Take a look at our new paper on the structure of the EHD2 that, upon oligomerization, forms rings that remodel the plasma membrane and form caveolae. Beautiful work by Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff & Oliver Dumke's team; take a look: www.nature.com/articles/s41...

Dream position for a very recent graduate

Teva Vernoux@tevavernoux.bsky.social · 6d ago

Together with @plantophagy.bsky.social, we have an opened postdoc position for a young scientist that graduated after 01/01/2025, see ad attached

We’re so excited to share our new paper, where we tackle the wealth of structural and functional diversity of anti-phage sensors across bacteria (1/6)

Nature@nature.com · last wk.

Nature research paper: Diverse bacterial pattern recognition receptors sense the core phage proteome go.nature.com/45fpXCZ

Huge congrats to the many authors who over MANY years worked on this (but especially @karaehunt.bsky.social , @trevorbrandt.bsky.social, Karina, @shaharsu.bsky.social and @remenecker.bsky.social. www.nature.com/articles/s41...

Rational design of disordered proteins for sequence–function investigation - Nature

GOOSE enables the design and testing of thousands of disordered protein region sequences to reveal distinct sequence-to-function relationships.

nature.com

Alex Holehouse@alexholehouse.bsky.social · 5mo ago

New (well, very old, but 100% updated) preprint: Rational design of disordered proteins for systematic sequence-to-function investigation Work done in collaboration with @shaharsu.bsky.social lab - check out the three (3) threads from the folks who did the work!

#ResultatScientifique🔎| Pourquoi certains organismes possèdent-ils des génomes bien plus grands que d'autres ? 🌿🧬 ✍️ @gwenaelp.bsky.social 📕 @science.org 👋 @cnrsecologie.bsky.social @cnrs-insu.bsky.social buff.ly/0yTEeB3

Quand la quantité de nutriments détermine la taille et l’architecture des génomes

Le phyto

insb.cnrs.fr

Our laboratory is looking for a PhD student in Functional Genomics (fully funded position). Expected starting date: Oct 2026 More info here: www.igbmc.fr/en/igbmc/lif... Please share 📨

IGBMC@igbmc.bsky.social · 2w ago

PhD position in Functional Genomics, in Raphaël Pantier's lab: Interplay between transcription factors and genome architecture in embryonic stem cells more info : amethis3.unistra.fr/amethis-clie...

I wrote a blog on AI in science and personal convictions: msuskiewicz.github.io/blog/

De novo designed oligomers that respond to copper, small molecules, and phosphorylation... Using a single design strategy? 🧬⚙️ 🎉 Excited to share our new bioRxiv preprint—a collaboration between the Khmelinskaia, Correia, Schoeder and a Tinnefeld labs! www.biorxiv.org/content/10.6...

A generalizable interface-seeded framework for de novo design of functional oligomers

Protein oligomers are ubiquitous in biological systems and essential for function. However, the de novo design of oligomers that controllably assemble in response to exogenous stimuli remains challeng...

biorxiv.org

In memory of Pierre Chambon (1931–2026): a visionary pioneer of modern molecular biology by Hinrich Gronemeyer in @embojournal.org link.springer.com/article/10.1...

In memory of Pierre Chambon (1931–2026): a visionary pioneer of modern molecular biology - The EMBO Journal

The EMBO Journal -

link.springer.com

1/4 Every good defence needs a backup! 🛡️⚔ Out now in @natrevmicro.nature.com our Comment on "𝗶𝗺𝗺𝘂𝗻𝗲 𝘀𝗮𝗳𝗲𝗴𝘂𝗮𝗿𝗱𝗶𝗻𝗴"! 🎉 🔗 www.nature.com/articles/s41...

Immune safeguarding as a conserved principle of antiviral defence - Nature Reviews Microbiology

All organisms defend against viral infections through active immunity mechanisms that clear the virus or population-level mechanisms that cause regulated cell death. Recent research increasingly shows...

nature.com

www.science.org/doi/10.1126/...

Virome-wide ubiquitin ligase discovery reveals diverse mechanisms of immune evasion

Viruses are intracellular parasites that reprogram the host proteome to promote replication and evade immune recognition. We applied a virome-wide library of ~10,000 open reading frames to discover vi...

science.org

Really proud of #Sebastien_Sueron who developed COMPASS to predict Ubiquitinable PROTAC‐Induced Ternary Complexes - chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/... - fruitful collaboration with @xguillory.bsky.social #FrançoisHugues_Porée and #Leif_A_Eriksson... Congratulations to all!

COMPASS: A Computational Pipeline to Identify Linkers Predicting Ubiquitinable PROTAC‐Induced Ternary Complexes

COMPASS enables structure-based screening of PROTAC linker libraries by jointly evaluating ternary complex formation and ubiquitination competence. The pipeline accurately recovers experimentally obs...

chemistry-europe.onlinelibrary.wiley.com

The paperback of CRICK is back from the printers! Out in 6 weeks. £14.99. Has the colour plates and fewer misteaks!

Endogenous molecular glue acts as a signal in human cells - akin to auxin! Metabolite glues as a means of purine sensing and chemotherapeutic response www.nature.com/articles/s41...

Metabolite glues as a means of purine sensing and chemotherapeutic response - Nature

Purines can act as endogenous molecular glues in human cells by anchoring a rate-limiting enzyme in purine biosynthesis to its inhibitor, and modifying this mechanism could provide a way to improve th...

nature.com

The effects of different linkers in fusions of the protein crystallization chaperone 1TEL with target proteins on crystallization were investigated #TELSAM #DARPin #ETV6 doi.org/10.1107/S205...

Our preprint is now out in @natgenet.nature.com ! doi.org/10.1038/s415... We measured Sox2 promoter bursting dynamics with the SCR enhancer positioned at different distances within a genomic locus devoid of confounding effects in mESC: Main findings in the 🧵 below:

Enhancer control of promoter activity and variability via frequency modulation of clustered transcriptional bursts - Nature Genetics

Tünnermann et al. use live-cell imaging to study promoter activity under the control of an enhancer inserted at different genomic distances. RNA production from the promoter occurs in clusters of tran...

doi.org

Luca Giorgetti lab @FMI@lucagiorgetti.bsky.social · last yr.

Celebrating 10 years of our lab with a new preprint: www.biorxiv.org/content/10.1... How does enhancer location within a TAD control transcriptional bursts from a cognate promoter? Experiments by Jana Tünnermann and modelling by Gregory Roth

An encyclopedia of enhancer-gene regulatory interactions — online today! nature.com/articles/s4158… Now with an improved model, expanded maps across 1400+ biosamples, larger validation CRISPR datasets, and guidance on applying the model 1/

Andreas Gschwind@argschwind.bsky.social · 3w ago

Thrilled to share that our ENCODE enhancer–gene mapping paper is now out in Nature! An encyclopedia of human enhancer–gene regulatory interactions: www.nature.com/articles/s41... Thread 👇 1/

🎯 We are so thrilled our new paper @narjournal.bsky.social is out! Fantastic collab with the labs of Gordon Hager NIH & Franck Dequiedt. Heaviest lifting from Greg Fettweiss, Kaustub Wagh, Diana Stavreva & Alba Jiménez-Panizo. Big thanks to Andrea Alegre-Marti JdC 🥳✨️ academic.oup.com/nar/article/...

Looks like a genuine breakthrough for small(ish) particles

Di Jiang@dijiang319.bsky.social · 4w ago

In print today @science.org Laser phase plate improves structure determination of small proteins by cryo-EM | Science www.science.org/doi/10.1126/...

New online: Cytoplasmic lattices store developmentally poised degradative and cytoskeletal complexes in mammalian eggs

Cytoplasmic lattices store developmentally poised degradative and cytoskeletal complexes in mammalian eggs

Nature Structural & Molecular Biology, Published online: 09 July 2026; doi:10.1038/s41594-026-01843-2Li et al. obtain high-resolution, native structures revealing that cytoplasmic lattices in mammalian eggs organize and store degradative and cytoskeletal complexes for early embryonic development.

dlvr.it

Les nouvelles règles envisagées pour l'ANR sont plus qu'inquiétantes. Elles porteraient un immense coup d'arrêt à la recherche fondamentale en France, surchargeraient les jeunes chercheurs, et n'attendraient sans doute même pas leur objectif (apparent) de réduction du nombre de candidatures

Levayer Lab@levayerr.bsky.social · 4w ago

Si les nouvelles règles de l'éligibilité de l'ANR sont bien réelles, alors je ne comprends pas quelle est la logique sous jacente. Au vu de la pyramide des ages, forcer une collaboration avec chercheurs(ses) <10 ans post thèse va de facto exclure 80% des candidats.

Domain swap is a staple in protein engineering. But instead of trial & error, can we predict an ideal crossover w/ comp modeling? Happy to share a wonderful collaboration w/ Jürgen @lassak-lab.bsky.social at my alma mater LMU Munich to convert a protein ligase to an aaRS for β amino acids t.ly/lNpVw

Si les nouvelles règles de l'éligibilité de l'ANR sont bien réelles, alors je ne comprends pas quelle est la logique sous jacente. Au vu de la pyramide des ages, forcer une collaboration avec chercheurs(ses) <10 ans post thèse va de facto exclure 80% des candidats.

Have just seen the news about updated, stricter ANR grant rules in France @agencerecherche.bsky.social . One argument is to better support teams with 'potential towards Europe', meaning European grants. I'm not sure how much sense it makes as a policy. 1/n

RNA can build. A short RNA self-assembles into a 60-subunit icosahedral cage like a viral capsid, but made entirely of RNA. The striking preprint also reveals a 57-nt RNA filament at ~2.7 Å. Congratulations, Lin Huang and colleagues! www.biorxiv.org/content/10.6...

new out in Nature www.nature.com/articles/s41...

Aneuploidy selects for the acquisition of driver genes in breast cancer - Nature

Screening of chromosome arm-level aneuploidies uncovers that these alterations select for specific basal-like breast cancer driver genes, including PLGRKT, an oncogene whose tumour-promoting activity ...

nature.com

We are hiring! Join the fantastic Structural Biology, Biochemistry and Biophysics team at Nature Communications. More information here: springernature.wd3.myworkdayjobs.com/SpringerNatu...

Associate or Senior Editor, Nature Communications (Structural Biology, Biochemistry, or Biophysics)

Job Title: Associate or Senior Editor Locations: Pune, Shanghai, Beijing Application Deadline: 31st July'26 About Springer Nature Springer Nature is one of the leading publishers of research in the wo...

springernature.wd3.myworkdayjobs.com

Our new preprint @biorxivpreprint.bsky.social, led by @katsuminami.bsky.social‬ et al.! 🎉 www.biorxiv.org/content/10.6... Machine learning-assisted Repli-Histo labeling and single-nucleosome imaging reveal distinct transcription-dependent chromatin constraints across euchromatin and heterochromatin.

Okay the lab is now really living preprints to accelerate Science. It takes so long to publish a story in journals. So the only option to talk openly about our work are preprints. We currently have 6 preprints - check them out! More coming, one currently uploading and another one ready soon.

Effects of residue substitutions on the cellular abundance of proteins

Effects of residue substitutions on the cellular abundance of proteins

Empirical substitution matrices from experimental measurements on 31,614 variants accurately predict cellular protein abundance changes using only amino-acid substitution and whether the site is buried...

buff.ly