Angus Bucknell

@ahbucknell.com

PhD candidate in the @talbotlabtsl.bsky.social group. Focusing on protein design and effector biology in Magnaporthe oryzae. www.ahbucknell.com

Excited to see our new preprint on bioRxiv! 🌱🤖 We used AI protein design (RFdiffusion + ProteinMPNN) to build brand-new sensor domains from scratch and installed them in a rice NLR immune receptor engineering recognition of a Fusarium effector FoSSP17

@yuxuan-xi.bsky.social · 4w ago

Our new preprint is out! Using AI-guided design (RFdiffusion + ProteinMPNN), we engineered a plant immune receptor to recognise non-cognate pathogen effectors. Huge thanks to our amazing co-authors for making this possible! doi.org/10.64898/202...

Our first invited speaker of the #NRPDTP26 conference is Dr Marco Catoni, from the University of Birmingham. Today he’s talking about combining genomics and plant grafting to investigate mobile RNAs.

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So proud to see this story finally out!🎉 We added new data since our previous preprint—transgenic barley plants with an engineered immune receptor that fights off two fungal pathogens at once. Short 🧵 and link to the original preprint thread on X👇 www.science.org/doi/10.1126/...

Molecular mimicry of a pathogen virulence target by a plant immune receptor

Plants and animals respond to pathogen attack by mounting innate immune responses that require intracellular nucleotide-binding leucine-rich repeat (NLR) proteins. These immune receptors detect pathog...

science.org