtypes of autism, and now, scientists have found that the condition can vary according to the strength of people's brain connections

newscientist.com

We are delighted to announce that Shella Keilholz will shortly become the Editor-in-Chief of Imaging Neuroscience, following the selection process described in our Author Guide. Steve Smith is stepping down as EiC after serving for three years, following the transition from NeuroImage.

With OHBM 2026 starting tomorrow, I’m excited to share this perspective piece @gozziale.bsky.social and I contributed to @apertureohbm.bsky.social State of the Brain 2025 collection! 🧠 doi.org/10.52294/001...

🎧 OHBM Podcast Neurosalience is back with the inside scoop on OHBM 2026! We sit down with the organizers to chat keynotes, sessions, Bordeaux tips, and the new meeting app. Tune in now! 🧠 Spotify: open.spotify.com/episode/63E0... YouTube: youtu.be/z6jr13zNSeU

Our latest, led by @ivaili.bsky.social out now in Nature Mental Health using normative modelling to understand the heterogeneity of atypical FC in autism. Peep the thread...

Iva Ilioska@ivaili.bsky.social · 2mo ago

Our paper “Multiscale heterogeneity of atypical functional connectivity in autism” is now out in Nature Mental Health www.nature.com/articles/s44... With @alexfornito.bsky.social, Jan Buitelaar, Marianne Oldehinkel

✨ The State of the Brain 2025 features leading voices from last year's Annual Meeting, highlighting major advances in brain imaging research 🔗 apertureneuro.org/issue/13963-... @lucinauddin.bsky.social @elvisha.bsky.social @sharnajamadar.bsky.social @gozziale.bsky.social @adeelrazi.bsky.social

So glad to finally share work years in the making! What started with fMRI effect size benchmarks ended up showing that conventional study planning detects ~half of expected brain effects, suggesting more distributed processes than the lit shows (+ new methods for mass univ effect/power estimation)

In a meta-analysis of 210 biomedical AI studies that statistically compared models under cross-validation, 97% used invalid statistical tests. Here's our new preprint doi.org/10.64898/202... led by @tianchu.bsky.social @hetuli.bsky.social @shaoshiz.bsky.social @nichols.bsky.social 1/N

Very grateful to @shihyyi.bsky.social and colleagues for this thoughtful News & Views on our study www.nature.com/articles/s41... Especially meaningful coming from one of the leading voices in translational fMRI : ) 👇

Ian Shih@shihyyi.bsky.social · 3mo ago

Using fMRI data from 20 mouse models and large human cohorts, a recent study in @natneuro.nature.com identifies two dominant dysconnectivity patterns linked to distinct molecular signatures in #autism. See our summary and perspectives on the latest work from @gozziale.bsky.social lab: rdcu.be/fiSOL

Our preprint has grown up, and it is now out in @natneuro.nature.com Bottom line: variable patterns of brain connectivity in #autism can reflect distinct underlying biological mechanisms 🧠🐭 Paper: www.nature.com/articles/s41... Mouse fMRI datasets: tinyurl.com/44dwe6dz Detailed explainer below👇

Autism subtypes identified using cross-species functional connectivity analyses - Nature Neuroscience

Pagani et al. used cross-species fMRI to reveal two autism subtypes, characterized by lower and higher brain connectivity and linked to synaptic and immune-related pathways, respectively.

nature.com

Alessandro Gozzi@gozziale.bsky.social · last yr.

Can we use brain scans to identify biologically distinct "autisms"? And If so, how? In our latest cross-species study 🐭👨 with @iitalk.bsky.social we dive into these questions! Find out more here 👇👇 www.biorxiv.org/content/10.1... Thread below 🧵 1/n

🚨 The actual paper is now out on @cp-trendscognsci.bsky.social: www.sciencedirect.com/science/arti... In this opinion piece, @duncanastle.bsky.social and I explore the human brain through the lens of optimality and Pareto-optimality theory.

Embracing the suboptimal organization of the human brain

Human brain architecture is guiding brain-inspired artificial intelligence (AI) and has been treated as an optimal template, whose deviations could ma…

sciencedirect.com

Kayson Fakhar@kayson.bsky.social · 4mo ago

For all the esteemed scholars out there who prefer gaining knowledge the correct way, here’s a summary of our upcoming opinion piece, delivered to you by Jesus himself. But seriously, science communication is about to get a lot worse and better at the same time.

Very excited about this project, led by @zachladwig.bsky.social We show that an individual’s lateral prefrontal cortex has reliable and highly detailed network organization missed in past group approaches. Full🧵 coming soon!

Neuron@cp-neuron.bsky.social · 3mo ago

Our preprint has grown up, and it is now out in @natneuro.nature.com Bottom line: variable patterns of brain connectivity in #autism can reflect distinct underlying biological mechanisms 🧠🐭 Paper: www.nature.com/articles/s41... Mouse fMRI datasets: tinyurl.com/44dwe6dz Detailed explainer below👇

Autism subtypes identified using cross-species functional connectivity analyses - Nature Neuroscience

Pagani et al. used cross-species fMRI to reveal two autism subtypes, characterized by lower and higher brain connectivity and linked to synaptic and immune-related pathways, respectively.

nature.com

Alessandro Gozzi@gozziale.bsky.social · last yr.

Can we use brain scans to identify biologically distinct "autisms"? And If so, how? In our latest cross-species study 🐭👨 with @iitalk.bsky.social we dive into these questions! Find out more here 👇👇 www.biorxiv.org/content/10.1... Thread below 🧵 1/n

Let us help you with your research! All of our neural dynamics tools, software, protocols, datasets, and even hardware plans are available in one convenient place. Check it out and let us know what you'd like to see next: https://www.allenneuraldynamics.org/tools

“Autism subtypes identified using cross-species functional connectivity analyses” Excellent work by @gozziale.bsky.social and colleagues, now out in @natneuro.nature.com 🧪🧠🧬 www.nature.com/articles/s41...

Autism subtypes identified using cross-species functional connectivity analyses - Nature Neuroscience

Pagani et al. used cross-species fMRI to reveal two autism subtypes, characterized by lower and higher brain connectivity and linked to synaptic and immune-related pathways, respectively.

nature.com

bbrfoundation.org/content/fmri...

fMRI Imaging Revealed 2 Distinct Autism Subtypes Involving Under- and Over-Connectivity Patterns, with Potential Implications for Therapeutic Targeting | Brain & Behavior Research Foundation

Connecting autism’s many human faces with invisible biological factors underlying its diversity of symptoms is a grand challenge facing the research community. As noted by a team of investigators led ...

bbrfoundation.org

Incredibly excited to share the latest published work from the lab: www.science.org/doi/10.1126/.... Using a range of techniques, including closed-loop optogenetics, we show that the ACC modulates pupil linked arousal in real time. Great summary of our findings here: scienceblog.com/your-brain-h...

The anterior cingulate cortex modulates pupil-linked arousal

The anterior cingulate cortex modulates pupil-linked arousal in real time.

science.org

Do brain circuits really sit in a 'soup' of neuromodulators? Are neurons like soggy bits of bread soaked in signaling factors? Is the whole brain just squelching around in one big pool of warm modulators?

Very grateful to all members in the team who contributed to this work over the years. We hope multimodal approaches continue to open new opportunities for understanding how neurochemical dynamics relate to whole-brain fMRI activity. www.nature.com/nprot/volume...